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__NOTOC__ | |||
{{CMG}}; {{AE}} {{Joban Ghuman}} | |||
== monoclonal gammopathy of undetermined significance == | |||
\Monoclonal gammopathies are conditions in which abnormal proteins (antibodies) are found in the blood. These proteins are produced from a small number of plasma cells in the bone marrow. Plasma cells are a type of white blood cell. Their main job is to make antibodies to fight infection. | |||
[[File:Monoclonals-gl.png|Monoclonals-gl|link=Special:FilePath/Monoclonals-gl.png]][[File:Monoclonals-gl.png|thumb|Monoclonals-gl|link=Special:FilePath/Monoclonals-gl.png]] | |||
<ref name="pmid27261907">{{cite journal| author=Mao Y, Yang D, He J, Krasna MJ| title=Epidemiology of Lung Cancer. | journal=Surg Oncol Clin N Am | year= 2016 | volume= 25 | issue= 3 | pages= 439-45 | pmid=27261907 | doi=10.1016/j.soc.2016.02.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27261907 }} </ref> | |||
[[File:Atypical Bcell gif.gif|thumb|200px|none|High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.[https://openi.nlm.nih.gov/detailedresult.php?img=PMC2944189_1752-1947-4-300-2&query=waldenstrom+macroglobulinaemia&it=xg&req=4&npos=17 Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.]]] | |||
{| | |||
|+'''Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders''' | |||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Criteria | |||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Symptomatic WM | |||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Asymptomatic WM | |||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |IgM-Related Disorders | |||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |MGUS | |||
|- | |||
! align="center" style="background:#DCDCDC;" + |IgM monoclonal protein | |||
| style="background:#F5F5F5;" align="center" + | + | |||
| style="background:#F5F5F5;" align="center" + | + | |||
| style="background:#F5F5F5;" align="center" + | + | |||
| style="background:#F5F5F5;" align="center" + | + | |||
|- | |||
! align="center" style="background:#DCDCDC;" + |Bone marrow infiltration | |||
| style="background:#F5F5F5;" align="center" + | + | |||
| style="background:#F5F5F5;" align="center" + | + | |||
| style="background:#F5F5F5;" align="center" + | - | |||
| style="background:#F5F5F5;" align="center" + | - | |||
|- | |||
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to IgM | |||
| style="background:#F5F5F5;" align="center" + | + | |||
| style="background:#F5F5F5;" align="center" + | - | |||
| style="background:#F5F5F5;" align="center" + | + | |||
| style="background:#F5F5F5;" align="center" + | - | |||
|- | |||
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to tumor infiltration | |||
| style="background:#F5F5F5;" align="center" + | + | |||
| style="background:#F5F5F5;" align="center" + | - | |||
| style="background:#F5F5F5;" align="center" + | - | |||
| style="background:#F5F5F5;" align="center" + | - | |||
|}<br /> | |||
==Reference== | |||
{{Reflist|2}} | |||
Latest revision as of 00:22, 20 January 2021
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Joban Ghuman, M.B.B.S.[2]
monoclonal gammopathy of undetermined significance
\Monoclonal gammopathies are conditions in which abnormal proteins (antibodies) are found in the blood. These proteins are produced from a small number of plasma cells in the bone marrow. Plasma cells are a type of white blood cell. Their main job is to make antibodies to fight infection.
| Criteria | Symptomatic WM | Asymptomatic WM | IgM-Related Disorders | MGUS |
|---|---|---|---|---|
| IgM monoclonal protein | + | + | + | + |
| Bone marrow infiltration | + | + | - | - |
| Symptoms attributable to IgM | + | - | + | - |
| Symptoms attributable to tumor infiltration | + | - | - | - |
Reference
- ↑ Mao Y, Yang D, He J, Krasna MJ (2016). "Epidemiology of Lung Cancer". Surg Oncol Clin N Am. 25 (3): 439–45. doi:10.1016/j.soc.2016.02.001. PMID 27261907.