Sore throat in children: Difference between revisions
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==Historical Perspective== | ==Historical Perspective== | ||
*In the year 1879, R. L. Bowles, M.D., described [[sore throat]] as 'some variants of sore throat' in the British Medical Journal. <ref name="pmid20749164">Bowles RL (1879) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=20749164 Some Varieties of Sore-Throat.] ''Br Med J'' 1 (953):503-4. PMID: [https://pubmed.gov/20749164 20749164]</ref> | |||
*Later, in the year 1885, [[pathology]], clinical findings and management were described by David Newman, M.D., at the Glasgow Royal Infirmary.<ref name="pmid20751315">Newman D (1885) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=20751315 Two Lectures on Chronic Laryngitis and Chronic Pharyngitis: Their [[Pathology]], Symptoms, and Treatment.] ''Br Med J'' 2 (1279):5-7. PMID: [https://pubmed.gov/20751315 20751315]</ref> | |||
*In 1910, the importance of laboratory tests was illustrated by Dr. Donelan.<ref name="pmid19974411">Grant JD (1910) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=19974411 Secondary Specific [[Pharyngitis]] in a Young Woman.] ''Proc R Soc Med'' 3 (Laryngol Sect):28. PMID: [https://pubmed.gov/19974411 19974411]</ref> | |||
* In 1931, WM. W. PRIDDLE, B.A., M.D., described that certain infections like [[whooping cough]], [[measles]] were associated with chronic [[nasopharyngitis]].<ref name="pmid20318472">Priddle WW (1931) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=20318472 CHRONIC NASO-PHARYNGITIS AND CHRONIC BRONCHIAL INFECTION.] ''Can Med Assoc J'' 25 (4):441-3. PMID: [https://pubmed.gov/20318472 20318472]</ref> | |||
==Classification== | ==Classification== | ||
| Line 35: | Line 38: | ||
*[[Prostaglandins]] and [[bradykinin]] act on the sensory nerves in the [[pharynx]], which leads to sore throat. | *[[Prostaglandins]] and [[bradykinin]] act on the sensory nerves in the [[pharynx]], which leads to sore throat. | ||
*Fever is the result of [[cytokine]] release and thought to benefit host's response to infection. Cytokines can also cause headache. | *Fever is the result of [[cytokine]] release and thought to benefit host's response to infection. Cytokines can also cause headache. | ||
*The [[cranial nerves]] that supply the [[nasopharynx]] are responsible for pain perception. | *The [[cranial nerves]] that supply the [[nasopharynx]] are responsible for pain perception. | ||
*Vasodilator mediators like bradykinin causes dilation of the [[venous sinuses]] in the nasal epithelium which is responsible for nasal congestion. | *Vasodilator mediators like bradykinin causes dilation of the [[venous sinuses]] in the nasal epithelium which is responsible for nasal congestion. | ||
*[[Glandular]] secretions with different cells (e.g. [[neutrophils]], [[plasma cells]], [[goblet cells]]) and plasma together in different compositions at different times, form nasal discharge. | *[[Glandular]] secretions with different cells (e.g. [[neutrophils]], [[plasma cells]], [[goblet cells]]) and plasma together in different compositions at different times, form nasal discharge. | ||
*[[Inflammation]] in the [[nasopharynx]], stimulates the [[trigeminal nerves]], which presents in the form of sneezing. | *[[Inflammation]] in the [[nasopharynx]], stimulates the [[trigeminal nerves]], which presents in the form of sneezing. | ||
*The inflammation when reaches the [[larynx]], and stimulates the sensory nerves then coughing is initiated. The inflammatory mediators when act on the sensory nerve endings of the airway cause hyper-reactivity of the [[cough reflex]]. <ref name="urlPathophysiology of Clinical Symptoms in Acute Viral Respiratory Tract Infections | SpringerLink">{{cite web |url=https://link.springer.com/chapter/10.1007/5584_2015_110 |title=Pathophysiology of Clinical Symptoms in Acute Viral Respiratory Tract Infections | SpringerLink |format= |work= |accessdate=}}</ref> | *The inflammation when reaches the [[larynx]], and stimulates the sensory nerves then coughing is initiated. The inflammatory mediators when act on the sensory nerve endings of the airway cause hyper-reactivity of the [[cough reflex]]. <ref name="urlPathophysiology of Clinical Symptoms in Acute Viral Respiratory Tract Infections | SpringerLink">{{cite web |url=https://link.springer.com/chapter/10.1007/5584_2015_110 |title=Pathophysiology of Clinical Symptoms in Acute Viral Respiratory Tract Infections | SpringerLink |format= |work= |accessdate=}}</ref> | ||
