Hirsutism differential diagnosis: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Hirsutism]] | |||
{{CMG}} {{AE}} | {{CMG}} {{AE}} {{Ochuko}}, {{RHN}}, {{AEL}} | ||
==Overview== | ==Overview== | ||
Hirsutism must be differentiated based on the different diseases causing hirsutism such as [[21-hydroxylase deficiency]], [[11β-hydroxylase deficiency|11-β hydroxylase deficiency]], [[3 beta-hydroxysteroid dehydrogenase deficiency|3 beta-hydroxysteroid dehydrogenase deficiency]], [[polycystic ovary syndrome]], [[Cushing's syndrome]], and [[hyperprolactinemia]]. | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Hirsutism must be differentiated | *The diagnosis of hirsutism requires the exclusion of related disorders with peripheral androgen activity. | ||
*Hirsutism starts shortly after puberty with a slow course and progression. | |||
*Hirsutism must be differentiated from other diseases causing excessive hair growth on the body such as [[21-hydroxylase deficiency]], [[11β-hydroxylase deficiency|11-β hydroxylase deficiency]], [[3 beta-hydroxysteroid dehydrogenase deficiency|3 beta-hydroxysteroid dehydrogenase deficiency,]] [[polycystic ovary syndrome]], [[Cushing's syndrome]], and [[hyperprolactinemia]].<ref name="pmid24830586">{{cite journal |vauthors=Hohl A, Ronsoni MF, Oliveira Md |title=Hirsutism: diagnosis and treatment |journal=Arq Bras Endocrinol Metabol |volume=58 |issue=2 |pages=97–107 |year=2014 |pmid=24830586 |doi= |url=}}</ref><ref name="pmid10857554">{{cite journal |vauthors=White PC, Speiser PW |title=Congenital adrenal hyperplasia due to 21-hydroxylase deficiency |journal=Endocr. Rev. |volume=21 |issue=3 |pages=245–91 |year=2000 |pmid=10857554 |doi=10.1210/edrv.21.3.0398 |url=}}</ref><ref name="ISBN:978-0323297387">{{cite book | last = Melmed | first = Shlomo | title = Williams textbook of endocrinology | publisher = Elsevier | location = Philadelphia, PA | year = 2016 | isbn = 978-0323297387 }}=</ref> | |||
{| class="wikitable" | {| class="wikitable" | ||
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* Low [[testosterone]] levels | * Low [[testosterone]] levels | ||
| | | | ||
* [[Hypertension]] | * [[Hypertension]] | ||
* [[hypokalemia]] | |||
* [[Virilization]] | * [[Virilization]] | ||
|- | |- | ||
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* Increased [[prolactin]] | * Increased [[prolactin]] | ||
| | | | ||
* [[Infertility]] | * [[Infertility]] | ||
* [[galactorrhea]] | |||
|} | |} | ||
Latest revision as of 15:15, 8 December 2020
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ogheneochuko Ajari, MB.BS, MS [2], Rasam Hajiannasab M.D.[3], Ahmed Elsaiey, MBBCH [4]
Overview
Hirsutism must be differentiated based on the different diseases causing hirsutism such as 21-hydroxylase deficiency, 11-β hydroxylase deficiency, 3 beta-hydroxysteroid dehydrogenase deficiency, polycystic ovary syndrome, Cushing's syndrome, and hyperprolactinemia.
Differential Diagnosis
- The diagnosis of hirsutism requires the exclusion of related disorders with peripheral androgen activity.
- Hirsutism starts shortly after puberty with a slow course and progression.
- Hirsutism must be differentiated from other diseases causing excessive hair growth on the body such as 21-hydroxylase deficiency, 11-β hydroxylase deficiency, 3 beta-hydroxysteroid dehydrogenase deficiency, polycystic ovary syndrome, Cushing's syndrome, and hyperprolactinemia.[1][2][3]
| Disease name | Steroid status | Other laboratory | Important clinical findings |
|---|---|---|---|
| Non-classic type of 21-hydroxylase deficiency | Increased:
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|
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| 11-β hydroxylase deficiency | Increased:
Decreased: |
|
|
| 3 beta-hydroxysteroid dehydrogenase deficiency | Increased:
Decreased: |
|
|
| Polycystic ovary syndrome |
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| Adrenal tumors |
|
|
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| Ovarian virilizing tumor |
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| Cushing's syndrome |
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| Hyperprolactinemia |
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References
- ↑ Hohl A, Ronsoni MF, Oliveira M (2014). "Hirsutism: diagnosis and treatment". Arq Bras Endocrinol Metabol. 58 (2): 97–107. PMID 24830586. Vancouver style error: initials (help)
- ↑ White PC, Speiser PW (2000). "Congenital adrenal hyperplasia due to 21-hydroxylase deficiency". Endocr. Rev. 21 (3): 245–91. doi:10.1210/edrv.21.3.0398. PMID 10857554.
- ↑ Melmed, Shlomo (2016). Williams textbook of endocrinology. Philadelphia, PA: Elsevier. ISBN 978-0323297387.=