Riedel's thyroiditis medical therapy: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Riedel's thyroiditis}} | {{Riedel's thyroiditis}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{MMF}} | ||
==Overview== | ==Overview== | ||
Pharmacologic medical therapies for Riedel's thyroiditis include [[corticosteroids]], [[tamoxifen]], and [[Mycophenolate sodium|mycophenolate mofetil]]. | |||
==Medical Therapy== | ==Medical Therapy== | ||
*Pharmacologic medical therapies for Riedel's thyroiditis include | *Pharmacologic medical therapies for Riedel's thyroiditis include [[corticosteroids]] and [[tamoxifen]].<ref name="pmid8120524">{{cite journal |vauthors=Zimmermann-Belsing T, Feldt-Rasmussen U |title=Riedel's thyroiditis: an autoimmune or primary fibrotic disease? |journal=J. Intern. Med. |volume=235 |issue=3 |pages=271–4 |year=1994 |pmid=8120524 |doi= |url=}}</ref><ref name="pmid9497955">{{cite journal |vauthors=Vaidya B, Harris PE, Barrett P, Kendall-Taylor P |title=Corticosteroid therapy in Riedel's thyroiditis |journal=Postgrad Med J |volume=73 |issue=866 |pages=817–9 |year=1997 |pmid=9497955 |pmc=2431527 |doi= |url=}}</ref><ref name="pmid263470">{{cite journal |vauthors=Chopra D, Wool MS, Crosson A, Sawin CT |title=Riedel's struma associated with subacute thyroiditis, hypothyroidism, and hypoparathyroidism |journal=J. Clin. Endocrinol. Metab. |volume=46 |issue=6 |pages=869–71 |year=1978 |pmid=263470 |doi=10.1210/jcem-46-6-869 |url=}}</ref><ref name="pmid7560814">{{cite journal |vauthors=Bagnasco M, Passalacqua G, Pronzato C, Albano M, Torre G, Scordamaglia A |title=Fibrous invasive (Riedel's) thyroiditis with critical response to steroid treatment |journal=J. Endocrinol. Invest. |volume=18 |issue=4 |pages=305–7 |year=1995 |pmid=7560814 |doi=10.1007/BF03347818 |url=}}</ref><ref name="pmid5694137">{{cite journal |vauthors=Thomson JA, Jackson IM, Duguid WP |title=The effect of steroid therapy on Riedel's thyroiditis |journal=Scott Med J |volume=13 |issue=1 |pages=13–6 |year=1968 |pmid=5694137 |doi=10.1177/003693306801300103 |url=}}</ref><ref name="pmid12698518">{{cite journal |author=Dabelic N, Jukic T, Labar Z, Novosel SA, Matesa N, Kusic Z |title=Riedel's thyroiditis treated with tamoxifen |journal=Croat. Med. J. |volume=44 |issue=2 |pages=239–41 |year=2003|pmid=12698518 |doi= |url=http://www.cmj.hr/2003/44/2/12698518.pdf|format=PDF}}</ref> | ||
*[[Mycophenolate sodium|Mycophenolate mofetil]] is also used in combination with [[corticosteroids]].<ref name="pmid20067381">{{cite journal |vauthors=Levy JM, Hasney CP, Friedlander PL, Kandil E, Occhipinti EA, Kahn MJ |title=Combined mycophenolate mofetil and prednisone therapy in tamoxifen- and prednisone-resistant Reidel's thyroiditis |journal=Thyroid |volume=20 |issue=1 |pages=105–7 |year=2010 |pmid=20067381 |doi=10.1089/thy.2009.0324 |url=}}</ref><ref name="pmid21568724">{{cite journal |vauthors=Fatourechi MM, Hay ID, McIver B, Sebo TJ, Fatourechi V |title=Invasive fibrous thyroiditis (Riedel thyroiditis): the Mayo Clinic experience, 1976-2008 |journal=Thyroid |volume=21 |issue=7 |pages=765–72 |year=2011 |pmid=21568724 |doi=10.1089/thy.2010.0453 |url=}}</ref> | |||
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===Treatment regimens for Riedel's thyroiditis=== | |||
The effectiveness of therapy and dosages for Riedel's thyroiditis have not yet been assessed completely. As a result, the exact dosage regimens and duration of therapy cannot be defined. The current recommendations are based on the clinical manifestations, associated conditions, and the response to treatment. | |||
* Preferred regimen (1): [[Prednisone]] 15-60mg PO q24h for 6 months to 2 years | |||
* Preferred regimen (2): [[Prednisone]] 500 mg PO q24h for 6 months to 2 years | |||
* Alternative regimen (1): [[Tamoxifen]] 10-20 mg PO q24h for 6 months to 2 years | |||
* Alternative regimen (1): [[Mycophenolate sodium|Mycophenolate mofetil]] 1 g PO q12h for 6 months to 2 years | |||
==References== | ==References== | ||
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[[Category:Medicine]] | |||
[[Category:Endocrinology]] | |||
[[Category:Up-To-Date]] | |||
Latest revision as of 00:01, 30 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
Pharmacologic medical therapies for Riedel's thyroiditis include corticosteroids, tamoxifen, and mycophenolate mofetil.