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==Differentiating Sore throat in children from other Diseases== | ==Differentiating Sore throat in children from other Diseases== | ||
Sore throat is a symptom and can be seen in many varieties of diseases as an initial complaint of presentation. Clinical history and physical examination can help to distinguish between them. | Sore throat is a symptom and can be seen in many varieties of diseases as an initial complaint of presentation. Clinical history and physical examination can help to distinguish between them.<ref name="urlSore Throat">{{cite web |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152117/ |title=Sore Throat |format= |work= |accessdate=}}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
|+ Differential diagnosis of sore throat | |+Differential diagnosis of sore throat | ||
|- | |- | ||
! Disease !! Clinical presentation !! Physical examination | !Disease!!Clinical presentation!!Physical examination | ||
|- | |- | ||
| Aphthous stomatitis || systemic symptoms absent || anterior oral mucosa ulcers | |Aphthous stomatitis||systemic symptoms absent||anterior oral mucosa ulcers | ||
|- | |- | ||
| Herpangina || high fever, sore throat || multiple, small ulcers in the posterior oropharynx | |Herpangina||high fever, sore throat||multiple, small ulcers in the posterior oropharynx | ||
|- | |- | ||
| Herpetic gingivostomatitis ||fever, pharyngeal erythema, sore throat | |Herpetic gingivostomatitis||fever, pharyngeal erythema, sore throat||multiple, small ulcers around the lips and anterior oral cavity | ||
|- | |- | ||
| Hand-Foot-Mouth disease || fever, malaise, oral pain, sore throat|| ulcers around and inside the mouth, rash on hands, feet and buttocks | |Hand-Foot-Mouth disease||fever, malaise, oral pain, sore throat||ulcers around and inside the mouth, rash on hands, feet and buttocks | ||
|- | |- | ||
|Measles || high grade fevre, cough, conjunctivitis and coryza, pharyngeal erythema || Koplik spots, erythematous rash beginning from face and disseminates to whole body | |Measles||high grade fevre, cough, conjunctivitis and coryza, pharyngeal erythema||Koplik spots, erythematous rash beginning from face and disseminates to whole body | ||
|- | |- | ||
| Infectious Mononucleosis || fever, fatigue, headache, sore throat || tonsilar exudate, cervical lymphadenopathy, hepatosplenomegaly | |Infectious Mononucleosis||fever, fatigue, headache, sore throat||tonsilar exudate, cervical lymphadenopathy, hepatosplenomegaly | ||
|- | |- | ||
| Primary HIV infection || fever, sore throat || lymphadenopathy, rash, enlarged spleen | |Primary HIV infection||fever, sore throat||lymphadenopathy, rash, enlarged spleen | ||
|- | |- | ||
|Group A Streptococcus || fever, headache, malaise, sore throat || erythematous pharynx, anterior cervical lymphadenopathy | |Group A Streptococcus||fever, headache, malaise, sore throat||erythematous pharynx, anterior cervical lymphadenopathy | ||
|- | |- | ||
| Cornybacterium diphtheriae || fever, malaise, sore throat || grayish-white pseudomembrane in the pharynx which cannot be scraped off, cervical lymphadenopathy | |Cornybacterium diphtheriae||fever, malaise, sore throat||grayish-white pseudomembrane in the pharynx which cannot be scraped off, cervical lymphadenopathy | ||
|- | |- | ||
|Oral thrush || | |Oral thrush||sore throat, cotton like feeling in mouth, cracked lips, loss of taste||erythematous pharynx, cotton-cheese like lesions which can be easily scraped off with slight bleeding | ||
|- | |- | ||
|} | |} | ||
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==Natural History, Complications and Prognosis== | ==Natural History, Complications and Prognosis== | ||
*The majority of patients with Sore throat acquire it as a course of the respiratory tract or oropharyngeal infections remain asymptomatic for | *The majority of patients with Sore throat acquire it as a course of the respiratory tract or [[oropharyngeal]] infections and remain [[asymptomatic]] for 1-4 days.<ref name="pmid14604932">{{cite journal |vauthors=Butler CC, Kinnersley P, Hood K, Robling M, Prout H, Rollnick S, Houston H |title=Clinical course of acute infection of the upper respiratory tract in children: cohort study |journal=BMJ |volume=327 |issue=7423 |pages=1088–9 |date=November 2003 |pmid=14604932 |pmc=261746 |doi=10.1136/bmj.327.7423.1088 |url=}}</ref> | ||
