Bradycardia pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
[[Bradycardia]] generally results from [[sinus node dysfunction]] and [[atrioventricular node|AV node dysfunction]]. However, other pathophysiologic conditions can also result in [[bradycardia]] such as acute [[Myocardial infarction]], [[obstructive sleep apnea]], exaggerated vagal activity, increased [[intracranial pressure]], and infectious diseases such as [[Lyme disease]], [[rocky Mountain spotted fever|rocky mountain spotted fever]], [[chagas disease]], [[psittacosis]], [[Q fever]], and [[typhoid fever]]. | |||
==Pathophysiology== | ==Pathophysiology== | ||
The underlying mechanism is not clinically relevant to the treatment. | |||
There are generally two types of problems that result in | There are generally two types of problems that result in [[bradycardia]]: | ||
===Disorders of the sinus node=== | |||
*Impaired [[automaticity]] - [[Sinus node]] dysfunction/[[sick sinus syndrome]])<ref name="pmid6620520">{{cite journal| author=Alpert MA, Flaker GC| title=Arrhythmias associated with sinus node dysfunction. Pathogenesis, recognition, and management. | journal=JAMA | year= 1983 | volume= 250 | issue= 16 | pages= 2160-6 | pmid=6620520 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6620520 }} </ref><ref name="BrodskyWu1977">{{cite journal|last1=Brodsky|first1=Michael|last2=Wu|first2=Delon|last3=Denes|first3=Pablo|last4=Kanakis|first4=Charles|last5=Rosen|first5=Kenneth M.|title=Arrhythmias documented by 24 hour continuous electrocardiographic monitoring in 50 male medical students without apparent heart disease|journal=The American Journal of Cardiology|volume=39|issue=3|year=1977|pages=390–395|issn=00029149|doi=10.1016/S0002-9149(77)80094-5}}</ref> | |||
===Disorders of the atrioventricular node (AV node)=== | |||
[[Sinus bradycardia | *[[Atrioventricular]] conduction disturbances result from impaired conduction in the [[AV node]], or anywhere below it, such as in the [[bundle of HIS]]. | ||
Sinus bradycardia can also be seen in these pathophysiologic settings:<ref name="pmid29630253">{{cite journal| author=| title=StatPearls | journal= | year= 2020 | volume= | issue= | pages= | pmid=29630253 | doi= | pmc= | url= }}</ref><ref name="NofLuria2007">{{cite journal|last1=Nof|first1=Eyal|last2=Luria|first2=David|last3=Brass|first3=Dovrat|last4=Marek|first4=Dina|last5=Lahat|first5=Hadas|last6=Reznik-Wolf|first6=Haya|last7=Pras|first7=Elon|last8=Dascal|first8=Nathan|last9=Eldar|first9=Michael|last10=Glikson|first10=Michael|title=Point Mutation in the HCN4 Cardiac Ion Channel Pore Affecting Synthesis, Trafficking, and Functional Expression Is Associated With Familial Asymptomatic Sinus Bradycardia|journal=Circulation|volume=116|issue=5|year=2007|pages=463–470|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.107.706887}}</ref> | |||
===Acute Myocardial infarction=== | ===Acute Myocardial infarction=== | ||
*Patients with acute [[myocardial infarction]], especially those with the [[ | *Patients with acute [[myocardial infarction]], especially those with the right [[coronary artery]], are affected by [[bradycardia]] as it supplies the [[SA node]].<ref name="pmid31060863">{{cite journal |vauthors=Davis WT, Montrief T, Koyfman A, Long B |title=Dysrhythmias and heart failure complicating acute myocardial infarction: An emergency medicine review |journal=Am J Emerg Med |volume=37 |issue=8 |pages=1554–1561 |date=August 2019 |pmid=31060863 |doi=10.1016/j.ajem.2019.04.047 |url=}}</ref> | ||
===Obstructive sleep apnea=== | ===Obstructive sleep apnea=== | ||
| Line 32: | Line 32: | ||
===Exaggerated vagal activity=== | ===Exaggerated vagal activity=== | ||
