Renal agenesis natural history, complications and prognosis: Difference between revisions
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{{Renal agenesis}} | {{Renal agenesis}} | ||
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== Overview == | |||
Complications of unilateral renal agenesis (URA) may include signs of [[Renal insufficiency|renal injury]] such as: [[hypertension]], [[microalbuminuria]] and [[Chronic renal failure|chronic kidney disease]]. [[Prognosis]] of bilateral renal agenesis (BRA) is extremely poor, and the [[mortality rate]] is 100% without [[Prenatal development|prenatal]] therapy with serial amnioinfusion. | |||
== Natural History, Complications, and Prognosis == | |||
=== Natural History === | |||
Patients with unilateral renal agenesis (URA) may usually be [[asymptomatic]] but may progress to [[renal insufficiency]] and [[End stage renal disease|end stage renal disease (ESRD)]].<ref name="pmid30734167">{{cite journal| author=Xu Q, Wu H, Zhou L, Xie J, Zhang W, Yu H | display-authors=etal| title=The clinical characteristics of Chinese patients with unilateral renal agenesis. | journal=Clin Exp Nephrol | year= 2019 | volume= 23 | issue= 6 | pages= 792-798 | pmid=30734167 | doi=10.1007/s10157-019-01704-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30734167 }} </ref> | |||
=== Complications === | |||
Complications of unilateral renal agenesis (URA) may include signs of [[Renal insufficiency|renal injury]] such as:<ref name="pmid23449343">{{cite journal| author=Westland R, Schreuder MF, Ket JC, van Wijk JA| title=Unilateral renal agenesis: a systematic review on associated anomalies and renal injury. | journal=Nephrol Dial Transplant | year= 2013 | volume= 28 | issue= 7 | pages= 1844-55 | pmid=23449343 | doi=10.1093/ndt/gft012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23449343 }} </ref> | |||
* [[Hypertension]] (16%) | |||
* [[Microalbuminuria]] (21%) | |||
* [[Glomerular filtration rate|GFR]] <60 mL/min/1.73 m² ([[Chronic renal failure|chronic kidney disease]]) (10%) | |||
=== Prognosis === | |||
* [[Prognosis]] of bilateral renal agenesis (BRA) is extremely poor, and the [[mortality rate]] is 100% without [[Prenatal development|prenatal]] therapy with serial amnioinfusion.<ref name="pmid31098643">{{cite journal| author=Huber C, Shazly SA, Blumenfeld YJ, Jelin E, Ruano R| title=Update on the Prenatal Diagnosis and Outcomes of Fetal Bilateral Renal Agenesis. | journal=Obstet Gynecol Surv | year= 2019 | volume= 74 | issue= 5 | pages= 298-302 | pmid=31098643 | doi=10.1097/OGX.0000000000000670 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31098643 }} </ref> | |||
*URA has a better [[prognosis]] compared to BRA.<ref name="pmid24524801">{{cite journal| author=Dias T, Sairam S, Kumarasiri S| title=Ultrasound diagnosis of fetal renal abnormalities. | journal=Best Pract Res Clin Obstet Gynaecol | year= 2014 | volume= 28 | issue= 3 | pages= 403-15 | pmid=24524801 | doi=10.1016/j.bpobgyn.2014.01.009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24524801 }} </ref> | |||
==References== | ==References== | ||
Latest revision as of 11:25, 1 August 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
Complications of unilateral renal agenesis (URA) may include signs of renal injury such as: hypertension, microalbuminuria and chronic kidney disease. Prognosis of bilateral renal agenesis (BRA) is extremely poor, and the mortality rate is 100% without prenatal therapy with serial amnioinfusion.
Natural History, Complications, and Prognosis
Natural History
Patients with unilateral renal agenesis (URA) may usually be asymptomatic but may progress to renal insufficiency and end stage renal disease (ESRD).[1]
Complications
Complications of unilateral renal agenesis (URA) may include signs of renal injury such as:[2]
- Hypertension (16%)
- Microalbuminuria (21%)
- GFR <60 mL/min/1.73 m² (chronic kidney disease) (10%)
Prognosis
- Prognosis of bilateral renal agenesis (BRA) is extremely poor, and the mortality rate is 100% without prenatal therapy with serial amnioinfusion.[3]
- URA has a better prognosis compared to BRA.[4]
References
- ↑ Xu Q, Wu H, Zhou L, Xie J, Zhang W, Yu H; et al. (2019). "The clinical characteristics of Chinese patients with unilateral renal agenesis". Clin Exp Nephrol. 23 (6): 792–798. doi:10.1007/s10157-019-01704-x. PMID 30734167.
- ↑ Westland R, Schreuder MF, Ket JC, van Wijk JA (2013). "Unilateral renal agenesis: a systematic review on associated anomalies and renal injury". Nephrol Dial Transplant. 28 (7): 1844–55. doi:10.1093/ndt/gft012. PMID 23449343.
- ↑ Huber C, Shazly SA, Blumenfeld YJ, Jelin E, Ruano R (2019). "Update on the Prenatal Diagnosis and Outcomes of Fetal Bilateral Renal Agenesis". Obstet Gynecol Surv. 74 (5): 298–302. doi:10.1097/OGX.0000000000000670. PMID 31098643.
- ↑ Dias T, Sairam S, Kumarasiri S (2014). "Ultrasound diagnosis of fetal renal abnormalities". Best Pract Res Clin Obstet Gynaecol. 28 (3): 403–15. doi:10.1016/j.bpobgyn.2014.01.009. PMID 24524801.