*Early clinical features include pain in the throat, itching, discomfort while more severe forms include difficulty swallowing, difficulty breathing. | *Early clinical features include pain in the throat, itching, discomfort while more severe forms include difficulty swallowing, difficulty breathing. | ||
*These symptoms are usually accompanied by fever, myalgias, arthralgias, cough depending on the type of infection. | *These symptoms are usually accompanied by fever, [[myalgias]], [[arthralgias]], [[rhinorrhea]], cough depending on the type of infection. | ||
*Common complications if left untreated in infectious conditions include [[Retropharyngeal abscess]], [[Parapharyngeal abscess]], [[Quinsy]], [[Sepsis]]. | *Common complications if left untreated in infectious conditions include sinusitis, [[mastoiditis]], otitis media, cervical lymphadenitis, [[Retropharyngeal abscess]], [[Parapharyngeal abscess]], [[Quinsy]], [[Sepsis]].<ref name="urlSore Throat">{{cite web |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152117/ |title=Sore Throat |format= |work= |accessdate=}}</ref> | ||
*Prognosis is generally excellent and when identified early in acute conditions, minimal to no complications occur. However sore throat is one of the most common complaints and can be relieved by symptomatic treatment if viral. | *The nonsuppurative complications include include acute [[glomerulonephritis]], [[acute rheumatic fever]], reactive arthritis. | ||
*Prognosis is generally excellent and when identified early in acute conditions, minimal to no complications occur. However sore throat is one of the most common complaints and can be relieved by symptomatic treatment if viral. Most of the patients improve spontaneously within 7-10 days.<ref name="urlPharyngitis - StatPearls - NCBI Bookshelf">{{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK519550/ |title=Pharyngitis - StatPearls - NCBI Bookshelf |format= |work= |accessdate=}}</ref> | |||
==Diagnosis== | ==Diagnosis== | ||
===Diagnostic Criteria=== | ===Diagnostic Criteria=== | ||
The four important diagnostic criteria for sore throat are <ref name="pmid18000276">{{cite journal |vauthors=Worrall GJ |title=Acute sore throat |journal=Can Fam Physician |volume=53 |issue=11 |pages=1961–2 |date=November 2007 |pmid=18000276 |pmc=2231494 |doi= |url=}}</ref> | The four important diagnostic criteria, also known as [[Centor criteria]] for sore throat are <ref name="pmid18000276">{{cite journal |vauthors=Worrall GJ |title=Acute sore throat |journal=Can Fam Physician |volume=53 |issue=11 |pages=1961–2 |date=November 2007 |pmid=18000276 |pmc=2231494 |doi= |url=}}</ref> | ||
:*Absent cough and runny nose | :*Absent cough and runny nose | ||
| Line 122: | Line 126: | ||
:*Anterior cervical lymphadenopathy | :*Anterior cervical lymphadenopathy | ||
All 4 criteria present GABHS most likely | All 4 criteria present GABHS most likely, no testing required, start empiric antibiotics. | ||
2 or 3 | 2 or 3- further testing required | ||
0 or 1- | 0 or 1- further testing or antibiotics not required | ||
:* | :* | ||
| Line 144: | Line 148: | ||
*Patients with Sore throat usually appear normal in common infections. | *Patients with Sore throat usually appear normal in common infections. | ||
*Physical examination may be different depending on the underlying etiology as well as pathology. Examination of the [[pharynx]] is the key. However comprehensive examination gives hints for possible etiologies. Notable findings include:<ref name="urlSore Throat in Children – Clinical Considerations and Evaluation | Learn Pediatrics">{{cite web |url=https://learn.pediatrics.ubc.ca/body-systems/general-pediatrics/sore-throat-in-children-clinical-considerations-and-evaluation/ |title=Sore Throat in Children – Clinical Considerations and Evaluation | Learn Pediatrics |format= |work= |accessdate=}}</ref> | |||
*Physical examination may be different depending on the underlying etiology as well as pathology. Examination of the [[pharynx]] is the key. However comprehensive examination gives hints for possible etiologies. Notable findings include: | |||
