|
|
| (16 intermediate revisions by one other user not shown) |
| Line 1: |
Line 1: |
| __NOTOC__
| |
| {{Suicidal ideation}}
| |
|
| |
|
| {{CMG}}; {{AE}}
| |
| ==Overview==
| |
| The exact pathogenesis of [disease name] is not fully understood.
| |
|
| |
| OR
| |
|
| |
| It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
| |
|
| |
| OR
| |
|
| |
| [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
| |
|
| |
| OR
| |
|
| |
| Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
| |
|
| |
| OR
| |
|
| |
|
| |
| [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
| |
|
| |
| OR
| |
|
| |
| The progression to [disease name] usually involves the [molecular pathway].
| |
|
| |
| OR
| |
|
| |
| The pathophysiology of [disease/malignancy] depends on the histological subtype.
| |
|
| |
| ==Pathophysiology==
| |
|
| |
| Decreased cerebrospinal fluid (CSF) serotonin levels and serotonin receptor dysfunction are strong risk factors for suicide attempt and completion. Dysfunction in central serotonin systems is associated with a lowered threshold for self-directed and externally directed aggressive behavior. 1976, Asberg et al reported a bimodal distribution of serotonin metabolites (5-HIAA) in the CSF of depressed patients.23 In this study, significantly more of the depressed patients in the "low" CSF 5-HIAA group had attempted suicide compared to the "high" CSF group.23 A five-year follow-up study of depressed patients concluded that patients who attempted suicide before the index admission and who reattempted suicide during the follow-up had significantly lower CSF levels of 5-HIAA.24 To date, more than 20 studies have reported low concentrations of CSF 5-HIAA in suicide attempters with a broad range of diagnoses, making this one of the strongest findings in biological psychiatry. The absolute reduction in the concentration of CSF 5-HIAA appears to correlate well with lethality, increased planning, and medical damage of the suicide attempt.27 The pharmacotherapy of suicidal patients often aims at increasing serotonin availability in the brainstem.
| |
|
| |
| ==Genetics==
| |
| *[Disease name] is transmitted in [mode of genetic transmission] pattern.
| |
| *Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
| |
| *The development of [disease name] is the result of multiple genetic mutations.
| |
| ==Associated Conditions==
| |
|
| |
| ==Gross Pathology==
| |
| *On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
| |
|
| |
| ==Microscopic Pathology==
| |
| *On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
| |
|
| |
| ==References==
| |
| {{Reflist|2}}
| |
|
| |
| {{WH}}
| |
| {{WS}}
| |