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'''For patient information on this page, click [[Waldenström's macroglobulinemia(patient information)|here]]'''  
'''For patient information on this page, click [[Waldenström's macroglobulinemia(patient information)|here]]'''  
{{CMG}}{{AE}}{{S.M.}} {{RAK}}, {{MGS}}
{{CMG}}; {{AE}} {{S.M.}}, {{RAK}}, {{MGS}}; {{GRR}} {{Nat}}


{{SK}} Waldenstrom/Waldenstrom's macroglubulinemia (WM), Primary macroglobulinemia, Lymphoplasmacytic lymphoma (LPL), Plasmacytoid lymphocytic lymphoma, Familial Waldenstrom's Macroglobulinaemia, Waldenström macroglobulinaemia  
{{SK}} Waldenstrom/Waldenstrom's macroglubulinemia (WM), Primary [[macroglobulinemia]], [[Lymphoplasmacytic lymphoma]] (LPL), [[Plasmacytoid]] [[lymphocytic lymphoma]], [[Familial]] Waldenstrom's Macroglobulinaemia, Waldenström macroglobulinaemia  


==[[Waldenström's macroglobulinemia overview|Overview]]==
==[[Waldenström's macroglobulinemia overview|Overview]]==
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==[[Diagnosis]]==
==[[Diagnosis]]==
==Diagnostic criteria of Waldenstrom Macroglobulinemia==
[[Waldenström's macroglobulinemia diagnostic study of choice|Diagnostic Study of Choice]] | [[Waldenström's macroglobulinemia history and symptoms|History and Symptoms]] | [[Waldenström's macroglobulinemia physical examination|Physical Examination]] | [[Waldenström's macroglobulinemia laboratory findings|Laboratory Findings]] | [[Waldenström's macroglobulinemia electrocardiogram|Electrocardiogram]] | [[Waldenström's macroglobulinemia chest x ray|Chest X Ray]] | [[Waldenström's macroglobulinemia CT|CT]] | [[Waldenström's macroglobulinemia MRI|MRI]] | [[Waldenström's macroglobulinemia Electrocardiography or Ultrasound|Electrocardiography or Ultrasound]] | [[Waldenström's macroglobulinemia PET|PET]] | [[Waldenström's macroglobulinemia Other Diagnostic Studies|Other Diagnostic Studies]]
In September 26-30, 2002, in Athens, Greece,the Second International Workshop was held in which the following diagnostic criteria for Waldenstrom's Macroglobulinemia was proposed:
#IgM monoclonal protein of any concentration.
#Bone marrow infiltration by small lymphocytes showing plasmacytoid/plasma-cell differentiation.
#Intertrabecular pattern of bone marrow infiltration.
#Surface IgM+, CD5±, CD10−, CD19+, CD20+, CD22+, CD23−, CD25+, CD27+, FMC7+, CD103−, CD138 immunophenotype.
*Not all the diagnostic tests mentioned are performed in a WM patient. A doctor takes into account the following factors before choosing diagnostic tests in a particular patient:
**Suspected type of cancer.
**Signs and symptoms.
**Age.
**Medical condition of the patient.
**Results of earlier medical tests.
[[Waldenström's macroglobulinemia diagnostic study of choice|Diagnostic Study of Choice]] | [[Waldenström's macroglobulinemia history and symptoms|History and Symptoms]] | [[Waldenström's macroglobulinemia physical examination|Physical Examination]] | [[Waldenström's macroglobulinemia laboratory findings|Laboratory Findings]] | [[Waldenström's macroglobulinemia electrocardiogram|Electrocardiogram]] | [[Waldenström's macroglobulinemia chest x ray|Chest X Ray]] | [[Waldenström's macroglobulinemia CT|CT]] | [[Waldenström's macroglobulinemia MRI|MRI]] | [[Waldenström's macroglobulinemia Electrocardiography or Ultrasound|Electrocardiography or Ultrasound]] | [[Waldenström's macroglobulinemia Other Imaging Findings|Other Imaging Findings]] | [[Waldenström's macroglobulinemia Other Diagnostic Studies|Other Diagnostic Studies]]


==Treatment==
==Treatment==

Latest revision as of 20:46, 19 August 2020

Waldenström's macroglobulinemia Microchapters

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Overview

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Epidemiology and Demographics

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Diagnosis

Diagnostic Study of Choice

History and Symptoms

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Laboratory Findings

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Case #1

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For patient information on this page, click here Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2], Roukoz A. Karam, M.D.[3], Mirdula Sharma, MBBS [4]; Grammar Reviewer: Natalie Harpenau, B.S.[5]

Synonyms and keywords: Waldenstrom/Waldenstrom's macroglubulinemia (WM), Primary macroglobulinemia, Lymphoplasmacytic lymphoma (LPL), Plasmacytoid lymphocytic lymphoma, Familial Waldenstrom's Macroglobulinaemia, Waldenström macroglobulinaemia

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Waldenström's Macroglobulinemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | Chest X Ray | CT | MRI | Electrocardiography or Ultrasound | PET | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1



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