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==Classification==
==Classification==
*Restless leg syndrome (RLS), may be classified into two groups:
Restless leg syndrome (RLS), may be classified into two groups:<ref name="pmid18360657">{{cite journal| author=Cotter PE, O'Keeffe ST| title=Restless leg syndrome: is it a real problem? | journal=Ther Clin Risk Manag | year= 2006 | volume= 2 | issue= 4 | pages= 465-75 | pmid=18360657 | doi= | pmc=1936366 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18360657  }} </ref>
**Primary and secondary:
*Primary and secondary:
*** Primary RLS is [[idiopathic]] and the cause of that is unknown which is familial in up to two thirds of patients. Primary RLS usually begins before approximately 40 to 45 years of age, and can even occur as early as the first year of life.  In primary RLS, the onset is often slow.
** Primary RLS is [[idiopathic]] and the cause of that is unknown which is familial in up to two thirds of patients. Primary RLS usually begins before approximately 40 to 45 years of age, and can even occur as early as the first year of life.  In primary RLS, the onset is often slow.<ref name="pmid23748511">{{cite journal| author=Bogan RK, Cheray JA| title=Restless legs syndrome: a review of diagnosis and management in primary care. | journal=Postgrad Med | year= 2013 | volume= 125 | issue= 3 | pages= 99-111 | pmid=23748511 | doi=10.3810/pgm.2013.05.2636 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23748511  }} </ref>
***Secondary
**Secondary RLS may also be secondary to a number of conditions including:<ref name="pmid23211049">{{cite journal| author=Peeraully T, Tan EK| title=Linking restless legs syndrome with Parkinson's disease: clinical, imaging and genetic evidence. | journal=Transl Neurodegener | year= 2012 | volume= 1 | issue= 1 | pages= 6 | pmid=23211049 | doi=10.1186/2047-9158-1-6 | pmc=3514082 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23211049  }} </ref><ref name="pmid17566122">{{cite journal| author=Allen RP, Earley CJ| title=The role of iron in restless legs syndrome. | journal=Mov Disord | year= 2007 | volume= 22 Suppl 18 | issue=  | pages= S440-8 | pmid=17566122 | doi=10.1002/mds.21607 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17566122  }} </ref><ref name="pmid24768121">{{cite journal| author=Srivanitchapoom P, Pandey S, Hallett M| title=Restless legs syndrome and pregnancy: a review. | journal=Parkinsonism Relat Disord | year= 2014 | volume= 20 | issue= 7 | pages= 716-22 | pmid=24768121 | doi=10.1016/j.parkreldis.2014.03.027 | pmc=4058350 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24768121  }} </ref><ref name="pmid25674109">{{cite journal| author=Haider I, Anees M, Shahid SA| title=Restless legs syndrome in end stage renal disease patients on haemodialysis. | journal=Pak J Med Sci | year= 2014 | volume= 30 | issue= 6 | pages= 1209-12 | pmid=25674109 | doi=10.12669/pjms.306.5691 | pmc=4320701 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25674109  }} </ref><ref name="pmid895774">{{cite journal| author=Botez MI, Lambert B| title=Folate deficiency and restless-legs syndrome in pregnancy. | journal=N Engl J Med | year= 1977 | volume= 297 | issue= 12 | pages= 670 | pmid=895774 | doi=10.1056/NEJM197709222971220 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=895774  }} </ref><ref name="pmid3081215">{{cite journal| author=Reynolds G, Blake DR, Pall HS, Williams A| title=Restless leg syndrome and rheumatoid arthritis. | journal=Br Med J (Clin Res Ed) | year= 1986 | volume= 292 | issue= 6521 | pages= 659-60 | pmid=3081215 | doi= | pmc=1339645 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3081215 }} </ref>
 
