Renal oncocytoma natural history, complications and prognosis: Difference between revisions

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Latest revision as of 23:57, 29 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2] Shanshan Cen, M.D. [3]

Overview

The median age at the time of surgery is 62 to 68 years. In 10% to 32% of patients with renal oncocytoma, coexcitente RCC are seen. Prognosis is generally excellent, There are only two cases of metastatic renal oncocytoma were reported. Since the definite diagnosis is maintain just after surgery, most of patients are undergone operation.

Natural History, Complications, and Prognosis

Natural History

The median age at the time of surgery is 62 to 68 years. ^[1]
In 10% to 32% of patients with renal oncocytoma, coexcitente RCC are seen.^[2]^[3]

Prognosis

Prognosis is generally excellent, There are only two cases of metastatic renal oncocytoma were reported.^[4]^[5]
Since the definite diagnosis is maintain just after surgery, most of patients are undergone operation.^[6]^[1]^[7]

References

↑ ^1.0 ^1.1 Neuzillet, Yann; Lechevallier, Eric; Andre, March; Daniel, Laurent; Nahon, Olivier; Coulange, Christian (2005). "Follow-up of renal oncocytoma diagnosed by percutaneous tumor biopsy". Urology. 66 (6): 1181–1185. doi:10.1016/j.urology.2005.06.001. ISSN 0090-4295.
↑ M. R. Licht, A. C. Novick, R. R. Tubbs, E. A. Klein, H. S. Levin & S. B. Streem (1993). "Renal oncocytoma: clinical and biological correlates". The Journal of urology. 150 (5 Pt 1): 1380–1383. PMID 8411404. Unknown parameter |month= ignored (help)
↑ Dechet, Christopher B.; Bostwick, David G.; Blute, Michael L.; Bryant, Sandra C.; Zincke, Horst (1999). "RENAL ONCOCYTOMA: MULTIFOCALITY, BILATERALISM, METACHRONOUS TUMOR DEVELOPMENT AND COEXISTENT RENAL CELL CARCINOMA". Journal of Urology. 162 (1): 40–42. doi:10.1097/00005392-199907000-00010. ISSN 0022-5347.
↑ Lieber MM (1990). "Renal oncocytoma: prognosis and treatment". European Urology. 18 Suppl 2: 17–21. PMID 2226597.
↑ B. Perez-Ordonez, G. Hamed, S. Campbell, R. A. Erlandson, P. Russo, P. B. Gaudin & V. E. Reuter (1997). "Renal oncocytoma: a clinicopathologic study of 70 cases". The American journal of surgical pathology. 21 (8): 871–883. PMID 9255250. Unknown parameter |month= ignored (help)
↑ Leo Romis, Luca Cindolo, Jean Jacques Patard, Giovanni Messina, Vincenzo Altieri, Laurent Salomon, Claude Clement Abbou, Dominique Chopin, Bernard Lobel & Alexandre de La Taille (2004). "Frequency, clinical presentation and evolution of renal oncocytomas: multicentric experience from a European database". European urology. 45 (1): 53–57. PMID 14667516. Unknown parameter |month= ignored (help)
↑ D. B. Spring, R. C. Ulirsch, W. R. Starke & S. Jr Brown (1985). "Renal oncocytoma followed for eighteen years without resection". Urology. 26 (4): 389–392. PMID 3901483. Unknown parameter |month= ignored (help)

Template:WH Template:WS

[NeuzilletLechevallier2005-1] 1.0 ^1.1 Neuzillet, Yann; Lechevallier, Eric; Andre, March; Daniel, Laurent; Nahon, Olivier; Coulange, Christian (2005). "Follow-up of renal oncocytoma diagnosed by percutaneous tumor biopsy". Urology. 66 (6): 1181–1185. doi:10.1016/j.urology.2005.06.001. ISSN 0090-4295.

