Metabolic acidosis future or investigational therapies: Difference between revisions
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| [[File:Siren.gif|30px|link=Metabolic acidosis resident survival guide]]|| <br> || <br> | |[[File:Siren.gif|30px|link=Metabolic acidosis resident survival guide]]||<br>||<br> | ||
| [[Metabolic acidosis resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']] | |[[Metabolic acidosis resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']] | ||
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| [[File:Physician_Extender_Algorithms.gif|88px|link=Metabolic acidosis physician extender algorithm]]|| <br> || <br> | |[[File:Physician_Extender_Algorithms.gif|88px|link=Metabolic acidosis physician extender algorithm]]||<br>||<br> | ||
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{{Metabolic acidosis}} | {{Metabolic acidosis}} | ||
{{CMG}} | {{CMG}} | ||
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====<u><big>Experimental Treatment:</big></u>==== | |||
Small animal studies of various models of [[shock]] and [[lactic acidosis]] demonstrated improved [[cardiac]] function, reduced [[mortality]], and decreased generation of pro-inflammatory [[cytokines]]; human studies yet to be performed, so options include as follows: | |||
#[[Dichloroacetate]] | |||
#Administration of [[selective inhibitors Na+-H+ Exchanger]] 1 or [[amiloride]] analogues | |||
#Administration of inhibitors of transient receptor potential vanilloid 1 | |||
#Administration of selective inhibitors acid sensing [[Ion channels|Ion channel]] la | |||
#Administration of inhibitors of [[mitogen]] activated protein [[Protein kinase inhibitor|kinase]] | |||
==References== | ==References== | ||
Latest revision as of 20:09, 19 February 2021
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Resident Survival Guide |
| File:Physician Extender Algorithms.gif |
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Metabolic acidosis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Metabolic acidosis future or investigational therapies On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Experimental Treatment:
Small animal studies of various models of shock and lactic acidosis demonstrated improved cardiac function, reduced mortality, and decreased generation of pro-inflammatory cytokines; human studies yet to be performed, so options include as follows:
- Dichloroacetate
- Administration of selective inhibitors Na+-H+ Exchanger 1 or amiloride analogues
- Administration of inhibitors of transient receptor potential vanilloid 1
- Administration of selective inhibitors acid sensing Ion channel la
- Administration of inhibitors of mitogen activated protein kinase