Roseola laboratory findings: Difference between revisions
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{{Roseola}} | {{Roseola}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}}{{DAMI}} | ||
==Overview== | ==Overview== | ||
The diagnosis of roseola is made clinically. However, in atypical cases, the diagnosis can be made by both serologic and direct detection of [[Human herpes virus 6|HHV6]] virus in the saliva of the patient. Expected results of diagnostic studies include antigen detection, [[PCR]], and [[immunofluorescence]]. | |||
==Laboratory findings== | ==Laboratory findings== | ||
*The diagnosis of HHV-6A, HHV-6B, and HHV-7 infections is based on gene amplification (PCR). It allows for the detection and quantification of the viral genome, than on serology, which is mainly indicated in case of primary infection. | *The diagnosis of HHV-6A, [[Human herpesvirus 6|HHV-6B]], and [[HHV-7]] infections is based on [[gene amplification]] ([[PCR]]). It allows for the detection and quantification of the [[viral]] genome, than on serology, which is mainly indicated in case of primary infection.<ref name="pmid27773488">{{cite journal| author=Agut H, Bonnafous P, Gautheret-Dejean A| title=Update on infections with human herpesviruses 6A, 6B, and 7. | journal=Med Mal Infect | year= 2017 | volume= 47 | issue= 2 | pages= 83-91 | pmid=27773488 | doi=10.1016/j.medmal.2016.09.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27773488 }} </ref> | ||
*[[Neutropenia]] | |||
*Relative atypical [[lymphocytosis]]<ref name="pmid13958107">{{cite journal| author=JURETIC M| title=Exanthema subitum a review of 243 cases. | journal=Helv Paediatr Acta | year= 1963 | volume= 18 | issue= | pages= 80-95 | pmid=13958107 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13958107 }} </ref> | |||
*[[Thrombocytopenia]] caused by bone marrow suppression.<ref name="pmid11990308">{{cite journal| author=Hashimoto H, Maruyama H, Fujimoto K, Sakakura T, Seishu S, Okuda N| title=Hematologic findings associated with thrombocytopenia during the acute phase of exanthem subitum confirmed by primary human herpesvirus-6 infection. | journal=J Pediatr Hematol Oncol | year= 2002 | volume= 24 | issue= 3 | pages= 211-4 | pmid=11990308 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11990308 }} </ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Emergency mdicine]] | |||
[[Category:Disease]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Infectious disease]] | |||
[[Category:Neurology]] | |||
[[Category:Pediatrics]] | |||
[[Category:Dermatology]] | |||
Latest revision as of 00:03, 30 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]
Overview
The diagnosis of roseola is made clinically. However, in atypical cases, the diagnosis can be made by both serologic and direct detection of HHV6 virus in the saliva of the patient. Expected results of diagnostic studies include antigen detection, PCR, and immunofluorescence.
Laboratory findings
- The diagnosis of HHV-6A, HHV-6B, and HHV-7 infections is based on gene amplification (PCR). It allows for the detection and quantification of the viral genome, than on serology, which is mainly indicated in case of primary infection.[1]
- Neutropenia
- Relative atypical lymphocytosis[2]
- Thrombocytopenia caused by bone marrow suppression.[3]
References
- ↑ Agut H, Bonnafous P, Gautheret-Dejean A (2017). "Update on infections with human herpesviruses 6A, 6B, and 7". Med Mal Infect. 47 (2): 83–91. doi:10.1016/j.medmal.2016.09.004. PMID 27773488.
- ↑ JURETIC M (1963). "Exanthema subitum a review of 243 cases". Helv Paediatr Acta. 18: 80–95. PMID 13958107.
- ↑ Hashimoto H, Maruyama H, Fujimoto K, Sakakura T, Seishu S, Okuda N (2002). "Hematologic findings associated with thrombocytopenia during the acute phase of exanthem subitum confirmed by primary human herpesvirus-6 infection". J Pediatr Hematol Oncol. 24 (3): 211–4. PMID 11990308.