*Vasovagal responses may be associated with severe [[bradycardia]] due to elevated [[Parasympathetic nervous system|parasympathetic]] involvement and [[sympathetic]] suppression of the [[SA node]]. These stimuli include [[carotid sinus]] stimulation, [[vomiting]], [[coughing]], and [[Valsalva maneuver]]. | *[[Vasovagal]] responses may be associated with severe [[bradycardia]] due to elevated [[Parasympathetic nervous system|parasympathetic]] involvement and [[sympathetic]] suppression of the [[SA node]]. These stimuli include [[carotid sinus]] stimulation, [[vomiting]], [[coughing]], and [[Valsalva maneuver]]. | ||
===Increased intracranial pressure=== | ===Increased intracranial pressure=== | ||
*Increased intracranial pressure should be excluded when [[sinus bradycardia]] arises in a patient with neurological dysfunction.[[Sinus bradycardia]] is often associated with damage to the [[cervical]] or [[thoracic]] spine, where the [[sympathetic]] denervation of the heart leaves an uncontested [[parasympathetic]] tone.<ref name="pmid7566833">{{cite journal| author=Gilson GJ, Miller AC, Clevenger FW, Curet LB| title=Acute spinal cord injury and neurogenic shock in pregnancy. | journal=Obstet Gynecol Surv | year= 1995 | volume= 50 | issue= 7 | pages= 556-60 | pmid=7566833 | doi=10.1097/00006254-199507000-00022 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7566833 }} </ref> | *Increased intracranial pressure should be excluded when [[sinus bradycardia]] arises in a patient with neurological dysfunction. [[Sinus bradycardia]] is often associated with damage to the [[cervical]] or [[thoracic]] spine, where the [[sympathetic]] denervation of the heart leaves an uncontested [[parasympathetic]] tone.<ref name="pmid7566833">{{cite journal| author=Gilson GJ, Miller AC, Clevenger FW, Curet LB| title=Acute spinal cord injury and neurogenic shock in pregnancy. | journal=Obstet Gynecol Surv | year= 1995 | volume= 50 | issue= 7 | pages= 556-60 | pmid=7566833 | doi=10.1097/00006254-199507000-00022 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7566833 }} </ref> | ||
===Infectious causes=== | ===Infectious causes=== | ||
*Infectious agents associated with relative [[sinus bradycardia]] include [[Lyme disease]], [[Chagas disease]], [[legionella]], [[psittacosis]], [[Q fever]], [[typhoid fever]], [[typhus]], [[babesiosis]], [[malaria]], [[leptospirosis]], [[yellow fever]], [[dengue fever]], [[Viral hemorrhagic fever|viral hemorrhagic fevers]], [[trichinosis]], and [[Rocky Mountain spotted fever|Rocky Mountain Spotted fever]]. <ref name="pmid11284920">{{cite journal| author=Cunha BA| title=The diagnostic significance of relative bradycardia in infectious disease. | journal=Clin Microbiol Infect | year= 2000 | volume= 6 | issue= 12 | pages= 633-4 | pmid=11284920 | doi=10.1046/j.1469-0691.2000.0194f.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11284920 }} </ref><ref name="pmid15949188">{{cite journal| author=Puljiz I, Beus A, Kuzman I, Seiwerth S| title=Electrocardiographic changes and myocarditis in trichinellosis: a retrospective study of 154 patients. | journal=Ann Trop Med Parasitol | year= 2005 | volume= 99 | issue= 4 | pages= 403-11 | pmid=15949188 | doi=10.1179/136485905X36307 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15949188 }} </ref> | *[[Infection|Infectious]] agents associated with relative [[sinus bradycardia]] include [[Lyme disease]], [[Chagas disease]], [[legionella]], [[psittacosis]], [[Q fever]], [[typhoid fever]], [[typhus]], [[babesiosis]], [[malaria]], [[leptospirosis]], [[yellow fever]], [[dengue fever]], [[Viral hemorrhagic fever|viral hemorrhagic fevers]], [[trichinosis]], and [[Rocky Mountain spotted fever|Rocky Mountain Spotted fever]]. <ref name="pmid11284920">{{cite journal| author=Cunha BA| title=The diagnostic significance of relative bradycardia in infectious disease. | journal=Clin Microbiol Infect | year= 2000 | volume= 6 | issue= 12 | pages= 633-4 | pmid=11284920 | doi=10.1046/j.1469-0691.2000.0194f.