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{| class="wikitable"
|+ Caption text
|-
! Header text !! Header text !! Header text
|-
| Example || Example || Example
|-
| Example || Example || Example
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| Example || Example || Example
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[[User:Dina|Dina Elantably, MD, MSc]][mailto:dina.antably@gmail.com]<br />
[[User:Dina|Dina Elantably, MD, MSc]][mailto:dina.antably@gmail.com]<br />


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* VSD
* VSD


AF
 
 
AF <ref>Jennette JC, Falk RJ, Bacon PA et al (2013) 2012 Revised international Chapel Hill consensus conference nomenclature of vasculitides. Arthritis Rheum 65:1–11. https://doi.org/10.1002/art.37715</ref>
 


Atrial fibrillation
Atrial fibrillation
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{| class="wikitable sortable"
{| class="wikitable"
|+ The 2012 Chapel Hill Consensus Conference (CHCC) classified the vasculitides as follows:
|+ The 2012 Chapel Hill Consensus Conference (CHCC) classified the vasculitides as follows:
|-
|-
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| Kawasaki disease
| Kawasaki disease
|-
|-
| Example
! Small vessel vasculitis
|-
|-
| Example
| ANCA-associated vasculitis: Microscopic polyangiitis, Granulomatosis with polyangiitis (Wegener's), and Eosinophilic granulomatosis with polyangiitis (Churg-Strauss).
|-
|-
| Example
| Immune complex small-vessel vasculitis: Anti-glomerular basement membrane disease, Cryoglobulinemic vasculitis, IgA vasculitis (Henoch-Schönlein), and Hypocomplementemic urticarial vasculitis (anti-C1q vasculitis)
|-
|-
| Example
! Variable-vessel vasculitis
|-
|-
| Example
| Behçet's syndrome
|-
|-
| Example
| Cogan's syndrome
|-
|-
| Example
! Single-organ vasculitis
|-
|-
| Example
| Cutaneous leukocytoclastic angiitis
|-
|-
| Example
| Cutaneous arteritis
|-
|-
| Example
| Primary central nervous system vasculitis
|-
|-
| Example
| Isolated aortitis
|-
|-
| Example
! Vasculitis associated with systemic disease
|-
|-
| Example
| Lupus vasculitis
|-
|-
| Example
| Rheumatoid vasculitis
|-
|-
| Example
| Sarcoid vasculitis
|-
|-
| Example
| Others
|-
|-
| Example
! Vasculitis associated with probable etiology
|-
|-
| Example
| Hepatitis C virus-associated cryoglobulinemic vasculitis
|-
|-
| Example
| Hepatitis B virus-associated vasculitis
|-
|-
| Example
| Syphilis-associated aortitis
|-
|-
| Example
| Drug-associated immune complex vasculitis
|-
|-
| Example
| Drug-associated ANCA-associated vasculitis
|-
|-
| Example
| Cancer-associated vasculitis
|-
|-
| Example
| other
|-
 
| Example
|}
|-
Diagnosis of PSV is based on a combination of clinical, laboratory, histopathological and radiological features
| Example
{{familytree/start |summary=PE diagnosis Algorithm.}}
|-
{{familytree | | | | A01 | | | A01= History suggestive of vasculitis}}
| Example
{{familytree | | | | |!| | | | }}
|-
{{familytree | | |  | B01 | | | B01= Clinical Findings}}
| Example
{{familytree | |,|-|-|-|v|-|-|-|+|-|-|-|v|-|-|-|.| | }}
|-
{{familytree | | C01 | | C02 | C01= Laboratory tests C02= Additional tests }}
| Example
{{familytree | | |,|-|^|-|.| | }}
|-
{{familytree/end}}
| Example
 
|-
 
| Example
 
|-
{{familytree/start |summary=PE diagnosis Algorithm.}}
| Example
{{familytree | | | | | | | | A01 |A01= Induction of Remission }}
|-
{{familytree | | | | |,|-|-|-|^|-|-|-|-|.| | | }}
| Example
{{familytree | | | B01 | | | | | | | | B02 | | | | | | | | B03 | | | | | | | | | B04 |B01= Cyclophosphamide + Glucocorticoid |B02= OR Rituximab + Glucocorticoid |B03= No organ threatening involved: Mycophenolate Mofetyl or Methotrexate |B04= Vital organ/life threatening/creatinine>500 mmol/L : Add Plasma exchange}}
|-
{{familytree | | | |!| | | | | | | | | |!| }}
| Example
{{familytree | | | C01 | | | | | | | | |!| |C01= Disease control on Drug "Remission" }}
|-
{{familytree | |,|-|^|.| | | | | | | | |!| }}
| Example
{{familytree | D01 | | D02 | | | | | | D03 |D01= Switch to Azathioprine or MTX & Taper Glucocorticoid|D02= |D03= Disease control on Drug "Remission" }}
|-
{{familytree | |!| | | | | | | | | |,|-|^|.| }}
| Example
{{familytree | E01 | | | | | | | E02 | | | E03 |E01= continue RTX & Taper Glucocorticoid |E02=  |E03= }}
|-
{{familytree | | | | | | | | | | |!| | | | |!| }}
| Example
{{familytree | | | | | | | | | | F01 | | | F02 |F01= |F02= }}
{{familytree/end}}
 