[2] M. R. Licht, A. C. Novick, R. R. Tubbs, E. A. Klein, H. S. Levin & S. B. Streem (1993). "Renal oncocytoma: clinical and biological correlates". The Journal of urology. 150 (5 Pt 1): 1380–1383. PMID 8411404. Unknown parameter |month= ignored (help)

[DechetBostwick1999-3] Dechet, Christopher B.; Bostwick, David G.; Blute, Michael L.; Bryant, Sandra C.; Zincke, Horst (1999). "RENAL ONCOCYTOMA: MULTIFOCALITY, BILATERALISM, METACHRONOUS TUMOR DEVELOPMENT AND COEXISTENT RENAL CELL CARCINOMA". Journal of Urology. 162 (1): 40–42. doi:10.1097/00005392-199907000-00010. ISSN 0022-5347.

[pmid2226597-4] Lieber MM (1990). "Renal oncocytoma: prognosis and treatment". European Urology. 18 Suppl 2: 17–21. PMID 2226597.

[5] B. Perez-Ordonez, G. Hamed, S. Campbell, R. A. Erlandson, P. Russo, P. B. Gaudin & V. E. Reuter (1997). "Renal oncocytoma: a clinicopathologic study of 70 cases". The American journal of surgical pathology. 21 (8): 871–883. PMID 9255250. Unknown parameter |month= ignored (help)

[6] Leo Romis, Luca Cindolo, Jean Jacques Patard, Giovanni Messina, Vincenzo Altieri, Laurent Salomon, Claude Clement Abbou, Dominique Chopin, Bernard Lobel & Alexandre de La Taille (2004). "Frequency, clinical presentation and evolution of renal oncocytomas: multicentric experience from a European database". European urology. 45 (1): 53–57. PMID 14667516. Unknown parameter |month= ignored (help)

[7] D. B. Spring, R. C. Ulirsch, W. R. Starke & S. Jr Brown (1985). "Renal oncocytoma followed for eighteen years without resection". Urology. 26 (4): 389–392. PMID 3901483. Unknown parameter |month= ignored (help)

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[2]

[3]

[4]

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[6]

[7]