Medical Therapy
- Pharmacologic medical therapies for Riedel's thyroiditis include corticosteroids and tamoxifen.[1][2][3][4][5][6]
- Mycophenolate mofetil is also used in combination with corticosteroids.[7][8]
Treatment regimens for Riedel's thyroiditis
The effectiveness of therapy and dosages for Riedel's thyroiditis have not yet been assessed completely. As a result, the exact dosage regimens and duration of therapy cannot be defined. The current recommendations are based on the clinical manifestations, associated conditions, and the response to treatment.
- Preferred regimen (1): Prednisone 15-60mg PO q24h for 6 months to 2 years
- Preferred regimen (2): Prednisone 500 mg PO q24h for 6 months to 2 years
- Alternative regimen (1): Tamoxifen 10-20 mg PO q24h for 6 months to 2 years
- Alternative regimen (1): Mycophenolate mofetil 1 g PO q12h for 6 months to 2 years
References
- ↑ Zimmermann-Belsing T, Feldt-Rasmussen U (1994). "Riedel's thyroiditis: an autoimmune or primary fibrotic disease?". J. Intern. Med. 235 (3): 271–4. PMID 8120524.
- ↑ Vaidya B, Harris PE, Barrett P, Kendall-Taylor P (1997). "Corticosteroid therapy in Riedel's thyroiditis". Postgrad Med J. 73 (866): 817–9. PMC 2431527. PMID 9497955.
- ↑ Chopra D, Wool MS, Crosson A, Sawin CT (1978). "Riedel's struma associated with subacute thyroiditis, hypothyroidism, and hypoparathyroidism". J. Clin. Endocrinol. Metab. 46 (6): 869–71. doi:10.1210/jcem-46-6-869. PMID 263470.
- ↑ Bagnasco M, Passalacqua G, Pronzato C, Albano M, Torre G, Scordamaglia A (1995). "Fibrous invasive (Riedel's) thyroiditis with critical response to steroid treatment". J. Endocrinol. Invest. 18 (4): 305–7. doi:10.1007/BF03347818. PMID 7560814.
- ↑ Thomson JA, Jackson IM, Duguid WP (1968). "The effect of steroid therapy on Riedel's thyroiditis". Scott Med J. 13 (1): 13–6. doi:10.1177/003693306801300103. PMID 5694137.
- ↑ Dabelic N, Jukic T, Labar Z, Novosel SA, Matesa N, Kusic Z (2003). "Riedel's thyroiditis treated with tamoxifen" (PDF). Croat. Med. J. 44 (2): 239–41. PMID 12698518.
- ↑ Levy JM, Hasney CP, Friedlander PL, Kandil E, Occhipinti EA, Kahn MJ (2010). "Combined mycophenolate mofetil and prednisone therapy in tamoxifen- and prednisone-resistant Reidel's thyroiditis". Thyroid. 20 (1): 105–7. doi:10.1089/thy.2009.0324. PMID 20067381.
- ↑ Fatourechi MM, Hay ID, McIver B, Sebo TJ, Fatourechi V (2011). "Invasive fibrous thyroiditis (Riedel thyroiditis): the Mayo Clinic experience, 1976-2008". Thyroid. 21 (7): 765–72. doi:10.1089/thy.2010.0453. PMID 21568724.