:*[[Exudative]] [[Pharyngitis]], [[petechiae]] on the posterior [[palate]], anterior [[Cervical lymphadenopathy]] are seen in [[streptococcal pharyngitis]]. | :*[[Exudative]] [[Pharyngitis]], [[petechiae]] on the posterior [[palate]], anterior [[Cervical lymphadenopathy]] are seen in [[streptococcal pharyngitis]]. | ||
| Line 162: | Line 163: | ||
===Laboratory Findings=== | ===Laboratory Findings=== | ||
There is an overlap of clinical findings between various types of sore throat and to narrow down the diagnosis we use some laboratory tests and imaging studies | There is an overlap of clinical findings between various types of sore throat and to narrow down the diagnosis, we use some laboratory tests and imaging studies.<ref name="urlStreptococcal Pharyngitis - StatPearls - NCBI Bookshelf">{{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK525997/ |title=Streptococcal Pharyngitis - StatPearls - NCBI Bookshelf |format= |work= |accessdate=}}</ref> | ||
*A | *Rapid Antigen Detection Test(RADT)- It is first line diagnostic test for Group A Streptococcal (GAS) pharyngitis. A positive test is diagnostic of GAS infection and antibiotics should be started. If the test comes out to be negative, then a follow-up throat culture should be done. | ||
* | *[[Throat culture]]-(90-99 % sensitive) - Though its best test, but takes time for the result. Used in non-emergency situations and when the RADT is negative. If positive, antibiotics are started, if negative, symptomatic management is given. | ||
* | *[[Antistreptococcal antibodies]] are useful for the confirmation of previous GAS infection in case of acute rheumatic fever or other nonsuppurative complications.<ref name="urlPharyngitis">{{cite web |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152356/ |title=Pharyngitis |format= |work= |accessdate=}}</ref> | ||
*Monospot test- Used for the diagnosis of Infectious Mononucleosis due to Epstein-Barr virus. | |||
*[[Peripheral blood smear]] shows [[atypical lymphocytes]] in [[Infectious Mononucleosis]]. | |||
*[[Complete blood count]] (CBC), [[ESR]] and [[CRP]] are usually not used due to low predictive value | |||
===Imaging Studies=== | ===Imaging Studies=== | ||
Imaging studies are usually not used for uncomplicated sore throat and reserved for complicated cases only | Imaging studies are usually not used for uncomplicated sore throat and reserved for complicated cases only.<ref name="urlPharyngitis Workup: Laboratory Studies, Imaging Studies, Procedures">{{cite web |url=https://emedicine.medscape.com/article/764304-workup#c6 |title=Pharyngitis Workup: Laboratory Studies, Imaging Studies, Procedures |format= |work= |accessdate=}}</ref> | ||
*[[X-Ray]] of neck, lateral view for suspected [[epiglottitis]] and airway compromise. Epiglottitis appears as thumb print sign in the x-ray. | |||
*[[CT scan]] neck, there are no CT scan findings associated with sore throat. However, a CT scan may be helpful in the diagnosis of complications of sore throat, which include [[retropharyngeal abscess]], [[peritonsillar abscess]] and suppurative cervical lymphadenitis. | |||
[ | |||
==Treatment== | ==Treatment== | ||
| Line 230: | Line 182: | ||
===Medical Therapy=== | ===Medical Therapy=== | ||
*Treatment for sore throat in most children is supportive care and systemic [[analgesia]]. [[Acetaminophen]], [[NSAIDS]] Non Steroidal anti inflammatory drugs and steam inhalation help alleviate the [[pain]]. | *Treatment for sore throat in most children is supportive care and systemic [[analgesia]]. [[Acetaminophen]], [[NSAIDS]] Non Steroidal anti inflammatory drugs and steam inhalation help alleviate the [[pain]]. | ||
*[[Corticosteroids]] are considered if pain is unresponsive to simple analgesics. | *[[Corticosteroids]] are considered if pain is unresponsive to simple analgesics. | ||
*They do not need [[antibiotics]]. Antibiotics are reserved for children in the high risk group ( immunosuppressed children, family or personal history of [[rheumatic heart disease]] or [[rheumatic fever]]) to prevent complications due to infection. | *They do not need [[antibiotics]]. Antibiotics are reserved for children in the high risk group ( immunosuppressed children, family or personal history of [[rheumatic heart disease]] or [[rheumatic fever]]) to prevent complications due to infection. | ||