***[[Iron deficiency anemia|Iron deficiency]]
OR
***[[Pregnancy]]
*[Disease name] may be classified into [large number > 6] subtypes based on:  
***[[End-stage renal failure]]
**[Classification method 1]
***[[varicose vein]]
**[Classification method 2]
***Venous reflux
**[Classification method 3]
***[[folate deficiency]]
*[Disease name] may be classified into several subtypes based on:
***[[sleep apnea]]
**[Classification method 1]
***[[uremia]]
**[Classification method 2]
***[[diabetes mellitus|Diabetes]]
**[Classification method 3]
***Thyroid problems
OR
***Peripheral neuropathy
*Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.
***[[Parkinson's disease]]
OR
***Certain [[auto-immune disorders]] such as:
*If the staging system involves specific and characteristic findings and features:
****[[Sjögren's syndrome]],  
*According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
****[[Celiac Disease]]
OR
****[[rheumatoid arthritis]]
*The staging of [malignancy name] is based on the [staging system].
**Secondary RLS is most common in those presenting for the first time in later life.<ref name="pmid18360657">{{cite journal| author=Cotter PE, O'Keeffe ST| title=Restless leg syndrome: is it a real problem? | journal=Ther Clin Risk Manag | year= 2006 | volume= 2 | issue= 4 | pages= 465-75 | pmid=18360657 | doi= | pmc=1936366 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18360657  }} </ref>
OR
*There is no established system for the staging of [malignancy name].
==Classification==
RLS is either primary or secondary.
*
 
===Secondary===
* Secondary RLS often has a sudden onset and may be daily from the very beginning. It often occurs after the age of 40, however it can occur earlier.  It is most associated with specific medical conditions or the use of certain drugs. The most commonly associated medical condition is [[iron deficiency (medicine)|iron deficiency]], which accounts for just over 20% of all cases of RLS.  The conditions include: pregnancy, [[varicose vein]] or venous reflux, [[folate deficiency]], [[sleep apnea]], [[uremia]], [[diabetes mellitus|diabetes]], thyroid problems, peripheral neuropathy, [[Parkinson's disease]] and certain auto-immune disorders such as [[Sjögren's syndrome]], [[Celiac Disease]], and [[rheumatoid arthritis]]. Treatment of the underlying condition, or cessation of use of the offending drug, often eliminates the RLS.
 
==References==
==References==
{{reflist|2}}
{{reflist|2}}
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[[Category:Sleep disorders]]
[[Category:Sleep disorders]]
[[Category:Syndromes]]
[[Category:Syndromes]]
[[Category:Neurology]]
[[Category:Neurology]]
[[Category:Primary care]]
[[Category:Needs overview]]
[[Category:Needs overview]]
{{WH}}
{{WS}}

Latest revision as of 23:58, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

Classification

Restless leg syndrome (RLS), may be classified into two groups:[1]

References

  1. ↑ 1.0 1.1 Cotter PE, O'Keeffe ST (2006). "Restless leg syndrome: is it a real problem?". Ther Clin Risk Manag. 2 (4): 465–75. PMC 1936366. PMID 18360657.
  2. ↑ Bogan RK, Cheray JA (2013). "Restless legs syndrome: a review of diagnosis and management in primary care". Postgrad Med. 125 (3): 99–111. doi:10.3810/pgm.2013.05.2636. PMID 23748511.
  3. ↑ Peeraully T, Tan EK (2012). "Linking restless legs syndrome with Parkinson's disease: clinical, imaging and genetic evidence". Transl Neurodegener. 1 (1): 6. doi:10.1186/2047-9158-1-6. PMC 3514082. PMID 23211049.
  4. ↑ Allen RP, Earley CJ (2007). "The role of iron in restless legs syndrome". Mov Disord. 22 Suppl 18: S440–8. doi:10.1002/mds.21607. PMID 17566122.
  5. ↑ Srivanitchapoom P, Pandey S, Hallett M (2014). "Restless legs syndrome and pregnancy: a review". Parkinsonism Relat Disord. 20 (7): 716–22. doi:10.1016/j.parkreldis.2014.03.027. PMC 4058350. PMID 24768121.
  6. ↑ Haider I, Anees M, Shahid SA (2014). "Restless legs syndrome in end stage renal disease patients on haemodialysis". Pak J Med Sci. 30 (6): 1209–12. doi:10.12669/pjms.306.5691. PMC 4320701. PMID 25674109.
  7. ↑ Botez MI, Lambert B (1977). "Folate deficiency and restless-legs syndrome in pregnancy". N Engl J Med. 297 (12): 670. doi:10.1056/NEJM197709222971220. PMID 895774.
  8. ↑ Reynolds G, Blake DR, Pall HS, Williams A (1986). "Restless leg syndrome and rheumatoid arthritis". Br Med J (Clin Res Ed). 292 (6521): 659–60. PMC 1339645. PMID 3081215.

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