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11284920 }} </ref><ref name="pmid15949188">{{cite journal| author=Puljiz I, Beus A, Kuzman I, Seiwerth S| title=Electrocardiographic changes and myocarditis in trichinellosis: a retrospective study of 154 patients. | journal=Ann Trop Med Parasitol | year= 2005 | volume= 99 | issue= 4 | pages= 403-11 | pmid=15949188 | doi=10.1179/136485905X36307 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15949188 }} </ref> | ||
===Microscopic Pathology=== | |||
*On [[microscopic]] [[histopathological]] analysis, a few patients with sinus [[bradycardia]] may show no nodal [[histopathology]], yet some [[microscopic]] findings are associated with the condition which includes the following:<ref name="pmid17646576">{{cite journal| author=Nof E, Luria D, Brass D, Marek D, Lahat H, Reznik-Wolf H | display-authors=etal| title=Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia. | journal=Circulation | year= 2007 | volume= 116 | issue= 5 | pages= 463-70 | pmid=17646576 | doi=10.1161/CIRCULATIONAHA.107.706887 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17646576 }}</ref><ref name="pmid15302799">{{cite journal| author=Sanders P, Kistler PM, Morton JB, Spence SJ, Kalman JM| title=Remodeling of sinus node function in patients with congestive heart failure: reduction in sinus node reserve. | journal=Circulation | year= 2004 | volume= 110 | issue= 8 | pages= 897-903 | pmid=15302799 | doi=10.1161/01.CIR.0000139336.69955.AB | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15302799 }}</ref> | |||
**[[Nodal (protein)|Nodal]] cell reduction | |||
**[[Nodal (protein)|Nodal]] cell and [[fibrosis]] | |||
**[[Amyloidosis]] in the [[Nodal (protein)|nodal]] region | |||
**[[Sinus node]] [[hypoplasia]] | |||
==References== | ==References== | ||
Latest revision as of 14:46, 23 September 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M.Umer Tariq [2] Ibtisam Ashraf, M.B.B.S.[3]
Overview
Bradycardia generally results from sinus node dysfunction and AV node dysfunction. However, other pathophysiologic conditions can also result in bradycardia such as acute Myocardial infarction, obstructive sleep apnea, exaggerated vagal activity, increased intracranial pressure, and infectious diseases such as Lyme disease, rocky mountain spotted fever, chagas disease, psittacosis, Q fever, and typhoid fever.
Pathophysiology
The underlying mechanism is not clinically relevant to the treatment.
There are generally two types of problems that result in bradycardia:
Disorders of the sinus node
- Impaired automaticity - Sinus node dysfunction/sick sinus syndrome)[1][2]
Disorders of the atrioventricular node (AV node)
- Atrioventricular conduction disturbances result from impaired conduction in the AV node, or anywhere below it, such as in the bundle of HIS.
Sinus bradycardia can also be seen in these pathophysiologic settings:[3][4]
Acute Myocardial infarction
- Patients with acute myocardial infarction, especially those with the right coronary artery, are affected by bradycardia as it supplies the SA node.[5]
Obstructive sleep apnea
- Those with obstructive sleep apnea also have sinus bradycardia, which can be extreme (< 30 beats per minute) during apnea.[6]
Exaggerated vagal activity
- Vasovagal responses may be associated with severe bradycardia due to elevated parasympathetic involvement and sympathetic suppression of the SA node. These stimuli include carotid sinus stimulation, vomiting, coughing, and Valsalva maneuver.
