Sjögren's syndrome laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Sjögren's syndrome}} | {{Sjögren's syndrome}} | ||
{{CMG}} | {{CMG}} {{AE}} {{F.K}} | ||
==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of Sjögren's syndrome include elevated [[erythrocyte sedimentation rate]] ([[Erythrocyte sedimentation rate|ESR]]), [[cytopenia]], and presence of anti-SSA/Ro and anti-SSB/La. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
*Laboratory findings consistent with the diagnosis of Sjögren's syndrome include:<ref name="pmid24162151">{{cite journal |vauthors=Ramos-Casals M, Brito-Zerón P, Solans R, Camps MT, Casanovas A, Sopeña B, Díaz-López B, Rascón FJ, Qanneta R, Fraile G, Pérez-Alvarez R, Callejas JL, Ripoll M, Pinilla B, Akasbi M, Fonseca E, Canora J, Nadal ME, de la Red G, Fernández-Regal I, Jiménez-Heredia I, Bosch JA, Ayala MD, Morera-Morales L, Maure B, Mera A, Ramentol M, Retamozo S, Kostov B |title=Systemic involvement in primary Sjogren's syndrome evaluated by the EULAR-SS disease activity index: analysis of 921 Spanish patients (GEAS-SS Registry) |journal=Rheumatology (Oxford) |volume=53 |issue=2 |pages=321–31 |date=February 2014 |pmid=24162151 |doi=10.1093/rheumatology/ket349 |url=}}</ref><ref name="pmid23436818">{{cite journal |vauthors=Yazdany J, Schmajuk G, Robbins M, Daikh D, Beall A, Yelin E, Barton J, Carlson A, Margaretten M, Zell J, Gensler LS, Kelly V, Saag K, King C |title=Choosing wisely: the American College of Rheumatology's Top 5 list of things physicians and patients should question |journal=Arthritis Care Res (Hoboken) |volume=65 |issue=3 |pages=329–39 |date=March 2013 |pmid=23436818 |pmc=4106486 |doi=10.1002/acr.21930 |url=}}</ref><ref name="pmid26766898">{{cite journal |vauthors=Beckman KA, Luchs J, Milner MS |title=Making the diagnosis of Sjögren's syndrome in patients with dry eye |journal=Clin Ophthalmol |volume=10 |issue= |pages=43–53 |date=2016 |pmid=26766898 |pmc=4699514 |doi=10.2147/OPTH.S80043 |url=}}</ref><ref name="pmid28367079">{{cite journal |vauthors=Both T, Dalm VA, van Hagen PM, van Daele PL |title=Reviewing primary Sjögren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment |journal=Int J Med Sci |volume=14 |issue=3 |pages=191–200 |date=2017 |pmid=28367079 |pmc=5370281 |doi=10.7150/ijms.17718 |url=}}</ref> | |||
**Elevated [[erythrocyte sedimentation rate]] ([[Erythrocyte sedimentation rate|ESR]]) | |||
**[[Anemia]] | |||
**[[Leukopenia]] | |||
**[[Thrombocytopenia]] | |||
**[[Eosinophilia]] | |||
**[[Hypergammaglobulinemia]] | |||
**Presence of anti-SSA/Ro, anti-SSB/La | |||
**Presence of [[rheumatoid factor]] (RF) | |||
**Presence of anti–alpha-fodrin antibody (diagnostic marker of juvenile Sjögren's syndrome) | |||
**Increasing [[creatinine]] ([[Creatinine|Cr]]) level | |||
**[[Proteinuria]] | |||
**[[Urinary casts]] | |||
**[[Hematuria]] | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Medicine]] | |||
[[Category:Immunology]] | [[Category:Immunology]] | ||
[[Category:Rheumatology]] | [[Category:Rheumatology]] | ||
[[Category:Up-To-Date]] | |||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of Sjögren's syndrome include elevated erythrocyte sedimentation rate (ESR), cytopenia, and presence of anti-SSA/Ro and anti-SSB/La.
Laboratory Findings
- Laboratory findings consistent with the diagnosis of Sjögren's syndrome include:[1][2][3][4]
- Elevated erythrocyte sedimentation rate (ESR)
- Anemia
- Leukopenia
- Thrombocytopenia
- Eosinophilia
- Hypergammaglobulinemia
- Presence of anti-SSA/Ro, anti-SSB/La
- Presence of rheumatoid factor (RF)
- Presence of anti–alpha-fodrin antibody (diagnostic marker of juvenile Sjögren's syndrome)
- Increasing creatinine (Cr) level
- Proteinuria
- Urinary casts
- Hematuria
References
- ↑ Ramos-Casals M, Brito-Zerón P, Solans R, Camps MT, Casanovas A, Sopeña B, Díaz-López B, Rascón FJ, Qanneta R, Fraile G, Pérez-Alvarez R, Callejas JL, Ripoll M, Pinilla B, Akasbi M, Fonseca E, Canora J, Nadal ME, de la Red G, Fernández-Regal I, Jiménez-Heredia I, Bosch JA, Ayala MD, Morera-Morales L, Maure B, Mera A, Ramentol M, Retamozo S, Kostov B (February 2014). "Systemic involvement in primary Sjogren's syndrome evaluated by the EULAR-SS disease activity index: analysis of 921 Spanish patients (GEAS-SS Registry)". Rheumatology (Oxford). 53 (2): 321–31. doi:10.1093/rheumatology/ket349. PMID 24162151.
- ↑ Yazdany J, Schmajuk G, Robbins M, Daikh D, Beall A, Yelin E, Barton J, Carlson A, Margaretten M, Zell J, Gensler LS, Kelly V, Saag K, King C (March 2013). "Choosing wisely: the American College of Rheumatology's Top 5 list of things physicians and patients should question". Arthritis Care Res (Hoboken). 65 (3): 329–39. doi:10.1002/acr.21930. PMC 4106486. PMID 23436818.
- ↑ Beckman KA, Luchs J, Milner MS (2016). "Making the diagnosis of Sjögren's syndrome in patients with dry eye". Clin Ophthalmol. 10: 43–53. doi:10.2147/OPTH.S80043. PMC 4699514. PMID 26766898.
- ↑ Both T, Dalm VA, van Hagen PM, van Daele PL (2017). "Reviewing primary Sjögren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment". Int J Med Sci. 14 (3): 191–200. doi:10.7150/ijms.17718. PMC 5370281. PMID 28367079.