*The antibiotic of choice is [[Penicillin]]. [[Amoxicillin]], [[Erythromycin]] or [[Azithromycin]] (for penicillin [[hypersensitivity]]) and first generation [[cephalosporins]] ( [[anaphylaxis]] to beta-lactams) are used as alternatives.<ref name="urlClinical Practice Guidelines : Sore throat">{{cite web |url=https://www.rch.org.au/clinicalguide/guideline_index/Sore_throat/#high-risk |title=Clinical Practice Guidelines : Sore throat |format= |work= |accessdate=}}</ref> | *The antibiotic of choice is [[Penicillin]]. [[Amoxicillin]], [[Erythromycin]] or [[Azithromycin]] (for penicillin [[hypersensitivity]]) and first generation [[cephalosporins]] ( [[anaphylaxis]] to beta-lactams) are used as alternatives.<ref name="urlClinical Practice Guidelines : Sore throat">{{cite web |url=https://www.rch.org.au/clinicalguide/guideline_index/Sore_throat/#high-risk |title=Clinical Practice Guidelines : Sore throat |format= |work= |accessdate=}}</ref> | ||
===Surgery=== | ===Surgery=== | ||
Surgical procedures are used in some specific conditions in children <ref name="pmid25587367">{{cite journal |vauthors=Stelter K |title=Tonsillitis and sore throat in children |journal=GMS Curr Top Otorhinolaryngol Head Neck Surg |volume=13 |issue= |pages=Doc07 |date=2014 |pmid=25587367 |pmc=4273168 |doi=10.3205/cto000110 |url=}}</ref> | |||
*Complete [[tonsillectomy]] is the mainstay of therapy for recurrent tonsillitis, if the episodes are | |||
**equal to or greater than 7 in a year. | |||
**equal to or greater than 5/year in 2 consecutive years. | |||
**equal to or greater than 3/year in 3 consecutive years. | |||
*Partial tonsillectomy is the preferred procedure for tonsillar [[hyperplasia]] with ronchopathia. | |||
*[[Aspiration]] or tonsillectomy punction is used for draining tonsillar [[abscess]]. | |||
===Prevention=== | ===Prevention=== | ||
| Line 259: | Line 213: | ||
===Follow up=== | ===Follow up=== | ||
A follow-up is required if <ref name="urlwww.med.umich.edu">{{cite web |url=http://www.med.umich.edu/1info/FHP/practiceguides/pharyngitis/pharyn.pdf |title=www.med.umich.edu |format= |work= |accessdate=}}</ref> | |||
:*fever and throat pain lasts for more than 48hours after starting treatment | |||
:*[[dysphagia]] | |||
:*new symptoms | |||
==References== | ==References== | ||
Latest revision as of 17:03, 12 May 2021
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sunita Kumawat, M.B.B.S[2]
Synonyms and keywords: Sore throat in kids
Overview
Sore throat is an infection of the respiratory mucosa of the throat.It is most commonly felt as a sensation of pain in the pharynx. In children it can be classified as acute, subacute or recurrent. Common etiologies include bacterial, Viral and Protozoal organisms. It is usually self resolving, but can be associated with more severe disease forms. Treatment in general is conservative, however Antibiotics and Antivirals can be used depending on the Etiology, and severity of clinical presentation.
Historical Perspective
- In the year 1879, R. L. Bowles, M.D., described sore throat as 'some variants of sore throat' in the British Medical Journal. [1]
- Later, in the year 1885, pathology, clinical findings and management were described by David Newman, M.D., at the Glasgow Royal Infirmary.[2]
- In 1910, the importance of laboratory tests was illustrated by Dr. Donelan.[3]
- In 1931, WM. W. PRIDDLE, B.A., M.D., described that certain infections like whooping cough, measles were associated with chronic nasopharyngitis.[4]
Classification
- Sore throat can be classified into Infectious and Non infectious causes based on the etiology.[5]
Infectious
- Bacterial:Group A Streptococci,Staphylococcus aureus, Hemophilus influenza, gonococci, chlamydia, Mycoplasma, Treponema pallidum, Fusobacterium.
- Viral: Adenovirus, Coxsackievirus, Enterovirus, Influenza, Parainfluenza, Epstein Barr Virus, Corona Viruses, Polio Virus, Rhino Virus.
- Protozoal: Babesia microti, Toxoplasma gondii,- less common causes.
- Fungal: Candida.
Non Infectious
- Autoimmune: Steven Johnson's syndrome, Bechet's disease, Psychotic, Kawasaki's disease, PFAPA syndrome.
- Traumatic: Insertion of a pen, stick, or other sharp object in the throat.
- Chemical exposure : smoking, air pollutants
- Physical factors : snoring, shouting, tracheal intubation
Pathophysiology
- Prostaglandins and bradykinin act on the sensory nerves in the pharynx, which leads to sore throat.