Increased intracranial pressure
- Increased intracranial pressure should be excluded when sinus bradycardia arises in a patient with neurological dysfunction. Sinus bradycardia is often associated with damage to the cervical or thoracic spine, where the sympathetic denervation of the heart leaves an uncontested parasympathetic tone.[7]
Infectious causes
- Infectious agents associated with relative sinus bradycardia include Lyme disease, Chagas disease, legionella, psittacosis, Q fever, typhoid fever, typhus, babesiosis, malaria, leptospirosis, yellow fever, dengue fever, viral hemorrhagic fevers, trichinosis, and Rocky Mountain Spotted fever. [8][9]
Microscopic Pathology
- On microscopic histopathological analysis, a few patients with sinus bradycardia may show no nodal histopathology, yet some microscopic findings are associated with the condition which includes the following:[10][11]
- Nodal cell reduction
- Nodal cell and fibrosis
- Amyloidosis in the nodal region
- Sinus node hypoplasia
References
- ↑ Alpert MA, Flaker GC (1983). "Arrhythmias associated with sinus node dysfunction. Pathogenesis, recognition, and management". JAMA. 250 (16): 2160–6. PMID 6620520.
- ↑ Brodsky, Michael; Wu, Delon; Denes, Pablo; Kanakis, Charles; Rosen, Kenneth M. (1977). "Arrhythmias documented by 24 hour continuous electrocardiographic monitoring in 50 male medical students without apparent heart disease". The American Journal of Cardiology. 39 (3): 390–395. doi:10.1016/S0002-9149(77)80094-5. ISSN 0002-9149.
- ↑ "StatPearls". 2020. PMID 29630253.
- ↑ Nof, Eyal; Luria, David; Brass, Dovrat; Marek, Dina; Lahat, Hadas; Reznik-Wolf, Haya; Pras, Elon; Dascal, Nathan; Eldar, Michael; Glikson, Michael (2007). "Point Mutation in the HCN4 Cardiac Ion Channel Pore Affecting Synthesis, Trafficking, and Functional Expression Is Associated With Familial Asymptomatic Sinus Bradycardia". Circulation. 116 (5): 463–470. doi:10.1161/CIRCULATIONAHA.107.706887. ISSN 0009-7322.
- ↑ Davis WT, Montrief T, Koyfman A, Long B (August 2019). "Dysrhythmias and heart failure complicating acute myocardial infarction: An emergency medicine review". Am J Emerg Med. 37 (8): 1554–1561. doi:10.1016/j.ajem.2019.04.047. PMID 31060863.
- ↑ Caples SM, Rosen CL, Shen WK, Gami AS, Cotts W, Adams M; et al. (2007). "The scoring of cardiac events during sleep". J Clin Sleep Med. 3 (2): 147–54. PMID 17557424.
- ↑ Gilson GJ, Miller AC, Clevenger FW, Curet LB (1995). "Acute spinal cord injury and neurogenic shock in pregnancy". Obstet Gynecol Surv. 50 (7): 556–60. doi:10.1097/00006254-199507000-00022. PMID 7566833.
- ↑ Cunha BA (2000). "The diagnostic significance of relative bradycardia in infectious disease". Clin Microbiol Infect. 6 (12): 633–4. doi:10.1046/j.1469-0691.2000.0194f.x. PMID 11284920.
- ↑ Puljiz I, Beus A, Kuzman I, Seiwerth S (2005). "Electrocardiographic changes and myocarditis in trichinellosis: a retrospective study of 154 patients". Ann Trop Med Parasitol. 99 (4): 403–11. doi:10.1179/136485905X36307. PMID 15949188.
- ↑ Nof E, Luria D, Brass D, Marek D, Lahat H, Reznik-Wolf H; et al. (2007). "Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia". Circulation. 116 (5): 463–70. doi:10.1161/CIRCULATIONAHA.107.706887. PMID 17646576.
- ↑ Sanders P, Kistler PM, Morton JB, Spence SJ, Kalman JM (2004). "Remodeling of sinus node function in patients with congestive heart failure: reduction in sinus node reserve". Circulation. 110 (8): 897–903. doi:10.1161/01.CIR.0000139336.69955.AB. PMID 15302799.