Whipple's disease: Difference between revisions

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'''For patient information, click [[Whipple's disease (patient information)|here]]'''
 
{{CMG}}; {{AE}} {{SSH}}
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  | MeshID        = D008061
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{{Whipple's disease}}
{{Whipple's disease}}


'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
{{SK}} Intestinal lipodystrophy; Whipple disease
 
==[[Whipple's disease overview|Overview]]==
 
==[[Whipple's disease historical perspective|Historical Perspective]]==
 
==[[Whipple's disease classification|Classification]]==
 
==[[Whipple's disease pathophysiology|Pathophysiology]]==
 
==[[Whipple's disease causes|Causes]]==


{{CMG}}
==[[Whipple's disease differential diagnosis|Differentiating Whipple's disease from other Diseases]]==


==Overview==
==[[Whipple's disease epidemiology and demographics|Epidemiology and Demographics]]==
Weight loss, diarrhea, joint pain, and arthritis are common presenting symptoms, but the presentation can be highly variable and approximately 15% of patients do not have these classic signs and symptoms.<ref name=Bai_2004>{{cite journal |author=Bai J, Mazure R, Vazquez H, Niveloni S, Smecuol E, Pedreira S, Mauriño E |title=Whipple's disease |journal=Clin Gastroenterol Hepatol |volume=2 |issue=10 |pages=849-60 |year=2004 |pmid=15476147}}</ref>. When recognized and treated, Whipple's disease can usually be cured with long-term antibiotic therapy; untreated the disease is ultimately fatal.


==Mnemonics==
==[[Whipple's disease risk factors|Risk Factors]]==
<b>W H I P P L E S</b>
*[[Weight Loss]]
*[[Hyperpigmentation]] of the skin
*Infection with [[Tropheryma whipplei]]
*PAS positive granules in [[macrophage]]
*[[Polyarthritis]]
*[[Lymphadenopathy]]
*[[Enteric]] Involvement
*[[Steatorrhea]]


==Symptoms==
==[[Whipple's disease screening|Screening]]==
 
==[[Whipple's disease natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


==Diagnosis==
==Diagnosis==
Common clinical signs and symptoms of Whipple's disease include weight loss, diarrhea, joint pain or arthritis, fever, and [[adenopathy]]. Diagnosis is made by intestinal [[biopsy]], which reveals presence of the organism as [[Periodic acid-Schiff|PAS]]-positive [[macrophage]] inclusions. [[Immunohistochemical]] staining for antibodies against <i>T. whipplei</i> has been used to detect the organism in a variety if tissues, and a confirmatory [[PCR]]-based assay is also available.
[[Whipple's disease history and symptoms|History and Symptoms]] | [[Whipple's disease physical examination|Physical Examination]] | [[Whipple's disease laboratory findings|Laboratory Findings]] | [[Whipple's disease electrocardiogram|Electrocardiogram]] | [[Whipple's disease x ray|X Ray]] | [[Whipple's disease CT|CT]] | [[Whipple's disease MRI|MRI]] | [[Whipple's disease ultrasound|Ultrasound]] | [[Whipple's disease other imaging findings|Other Imaging Findings]] | [[Whipple's disease other diagnostic studies|Other Diagnostic Studies]]
 
[[Endoscopy]] of the [[duodenum]] and [[jejunum]] can reveal pale yellow shaggy mucosa with erythematous eroded patches in patients with classic intestinal Whipple's disease, and small bowel [[X-ray]]s may show some thickened folds.


==Treatment==
==Treatment==
[[Whipple's disease medical therapy|Medical Therapy]] | [[Whipple's disease surgery|Surgery]] | [[Whipple's disease primary prevention|Primary Prevention]] | [[Whipple's disease secondary prevention|Secondary Prevention]] | [[Whipple's disease cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Whipple's disease future or investigational therapies|Future or Investigational Therapies]]


==References==
==Case Studies==
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[[Whipple's disease case study one|Case #1]]
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==External links==
==External Links==
* [http://digestive.niddk.nih.gov/ddiseases/pubs/whipple/ NIH]
* [http://digestive.niddk.nih.gov/ddiseases/pubs/whipple/ NIH]
* [http://www.merck.com/mmhe/sec09/ch125/ch125e.html Merck]
​​
 
 
{{Gastroenterology}}
[[de:Morbus Whipple]]
[[es:Enfermedad de Whipple]]
[[fr:Maladie de Whipple]]
[[it:Morbo di Whipple]]
[[nl:Ziekte van Whipple]]
[[pl:Choroba Whipple'a]]
[[pt:Doença de Whipple]]
[[sv:Whipples sjukdom]]
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}


[[Category:Digestive diseases]]
[[Category:Medicine]]
[[Category:Gastroenterology]]
[[Category:Gastroenterology]]
[[Category:Disease]]
[[Category:Infectious disease]]
[[Category:Mature chapter]]
[[Category:Up-To-Date]]

Latest revision as of 00:44, 30 July 2020

For patient information, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Whipple's disease
light microscopy of small intestine;Whipples Disease: enlarged villus with abundant macrophages
ICD-10 K90.8
ICD-9 040.2
DiseasesDB 14124
MedlinePlus 000209
MeSH D008061

Whipple's disease Microchapters

Home

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Overview

Historical Perspective

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Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

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Physical Examination

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Electrocardiogram

X Ray

CT

MRI

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Synonyms and keywords: Intestinal lipodystrophy; Whipple disease

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Whipple's disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

External Links

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