- Fever is the result of cytokine release and thought to benefit host's response to infection. Cytokines can also cause headache.
- The cranial nerves that supply the nasopharynx are responsible for pain perception.
- Vasodilator mediators like bradykinin causes dilation of the venous sinuses in the nasal epithelium which is responsible for nasal congestion.
- Glandular secretions with different cells (e.g. neutrophils, plasma cells, goblet cells) and plasma together in different compositions at different times, form nasal discharge.
- Inflammation in the nasopharynx, stimulates the trigeminal nerves, which presents in the form of sneezing.
- The inflammation when reaches the larynx, and stimulates the sensory nerves then coughing is initiated. The inflammatory mediators when act on the sensory nerve endings of the airway cause hyper-reactivity of the cough reflex. [6]
Causes
Sore throat in children can be acutely life-threatening or from common causes.[7]
Bacteria
- Goup A beta-haemolytic Streptococcus (most commonly isolated)
- Haemophilus influenzae
- Moraxella catarrhalis
Viruses
- Life threatening causes include: Epiglottitis,retropharygeal abscess, Parapharyngeal abscess, Peritonsillar abscess, Diptheria, Infectious mononucleosis
- other causes include: trauma,psychogenic and autoimmune
Differentiating Sore throat in children from other Diseases
Sore throat is a symptom and can be seen in many varieties of diseases as an initial complaint of presentation. Clinical history and physical examination can help to distinguish between them.[8]
| Disease | Clinical presentation | Physical examination |
|---|---|---|
| Aphthous stomatitis | systemic symptoms absent | anterior oral mucosa ulcers |
| Herpangina | high fever, sore throat | multiple, small ulcers in the posterior oropharynx |
| Herpetic gingivostomatitis | fever, pharyngeal erythema, sore throat | multiple, small ulcers around the lips and anterior oral cavity |
| Hand-Foot-Mouth disease | fever, malaise, oral pain, sore throat | ulcers around and inside the mouth, rash on hands, feet and buttocks |
| Measles | high grade fevre, cough, conjunctivitis and coryza, pharyngeal erythema | Koplik spots, erythematous rash beginning from face and disseminates to whole body |
| Infectious Mononucleosis | fever, fatigue, headache, sore throat | tonsilar exudate, cervical lymphadenopathy, hepatosplenomegaly |
| Primary HIV infection | fever, sore throat | lymphadenopathy, rash, enlarged spleen |
| Group A Streptococcus | fever, headache, malaise, sore throat | erythematous pharynx, anterior cervical lymphadenopathy |
| Cornybacterium diphtheriae | fever, malaise, sore throat | grayish-white pseudomembrane in the pharynx which cannot be scraped off, cervical lymphadenopathy |
| Oral thrush | sore throat, cotton like feeling in mouth, cracked lips, loss of taste | erythematous pharynx, cotton-cheese like lesions which can be easily scraped off with slight bleeding |
Epidemiology and Demographics
One of the most common medical conditions is sore throat, primarily caused by viruses and bacteria. Group A streptococcus(GAS) is the most common causative agent, resposible for 15-25% of cases of pharyngitis in children and 10% in adults. Diagnosis of GAS is important for the treatment and reduction of infectivity. It also prevents post infectious complications. The acute suppurative complications are retropharyngeal and peritonsillar abscess, acute bacterial sinusitis, cervical adenitis and acute otitis media. The late nonsuppurative complications are acute rheumatic fever (ARF) and post-streptococcal glomerulonephritis. In adults, nonsuppurative complications does not need immediate treatment.[9]
Risk Factors
- The factors which make an individual more susceptible to sore throat are lack of Vaccination, weakened immunity, frequent or chronic sinus infections, age, allergies, chemical irritants or tobacco smoke exposure, close spaces.[10]
Natural History, Complications and Prognosis
- The majority of patients with Sore throat acquire it as a course of the respiratory tract or oropharyngeal infections and remain asymptomatic for 1-4 days.[11]
- Early clinical features include pain in the throat, itching, discomfort while more severe forms include difficulty swallowing, difficulty breathing.
- These symptoms are usually accompanied by fever, myalgias, arthralgias, rhinorrhea, cough depending on the type of infection.
- Common complications if left untreated in infectious conditions include sinusitis, mastoiditis, otitis media, cervical lymphadenitis, Retropharyngeal abscess, Parapharyngeal abscess, Quinsy, Sepsis.[8]
- The nonsuppurative complications include include acute glomerulonephritis, acute rheumatic fever, reactive arthritis.
