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__NOTOC__
__NOTOC__


{{CMG}}; {{AE}} {{S.M.}}


{{CMG}}; {{AE}} {{S.M.}}




{| class="wikitable"
<ref name="pmid27261907">{{cite journal| author=Mao Y, Yang D, He J, Krasna MJ| title=Epidemiology of Lung Cancer. | journal=Surg Oncol Clin N Am | year= 2016 | volume= 25 | issue= 3 | pages= 439-45 | pmid=27261907 | doi=10.1016/j.soc.2016.02.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27261907  }} </ref>
|+Knowing individual skin type and using the right sunscreen accordingly
 
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|'''Skin type by the Fitzpatrick Scale'''}}
[[File:Atypical Bcell gif.gif|thumb|200px|none|High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.[https://openi.nlm.nih.gov/detailedresult.php?img=PMC2944189_1752-1947-4-300-2&query=waldenstrom+macroglobulinaemia&it=xg&req=4&npos=17 Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.]]]
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|'''Skin color'''}}
 
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|'''Skin tone or other common descriptors'''}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|'''Sun exposure effects''' }}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|'''Recommended sunscreen SPF''' }}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |'''I'''
|Pale white
|Pale or albino, freckles common (Celtic)
|
* Always burns
* Never tans
| rowspan="2" |30+
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |'''II'''
|White
|Light or fair (European)
|
* Always burns
* Rarely tans
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |'''III'''
|White
|Light‐intermediate (Dark European)
|
* Sometimes burns
* Sometimes tans
| rowspan="4" |15+
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |'''IV'''
|Light brown
|Olive with/without brown tint (Mediterranean)
|
* Tans easily
* Burns less
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |'''V'''
|Dark brown
|Brown
|
* Tans easily
* Rarely burns
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |'''VI'''
|Black
|Black
|
* Does not burn
|}


{| class="wikitable"
{|  
|+Different sunscreen recommendations and recommendations' grading according to Canadian Task Force on Preventive Health Care (CTFPHC) GRADE System
|+'''Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders'''
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Sunscreen property}}
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Criteria
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Recommendation}}
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Symptomatic WM
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Grade of Recommendations}}
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Asymptomatic WM
|-
! style="background:#4479BA; color: #FFFFFF;" align="center" + |IgM-Related Disorders
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | SPF (Sun Protection Factor)
! style="background:#4479BA; color: #FFFFFF;" align="center" + |MGUS
|
*An ideal sunscreen should have the following properties:
**Broad-spectrum
**Both UVA & UVB filters
**Atleast SPF 30
|
*Strongly recommended
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Water resistance
|
*Sunscreen providing water-resistance for 40-80 minutes must be worn in following conditions:
**Water immersion
**Excessive sweating
**Contact with sand
**Physical contact causing increased skin friction
|
*Strongly recommended
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Organic vs inorganic sunscreens
|
*Whether the components of sunscreen are organic or inorganic, recommended sunscreen must be broad spectrum with both UVA & UVB filters
|
*Strongly recommended
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Lip protection
|
*Whole lip should be generously covered by high-SPF (>/= 30) and reapplication of lip sunscreen
|
*Strongly recommended
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Sunscreen application
|
*Sunscreen is recommended to be applied according to following guidelines:
**Should be applied liberally (approximately 45 ml) to all the exposed areas
**Strong reapplication within a period of 8 hours is mandatory only after activities that may remove the sunscreen layer such as sweating, swimming, or friction
**Should be applied  before any sun exposure and at least 20 minutes before the water activities
|
*Strongly recommended
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Patient education on sunscreen
|
*Patients should be educated about the meaning of SPF and its effectivesness
|
*Strongly recommended
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Sunscreen safety
! align="center" style="background:#DCDCDC;" + |IgM monoclonal protein
|
| style="background:#F5F5F5;" align="center" + | +
*Sunscreens have a favorable risk-benefit profile, hence, are considered to be safe overall
| style="background:#F5F5F5;" align="center" + | +
*There is still a risk of following few complications due to sunscreen application in some people:
| style="background:#F5F5F5;" align="center" + | +
**Photoallergy (most common, but quite rare)
| style="background:#F5F5F5;" align="center" + | +
**Reproductive toxicity
|
*Strongly recommended
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Sunscreen benefits
! align="center" style="background:#DCDCDC;" + |Bone marrow infiltration
|
| style="background:#F5F5F5;" align="center" + | +
*Prevents photoaging
| style="background:#F5F5F5;" align="center" + | +
*Prevents melanoma and non–melanoma skin cancer
| style="background:#F5F5F5;" align="center" + | -
|
| style="background:#F5F5F5;" align="center" + | -
*Strongly recommended
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Sunscreen vehicle
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to IgM
|
| style="background:#F5F5F5;" align="center" + | +
*Highest SPF and water resistance properties of sunscreen can be obtained by using a '''water-in-oil emulsion''' formulation for sunscreens
| style="background:#F5F5F5;" align="center" + | -
|
| style="background:#F5F5F5;" align="center" + | +
*Weakly recommended
| style="background:#F5F5F5;" align="center" + | -
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Expiry date
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to tumor infiltration
|
| style="background:#F5F5F5;" align="center" + | +
*Avoid using sunscreens past the manufacturer-specified expiry date/recommended period after opening
| style="background:#F5F5F5;" align="center" + | -
*Sunscreens should be stored at normal room temperature in order to ensure their proper stability
| style="background:#F5F5F5;" align="center" + | -
|
| style="background:#F5F5F5;" align="center" + | -
*Weakly recommended
|}<br />
|}
 




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==References==
==Reference==
{{Reflist|2}}
{{Reflist|2}}

Latest revision as of 18:18, 11 December 2020


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]


[1]

High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.


Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders
Criteria Symptomatic WM Asymptomatic WM IgM-Related Disorders MGUS
IgM monoclonal protein + + + +
Bone marrow infiltration + + - -
Symptoms attributable to IgM + - + -
Symptoms attributable to tumor infiltration + - - -




Reference

  1. ↑ Mao Y, Yang D, He J, Krasna MJ (2016). "Epidemiology of Lung Cancer". Surg Oncol Clin N Am. 25 (3): 439–45. doi:10.1016/j.soc.2016.02.001. PMID 27261907.
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