Renal oncocytoma biopsy

Renal oncocytoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

On biopsy, renal oncocytoma is characterized by oncocytes and large eosinophilic cells.

Biopsy

• On biopsy, renal oncocytoma is characterized by oncocytes and large eosinophilic cells.
• Biopsy is insufficient to distinguish renal oncocytoma from renal cell carcinoma, therefore immunostaining may be required.
• Immunohistochemical profile

• Cytokeratin AE1/AE3 +
• Vimentin -
• Epithelial membrane antigen +
• CD10+/-
• CK7 +/- parcellaire
• CK20 -
• CK19 -
• AMACR (Racemase) -
• S100 +
• CD117 +
• Cadherin-E +
• TFE3 -
• CAM5.2 +