- Prognosis is generally excellent and when identified early in acute conditions, minimal to no complications occur. However sore throat is one of the most common complaints and can be relieved by symptomatic treatment if viral. Most of the patients improve spontaneously within 7-10 days.[12]
Diagnosis
Diagnostic Criteria
The four important diagnostic criteria, also known as Centor criteria for sore throat are [13]
- Absent cough and runny nose
- Fever >38 C (100.4 F)
- Tonsillar exudate
- Anterior cervical lymphadenopathy
All 4 criteria present GABHS most likely, no testing required, start empiric antibiotics.
2 or 3- further testing required
0 or 1- further testing or antibiotics not required
Symptoms
- Sudden onset of sore throat and fever.
- Other symptoms may include:
- Nausea and vomiting, headache, malaise, discomfort in swallowing and abdominal pain.
- Cough, conjunctivitis, nasal congestion and rhinorrhoea are present in viral etiology
- Redness and swelling of tonsils and pharynx are present.
- Tender and enlarged anterior cervical lymph nodes.
- Pharyngeal exudate that can be easily scraped off is present.
Physical Examination
- Patients with Sore throat usually appear normal in common infections.
- Physical examination may be different depending on the underlying etiology as well as pathology. Examination of the pharynx is the key. However comprehensive examination gives hints for possible etiologies. Notable findings include:[14]
- Exudative Pharyngitis, petechiae on the posterior palate, anterior Cervical lymphadenopathy are seen in streptococcal pharyngitis.
- Thick white exudate with a membranous covering of tonsils, which cannot be removed without bleeding is seen in Diptheria.
- Erythematous Pharynx with posterior cervical lymphadenopathy and hepatosplenomegaly is seen in infectious mononucleosis.
- Vesicular rash on the posterior pharynx is seen in herpangia, and vesicular rash on hand foot, and mouth is seen in hand, foot, and mouth disease. Both are caused by Coxsackie Virus.
- Erythematous pharynx with a diffuse erythematous rash is seen in Scarlet fever.
- Stridor, respiratory distress, dysphagia, odynophagia with high grade fevers can be seen in Quinsy, retropharyngeal abscess, Parapharyngeal abscess, epiglottitis, Laryngotracheobronchitis. Most of these are life threatening. Significant asymmetry of the tonsils should raise suspicion for peritonsillar abscess.
- Vesicles on the buccal mucosa should raise suspicion for Herpetic Gingivostomatitis. Patients should also be screened for non-infectious causes such as bechet syndrome,Steven Johnson syndrome.
- Inflammed tympanic membrane might suggest a dental abscess. Other possible oropharyngeal pathologies should be ruled out.
- Pernio like lesions in the pharynx is seen in COVID 19 infection.
- If a persistently febrile child demonstrates strawberry tongue, generalized erythema of oropharynx, cracked red lips, cervical lymphadenopathy, non purulent conjunctivitis, along with desquamation of periungual region and swelling of hands and foot and then suspect kawasaki disease.
Laboratory Findings
There is an overlap of clinical findings between various types of sore throat and to narrow down the diagnosis, we use some laboratory tests and imaging studies.[15]
- Rapid Antigen Detection Test(RADT)- It is first line diagnostic test for Group A Streptococcal (GAS) pharyngitis. A positive test is diagnostic of GAS infection and antibiotics should be started. If the test comes out to be negative, then a follow-up throat culture should be done.
- Throat culture-(90-99 % sensitive) - Though its best test, but takes time for the result. Used in non-emergency situations and when the RADT is negative. If positive, antibiotics are started, if negative, symptomatic management is given.
- Antistreptococcal antibodies are useful for the confirmation of previous GAS infection in case of acute rheumatic fever or other nonsuppurative complications.[16]
- Monospot test- Used for the diagnosis of Infectious Mononucleosis due to Epstein-Barr virus.
- Peripheral blood smear shows atypical lymphocytes in Infectious Mononucleosis.
- Complete blood count (CBC), ESR and CRP are usually not used due to low predictive value
Imaging Studies
Imaging studies are usually not used for uncomplicated sore throat and reserved for complicated cases only.[17]
- X-Ray of neck, lateral view for suspected epiglottitis and airway compromise. Epiglottitis appears as thumb print sign in the x-ray.
- CT scan neck, there are no CT scan findings associated with sore throat. However, a CT scan may be helpful in the diagnosis of complications of sore throat, which include retropharyngeal abscess, peritonsillar abscess and suppurative cervical lymphadenitis.