@@ Line 3: / Line 3: @@
 {{CMG}}; {{AE}}{{Homa}} {{SC}}
 ==Overview==
-[[Prognosis]] of renal oncocytoma is generally excellent.<ref name="pmid2226597">{{cite journal |vauthors=Lieber MM |title=Renal oncocytoma: prognosis and treatment |journal=[[European Urology]] |volume=18 Suppl 2 |issue= |pages=17–21 |year=1990 |pmid=2226597 |doi= |url=}}</ref>
+The median age at the time of [[surgery]] is 62 to 68 years. In 10% to 32% of [[patients]] with renal oncocytoma, coexcitente [[RCC]] are seen. [[Prognosis]] is generally excellent, There are only two cases of [[metastatic]] renal oncocytoma were reported. Since the definite [[diagnosis]] is maintain just after [[surgery]], most of [[patients]] are undergone operation.
-==Prognosis==
-Prognosis of renal oncocytoma is generally excellent.<ref name="pmid2226597">{{cite journal |vauthors=Lieber MM |title=Renal oncocytoma: prognosis and treatment |journal=[[European Urology]] |volume=18 Suppl 2 |issue= |pages=17–21 |year=1990 |pmid=2226597 |doi= |url=}}</ref>
-==Overview==
-If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
-OR
-Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
-OR
-Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
 ==Natural History, Complications, and Prognosis==
 ===Natural History===
-*The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
+*The median age at the time of [[surgery]] is 62 to 68 years. <ref name="NeuzilletLechevallier2005">{{cite journal|last1=Neuzillet|first1=Yann|last2=Lechevallier|first2=Eric|last3=Andre|first3=March|last4=Daniel|first4=Laurent|last5=Nahon|first5=Olivier|last6=Coulange|first6=Christian|title=Follow-up of renal oncocytoma diagnosed by percutaneous tumor biopsy|journal=Urology|volume=66|issue=6|year=2005|pages=1181–1185|issn=00904295|doi=10.1016/j.urology.2005.06.001}}</ref>
-*The symptoms of (disease name) typically develop ___ years after exposure to ___.
+*In 10% to 32% of [[patients]] with renal oncocytoma, coexcitente [[RCC]] are seen.<ref>{{Cite journal
-*If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
+ | author = [[M. R. Licht]], [[A. C. Novick]], [[R. R. Tubbs]], [[E. A. Klein]], [[H. S. Levin]] & [[S. B. Streem]]
+ | title = Renal oncocytoma: clinical and biological correlates
-===Complications===
+ | journal = [[The Journal of urology]]
-*Common complications of [disease name] include:
+ | volume = 150
-**[Complication 1]
+ | issue = 5 Pt 1
-**[Complication 2]
+ | pages = 1380–1383
-**[Complication 3]
+ | year = 1993
+ | month = November
+ | pmid = 8411404
+}}</ref><ref name="DechetBostwick1999">{{cite journal|last1=Dechet|first1=Christopher B.|last2=Bostwick|first2=David G.|last3=Blute|first3=Michael L.|last4=Bryant|first4=Sandra C.|last5=Zincke|first5=Horst|title=RENAL ONCOCYTOMA: MULTIFOCALITY, BILATERALISM, METACHRONOUS TUMOR DEVELOPMENT AND COEXISTENT RENAL CELL CARCINOMA|journal=Journal of Urology|volume=162|issue=1|year=1999|pages=40–42|issn=0022-5347|doi=10.1097/00005392-199907000-00010}}</ref>
 ===Prognosis===
-*Prognosis is generally good, There are only two cases of metastatic  renal .
+*[[Prognosis]] is generally excellent, There are only two cases of [[metastatic]] renal oncocytoma were reported.<ref name="pmid2226597">{{cite journal |vauthors=Lieber MM |title=Renal oncocytoma: prognosis and treatment |journal=[[European Urology]] |volume=18 Suppl 2 |issue= |pages=17–21 |year=1990 |pmid=2226597 |doi= |url=}}</ref><ref>{{Cite journal
-*Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
+ | author = [[B. Perez-Ordonez]], [[G. Hamed]], [[S. Campbell]], [[R. A. Erlandson]], [[P. Russo]], [[P. B. Gaudin]] & [[V. E. Reuter]]
-*The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
+ | title = Renal oncocytoma: a clinicopathologic study of 70 cases
-*[Subtype of disease/malignancy] is associated with the most favorable prognosis.
+ | journal = [[The American journal of surgical pathology]]
-*The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
+ | volume = 21
+ | issue = 8
-Renal oncocytoma is regarded as a benign neoplasia. Although some malignant oncocytomas with local organ invasion and metastases have been described in early reports,20,8,105,4 those cases examined could be confused with eosinophilic variants of chromophobe RCC, because Hale’s colloidal iron stain and electron microscopy were not applied.106 However, despite the strict histological criteria, two oncocytomas that caused liver metastasis confirmed by needle biopsy or metastatic (liver and bone) death have been reported.6 Unfortunately, no genetic material from such cases was available for analysis to confirm the original histological diagnosis.
