Waldenström's macroglobulinemia: Difference between revisions

	Waldenström's macroglobulinemia Microchapters
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Diagnostic Study of Choice
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Latest revision as of 20:46, 19 August 2020

For patient information on this page, click here Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2], Roukoz A. Karam, M.D.[3], Mirdula Sharma, MBBS [4]; Grammar Reviewer: Natalie Harpenau, B.S.[5]

Synonyms and keywords: Waldenstrom/Waldenstrom's macroglubulinemia (WM), Primary macroglobulinemia, Lymphoplasmacytic lymphoma (LPL), Plasmacytoid lymphocytic lymphoma, Familial Waldenstrom's Macroglobulinaemia, Waldenström macroglobulinaemia

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Waldenström's Macroglobulinemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Treatment

Medical Therapy | Surgery | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Template:WikiDoc Sources

@@ Line 1: / Line 1: @@
 __NOTOC__
+{{Waldenström's macroglobulinemia}}
-{{Waldenström's macroglobulinemia}}
 '''For patient information on this page, click [[Waldenström's macroglobulinemia(patient information)|here]]'''
+{{CMG}}; {{AE}} {{S.M.}}, {{RAK}}, {{MGS}}; {{GRR}} {{Nat}}
-{{CMG}}{{AE}} {{MGS}}
+{{SK}} Waldenstrom/Waldenstrom's macroglubulinemia (WM), Primary [[macroglobulinemia]], [[Lymphoplasmacytic lymphoma]] (LPL), [[Plasmacytoid]] [[lymphocytic lymphoma]], [[Familial]] Waldenstrom's Macroglobulinaemia, Waldenström macroglobulinaemia
-{{SK}} Primary macroglobulinemia; B-cell lymphoproliferative disease; Lymphoplasmacytoid lymphoma, Lymphoplasmacytoid Lymphomas; Macroglobulinemia; Plasmacytoid lymphocytic lymphoma; Familial Waldenstrom's Macroglobulinaemia; Familial Waldenstrom Macroglobulinaemia
 ==[[Waldenström's macroglobulinemia overview|Overview]]==
 ==[[Waldenström's macroglobulinemia historical perspective|Historical Perspective]]==
-* Waldenström's macroglobulinemia was first discovered by Jan G. Waldenström, a Swedish physician in 1944 in two patients with bleeding from the nose and mouth, anemia, decreased levels of fibrinogen in the blood (hypofibrinogenemia), swollen lymph nodes, neoplastic plasma cells in bone marrow, and increased viscosity of the blood due to increased levels of a class of heavy proteins called macroglobulins.<ref name="wiki"/>
+==[[Waldenström's macroglobulinemia classification|Classification]]==
 ==[[Waldenström's macroglobulinemia pathophysiology|Pathophysiology]]==
 ==[[Waldenström's macroglobulinemia causes|Causes]]==
-*The most common causes are a [[somatic mutation]] in [[MYD88]] (90% of patients) and a somatic mutation in [[CXCR4]] (27% of patients).<ref>{{Cite journal | doi = 10.1182/blood-2013-09-525808| title = The genomic landscape of Waldenstrom macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis| journal = Blood| volume = 123| issue = 11| pages = 1637| year = 2013| last1 = Hunter | first1 = Z. R.| last2 = Xu | first2 = L.| last3 = Yang | first3 = G.| last4 = Zhou | first4 = Y.| last5 = Liu | first5 = X.| last6 = Cao | first6 = Y.| last7 = Manning | first7 = R. J.| last8 = Tripsas | first8 = C.| last9 = Patterson | first9 = C. J.| last10 = Sheehy | first10 = P.| last11 = Treon | first11 = S. P.}}</ref>
-==[[Waldenström's macroglobulinemia differential diagnosis|Differentiating Waldenström's macroglobulinemia from other Diseases]]==
+==[[Waldenström's macroglobulinemia differential diagnosis|Differentiating Waldenström's Macroglobulinemia from other Diseases]]==
 ==[[Waldenström's macroglobulinemia epidemiology and demographics|Epidemiology and Demographics]]==
@@ Line 28: / Line 27: @@
 ==[[Waldenström's macroglobulinemia natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
-==Diagnosis==
+==[[Diagnosis]]==
-[[Waldenström's macroglobulinemia history and symptoms|History and Symptoms]] | [[Waldenström's macroglobulinemia physical examination|Physical Examination]] | [[Waldenström's macroglobulinemia laboratory findings|Laboratory Findings]] | [[Waldenström's macroglobulinemia bone_marrow_aspiration_and_biopsy|Bone Marrow Aspiration and Biopsy]] | [[Waldenström's macroglobulinemia electrophoresis_and_immunofixation|Electrophoresis and Immunofixation]] | [[Waldenström's macroglobulinemia chest x ray|Chest X Ray]] | [[Waldenström's macroglobulinemia CT|CT]] | [[Waldenström's macroglobulinemia MRI|MRI]] | [[Waldenström's macroglobulinemia echocardiography_or ultrasound|Echocardiography or Ultrasound]] | [[Waldenström's macroglobulinemia other imaging findings|Other Imaging Findings]] | [[Waldenström's macroglobulinemia other diagnostic studies|Other Diagnostic Studies]]
+[[Waldenström's macroglobulinemia diagnostic study of choice|Diagnostic Study of Choice]] | [[Waldenström's macroglobulinemia history and symptoms|History and Symptoms]] | [[Waldenström's macroglobulinemia physical examination|Physical Examination]] | [[Waldenström's macroglobulinemia laboratory findings|Laboratory Findings]] | [[Waldenström's macroglobulinemia electrocardiogram|Electrocardiogram]] | [[Waldenström's macroglobulinemia chest x ray|Chest X Ray]] | [[Waldenström's macroglobulinemia CT|CT]] | [[Waldenström's macroglobulinemia MRI|MRI]] | [[Waldenström's macroglobulinemia Electrocardiography or Ultrasound|Electrocardiography or Ultrasound]] | [[Waldenström's macroglobulinemia PET|PET]] | [[Waldenström's macroglobulinemia Other Diagnostic Studies|Other Diagnostic Studies]]
 ==Treatment==
-[[Waldenström's macroglobulinemia medical therapy|Medical Therapy]] | [[Waldenström's macroglobulinemia surgery|Surgery]] | [[Waldenström's macroglobulinemia primary prevention|Primary Prevention]] | [[Waldenström's macroglobulinemia secondary prevention|Secondary Prevention]] | [[Waldenström's macroglobulinemia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] |  [[Waldenström's macroglobulinemia future or investigational therapies|Future or Investigational Therapies]]
+[[Waldenström's macroglobulinemia medical therapy|Medical Therapy]] | [[Waldenström's macroglobulinemia surgery| Surgery]] | [[Waldenström's macroglobulinemia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Waldenström's macroglobulinemia future or investigational therapies|Future or Investigational Therapies]]
 ==Case Studies==
 [[Waldenström's macroglobulinemia case study one|Case #1]]

v t e Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208)
CFU-GM/ and other granulocytes	Template:Navbox subgroup
MEP	Template:Navbox subgroup
CFU-Mast	Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis)
Multiple/unknown	AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) · MP (Myelofibrosis) · Acute biphenotypic leukaemia
See also hematology, lymphoid malignancy

Waldenström's macroglobulinemia: Difference between revisions

Latest revision as of 20:46, 19 August 2020

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