Treatment
Medical Therapy
- Treatment for sore throat in most children is supportive care and systemic analgesia. Acetaminophen, NSAIDS Non Steroidal anti inflammatory drugs and steam inhalation help alleviate the pain.
- Corticosteroids are considered if pain is unresponsive to simple analgesics.
- They do not need antibiotics. Antibiotics are reserved for children in the high risk group ( immunosuppressed children, family or personal history of rheumatic heart disease or rheumatic fever) to prevent complications due to infection.
- The antibiotic of choice is Penicillin. Amoxicillin, Erythromycin or Azithromycin (for penicillin hypersensitivity) and first generation cephalosporins ( anaphylaxis to beta-lactams) are used as alternatives.[18]
Surgery
Surgical procedures are used in some specific conditions in children [19]
- Complete tonsillectomy is the mainstay of therapy for recurrent tonsillitis, if the episodes are
- equal to or greater than 7 in a year.
- equal to or greater than 5/year in 2 consecutive years.
- equal to or greater than 3/year in 3 consecutive years.
- Partial tonsillectomy is the preferred procedure for tonsillar hyperplasia with ronchopathia.
- Aspiration or tonsillectomy punction is used for draining tonsillar abscess.
Prevention
Certain measures for the primary prevention of sore throat are [20]
- Regular hand-washing.
- Keep the eating utensils of the infected person separately and wash them thoroughly.
- Toys of an infected toddler should be cleaned properly.
- Try to dispose of any dirty tissues and wipes , and wash your hands.
- A child with strep throat infection should not return to school until she or he finishes a 24 hour course of antibiotics with symptom improvement.
Follow up
A follow-up is required if [21]
- fever and throat pain lasts for more than 48hours after starting treatment
- dysphagia
- new symptoms
References
- ↑ Bowles RL (1879) Some Varieties of Sore-Throat. Br Med J 1 (953):503-4. PMID: 20749164
- ↑ Newman D (1885) Two Lectures on Chronic Laryngitis and Chronic Pharyngitis: Their Pathology, Symptoms, and Treatment. Br Med J 2 (1279):5-7. PMID: 20751315
- ↑ Grant JD (1910) Secondary Specific Pharyngitis in a Young Woman. Proc R Soc Med 3 (Laryngol Sect):28. PMID: 19974411
- ↑ Priddle WW (1931) CHRONIC NASO-PHARYNGITIS AND CHRONIC BRONCHIAL INFECTION. Can Med Assoc J 25 (4):441-3. PMID: 20318472
- ↑ "Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat) | SpringerLink".
- ↑ "Pathophysiology of Clinical Symptoms in Acute Viral Respiratory Tract Infections | SpringerLink".
- ↑ Kenealy T (March 2014). "Sore throat". BMJ Clin Evid. 2014. PMC 3948435. PMID 24589314.
- ↑ 8.0 8.1 "Sore Throat".
- ↑ "Sore Throat (Pharyngitis) - Infectious Disease and Antimicrobial Agents".
- ↑ "Sore throat - Symptoms and causes - Mayo Clinic".
- ↑ Butler CC, Kinnersley P, Hood K, Robling M, Prout H, Rollnick S, Houston H (November 2003). "Clinical course of acute infection of the upper respiratory tract in children: cohort study". BMJ. 327 (7423): 1088–9. doi:10.1136/bmj.327.7423.1088. PMC 261746. PMID 14604932.
- ↑ "Pharyngitis - StatPearls - NCBI Bookshelf".
- ↑ Worrall GJ (November 2007). "Acute sore throat". Can Fam Physician. 53 (11): 1961–2. PMC 2231494. PMID 18000276.
- ↑ "Sore Throat in Children – Clinical Considerations and Evaluation | Learn Pediatrics".
- ↑ "Streptococcal Pharyngitis - StatPearls - NCBI Bookshelf".
- ↑ "Pharyngitis".
- ↑ "Pharyngitis Workup: Laboratory Studies, Imaging Studies, Procedures".
- ↑ "Clinical Practice Guidelines : Sore throat".
- ↑ Stelter K (2014). "Tonsillitis and sore throat in children". GMS Curr Top Otorhinolaryngol Head Neck Surg. 13: Doc07. doi:10.3205/cto000110. PMC 4273168. PMID 25587367.
- ↑ "Sore Throat (Pharyngitis) - Harvard Health".
- ↑ "www.med.umich.edu" (PDF).