Metabolic acidosis future or investigational therapies: Difference between revisions
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==== <u><big>Experimental Treatment:</big></u> ==== | ====<u><big>Experimental Treatment:</big></u>==== | ||
Small animal studies of various models of shock and lactic acidosis demonstrated improved cardiac function, reduced mortality, and decreased generation of pro-inflammatory cytokines; human studies yet to be performed, so options include as follows: | Small animal studies of various models of [[shock]] and [[lactic acidosis]] demonstrated improved [[cardiac]] function, reduced [[mortality]], and decreased generation of pro-inflammatory [[cytokines]]; human studies yet to be performed, so options include as follows: | ||
# Dichloroacetate | #[[Dichloroacetate]] | ||
# Administration of selective inhibitors Na+-H+ Exchanger 1 or | #Administration of [[selective inhibitors Na+-H+ Exchanger]] 1 or [[amiloride]] analogues | ||
# Administration of inhibitors of transient receptor potential vanilloid 1 | #Administration of inhibitors of transient receptor potential vanilloid 1 | ||
# Administration of selective inhibitors acid sensing Ion channel la | #Administration of selective inhibitors acid sensing [[Ion channels|Ion channel]] la | ||
# Administration of inhibitors of mitogen activated protein kinase | #Administration of inhibitors of [[mitogen]] activated protein [[Protein kinase inhibitor|kinase]] | ||
==References== | ==References== | ||
Latest revision as of 20:09, 19 February 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Experimental Treatment:
Small animal studies of various models of shock and lactic acidosis demonstrated improved cardiac function, reduced mortality, and decreased generation of pro-inflammatory cytokines; human studies yet to be performed, so options include as follows:
- Dichloroacetate
- Administration of selective inhibitors Na+-H+ Exchanger 1 or amiloride analogues
- Administration of inhibitors of transient receptor potential vanilloid 1
- Administration of selective inhibitors acid sensing Ion channel la
- Administration of inhibitors of mitogen activated protein kinase