Sandbox:Sara: Difference between revisions

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{{CMG}}; {{AE}} {{S.M.}}
{{CMG}}; {{AE}} {{S.M.}}


[[Microscopic]] [[Features (pattern recognition)|features]] include:


* Non-circumscribed
 
* Highly cellular with cells having following characteristics:
<ref name="pmid27261907">{{cite journal| author=Mao Y, Yang D, He J, Krasna MJ| title=Epidemiology of Lung Cancer. | journal=Surg Oncol Clin N Am | year= 2016 | volume= 25 | issue= 3 | pages= 439-45 | pmid=27261907 | doi=10.1016/j.soc.2016.02.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27261907  }} </ref>
** Monomorphic
 
** Thin
[[File:Atypical Bcell gif.gif|thumb|200px|none|High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.[https://openi.nlm.nih.gov/detailedresult.php?img=PMC2944189_1752-1947-4-300-2&query=waldenstrom+macroglobulinaemia&it=xg&req=4&npos=17 Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.]]]
** Spindly
 
** Scant eosinophilic cytoplasm
 
** Hyperchromatic nuclei (resembling neurofibroma)
{|
* Tight storiform pattern (cells radiating in spokes at right angles around a central point that often contains a vessel) infiltrating deeply into subcutaneous tissue and entraping fat cells to form a characteristic honeycomb pattern
|+'''Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders'''
* Areas of fascicular growth (seen in some cases)
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Criteria
* The early plaque stage may lack the particular storiform pattern
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Symptomatic WM
* Many non-atypical mitotic figures may be present
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Asymptomatic WM
* Non-polarized, thin collagen
! style="background:#4479BA; color: #FFFFFF;" align="center" + |IgM-Related Disorders
* Mild pleomorphism (not significant)
! style="background:#4479BA; color: #FFFFFF;" align="center" + |MGUS
* Focal atypia
|-
* May coexist with giant cell fibroblastoma
! align="center" style="background:#DCDCDC;" + |IgM monoclonal protein
* Absent or rare histiocytes
| style="background:#F5F5F5;" align="center" + | +
* Following cell types are absent:
| style="background:#F5F5F5;" align="center" + | +
** Histiocyte-like cells
| style="background:#F5F5F5;" align="center" + | +
** Foam cells
| style="background:#F5F5F5;" align="center" + | +
** Giant cells
|-
** Other inflammatory cells
! align="center" style="background:#DCDCDC;" + |Bone marrow infiltration
* Different '''variants''' include:
| style="background:#F5F5F5;" align="center" + | +
** Atrophic (depressed lesion)
| style="background:#F5F5F5;" align="center" + | +
** Collagenous (with central thick collagen bundles)
| style="background:#F5F5F5;" align="center" + | -
** Granular cell (S100 negative)
| style="background:#F5F5F5;" align="center" + | -
** Myxoid
|-
** Palisading
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to IgM
** Pigmented
| style="background:#F5F5F5;" align="center" + | +
** Sclerosing
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | -
|-
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to tumor infiltration
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | -
|}<br />
 
 
 
 
 
==Reference==
{{Reflist|2}}

Latest revision as of 18:18, 11 December 2020


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]


[1]

High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.


Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders
Criteria Symptomatic WM Asymptomatic WM IgM-Related Disorders MGUS
IgM monoclonal protein + + + +
Bone marrow infiltration + + - -
Symptoms attributable to IgM + - + -
Symptoms attributable to tumor infiltration + - - -




Reference

  1. ↑ Mao Y, Yang D, He J, Krasna MJ (2016). "Epidemiology of Lung Cancer". Surg Oncol Clin N Am. 25 (3): 439–45. doi:10.1016/j.soc.2016.02.001. PMID 27261907.
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