+ | pages = 871–883
+ | year = 1997
-Today, the vast majority of oncocytomas are operated upon. There are several reasons for this policy. First, definitive preoperative diagnosis is not, at present, possible. As such, the differential diagnosis of RCC cannot be excluded. Furthermore, as was discussed previously, oncocytoma and RCC may exist concomitantly. Second, the natural evolution of renal oncocytomas is not known. There are not many articles in the English literature that address the issue of nonoperative management of oncocytomas [70,78,79]. Romis et al. made a retrospective review of patients with oncocytoma and their management. One patient out of 32 with oncocytoma was not operated because he had a previous contralateral nephrectomy for nephrolithiasis. This patient was diagnosed with percutaneous biopsy of the renal tumor. In order to avoid hemodialysis, he was followed with ultrasound (US) and CT scans for 30 months. The tumor was 6 cm in diameter and stable throughout the follow-up period [70]. Neuzillet et al. retrospectively analyzed 15 cases of asymptomatic oncocytomas in their institute, diagnosed by percutaneous core biopsy. The authors decided to monitor the patients with Doppler ultrasound or CT scans for the first 6 month after the diagnosis, and biannually thereafter. Mean follow-up time was 40.1 months. Four patients were operated upon during the follow-up period because of fast tumor growth (mean growth rate 2.4 cm/y).
+ | month = August
+ | pmid = 9255250
-The average delay time for the operation was 16.5 months. Final pathologic report confirmed oncocytoma in all 4 cases. Nine patients (60%) were only followed. In this group of patients the mean growth rate of the tumor was 0.7 cm/y. The authors concluded that high initial tumor volume (greater than 5 cm) or fast-growing oncocytoma (greater than 0.5 cm/y) are indications for surgery [78]. Spring et al. reported on a patient with oncocytoma who was wrongly diagnosed with renal cyst and followed for 18 years. The patient was followed with US during this period. During the follow-up period, the renal mass did not change in appearance or size. Finally, a CT scan was performed and a solid mass was demonstrated. The mass was resected and the diagnosis of renal oncocytoma was made. During the operation, vascular and perinephric fat infiltration were noted [79].
+}}</ref>
+*Since the definite [[diagnosis]] is maintain just after [[surgery]], most of [[patients]] are undergone operation.<ref>{{Cite journal
-Typical renal oncocytomas, as defined by modern pathologic criteria, almost invariably appear to have benign clinical behavior [7,25]. In the most recent review of the Mayo Clinic database no patient with oncocytoma developed metastases (mean follow-up, 41 months). Another recent large series documented two patients (out of 70) with apparent metastases, one of whom had liver and bone involvement and died of disease (not biopsy-confirmed as oncocytoma), and another with a solitary biopsy-proven liver metastasis who was followed expectantly and did not progress [4]. Older reports of “metastatic oncocytoma” could certainly represent chromophobe RCCs incorrectly diagnosed as oncocytoma, or metastases from synchronous or metachronous RCCs
+ | author = [[Leo Romis]], [[Luca Cindolo]], [[Jean Jacques Patard]], [[Giovanni Messina]], [[Vincenzo Altieri]], [[Laurent Salomon]], [[Claude Clement Abbou]], [[Dominique Chopin]], [[Bernard Lobel]] & [[Alexandre de La Taille]]
+ | title = Frequency, clinical presentation and evolution of renal oncocytomas: multicentric experience from a European database
+ | journal = [[European urology]]
+ | volume = 45
+ | issue = 1
+ | pages = 53–57
+ | year = 2004
+ | month = January
+ | pmid = 14667516
+}}</ref><ref name="NeuzilletLechevallier2005">{{cite journal|last1=Neuzillet|first1=Yann|last2=Lechevallier|first2=Eric|last3=Andre|first3=March|last4=Daniel|first4=Laurent|last5=Nahon|first5=Olivier|last6=Coulange|first6=Christian|title=Follow-up of renal oncocytoma diagnosed by percutaneous tumor biopsy|journal=Urology|volume=66|issue=6|year=2005|pages=1181–1185|issn=00904295|doi=10.1016/j.urology.2005.06.001}}</ref><ref>{{Cite journal
+ | author = [[D. B. Spring]], [[R. C. Ulirsch]], [[W. R. Starke]] & [[S. Jr Brown]]
+ | title = Renal oncocytoma followed for eighteen years without resection
+ | journal = [[Urology]]
+ | volume = 26
+ | issue = 4
+ | pages = 389–392
+ | year = 1985
+ | month = October
+ | pmid = 3901483
+}}</ref>
 ==References==
 {{reflist|2}}
@@ Line 57: / Line 64: @@
 [[Category:Oncology]]
 [[Category:Nephrology]]
-[[Category: Primary care]]