Labs:
To exclude vasculitis “mimics” and secondary causes
Blood cultures
 
Echocardiogram
 
Hepatitis screen (B and C)
 
HIV test
 
Antiglomerular basement membrane antibody
 
Antiphospholipid antibodies
 
Antinuclear antibody
 
To assess extent of vasculitis
Urine dipstick and microscopy (all patients)
 
Chest radiography (all patients)
 
Nerve conduction studies/electromyography/CK
 
To confirm diagnosis of vasculitis
Biopsy and/or angiogram
 
To identify the specific type of vasculitis
ANCA
 
Cryoglobulin
 
Complement levels
 
Eosinophil counts/IgE levels
 
Specific findings on biopsy (necrotising granulomatous inflammation, presence of IgA deposits, evidence of immune complex formation (or its absence))
<ref>Suresh E. (2006). Diagnostic approach to patients with suspected vasculitis. Postgraduate medical journal, 82(970), 483–488. https://doi.org/10.1136/pgmj.2005.042648</ref>
 
Algorithm of small vs vasculitis dx:
Bezerra, A. S., Polimanti, A. C., Fürst, R., & Corrêa, J. A. (2019). Algorithm for diagnosis of primary vasculitides. Jornal vascular brasileiro, 18, e20180092. https://doi.org/10.1590/1677-5449.009218
 
Algorithm for ttt of AAV:
BSR and BHPR guideline for the management of adults with ANCA-associated vasculitis
December 2014Rheumatology 53(12):2306-9
DOI:10.1093/rheumatology/ket445.
 
 
 
{{familytree/start}}
{{familytree | | | | | | | | | A01 | | | | | |A01=A01}}
{{familytree | | | | | | | | | |!| | | | | | | | }}
{{familytree | | | | | | | | | B01 | | | | | |B01=B01}}
{{familytree | | | | | | | | | |!| | | | | | | | }}
{{familytree | |,|-|-|-|v|-|-|-|+|-|-|-|.| | }}
{{familytree | |!| | | |!| | | |!| | | |!| | }}
{{familytree | C01 | | C02 | | C03 | | C04 | |C01=C01|C02=C02|C03=C03|C04=C04}}
{{familytree/end}}
 
 
{{familytree/start}}
{{familytree | | | | | | | | | A01 | | | | | |A01=A01}}
{{familytree | |,|-|-|-|v|-|-|-|+|-|-|-|.| | }}
{{familytree | |!| | | |!| | | |!| | | |!| | }}
{{familytree | B01 | | B02 | | B03 | | B04 | |B01=B01|B02=B02|B03=B03|B04=B04}}
{{Family tree| |!| | | |!| | | | }}
{{Family tree| C01 | | C02 | | |C01=C01|C02=C02}}
{{Family tree| |:| | | |:| | | | }}
{{Family tree| D01 | | D02 | | |D01=D01|D02=D02}}
{{Family tree| |:| | | |:| | | | }}
{{Family tree| E01 | | E02 | | |E01=E01|E02=E02}}
{{familytree/end}}
 
{| class="infobox" style="float:right;"
|-
|-
| Example
| [[File:Siren.gif|30px|link=Vasculitis resident survival guide]]|| <br> || <br>
| [[Vasculitis resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']]
|}
|}

Latest revision as of 15:20, 21 May 2021

Caption text
Header text Header text Header text
Example Example Example
Example Example Example
Example Example Example

Dina Elantably, MD, MSc[1]


Huda A. Karman, M.D.

Dina Elantably, MD, MSc[2]



AF [2]


Atrial fibrillation

Insulin

Functions

  1. Bind insulin receptors
    1. inducing glucose uptake into insulin dependent tissue
    2. gene transcription
glucose is the major regulator of insulin release to incretins.

Diabetes mellitus It could be due to genetic , enviromental or immune defects.

Regulation of insulin

“ glucose is the main substrate for the brain ”


Thyroid disorders
Findings hypothyroidism Hyperthyroidism


proinsulin and c-peptide

Complications of diabetes:

  1. Major complications
  2. Minor complications
  3. Emergency situations

11 β- hydroxylase deficiency

21 α-hydroxylase deficiency

  1. redirectDiabetes Mellitus


The pathogenesis of chronic recalcitrant hand eczema and its dramatic response to alitretinoin is not yet known. [3]

References

  1. ↑ Spicer DE, Hsu HH, Co-Vu J, Anderson RH, Fricker FJ (2014). "Ventricular septal defect". Orphanet J Rare Dis. 9: 144. doi:10.1186/s13023-014-0144-2. PMC 4316658. PMID 25523232.
  2. ↑ Jennette JC, Falk RJ, Bacon PA et al (2013) 2012 Revised international Chapel Hill consensus conference nomenclature of vasculitides. Arthritis Rheum 65:1–11. https://doi.org/10.1002/art.37715
  3. ↑ Nada, Hanan Rabea; Rashed, Laila Ahmed; Elantably, Dina Mahmoud Mustafa; El Sharkawy, Dina Ahmed (2020). "Expression of retinoid receptors in hand eczema". International Journal of Dermatology. 59 (5): 576–581. doi:10.1111/ijd.14830. ISSN 0011-9059.


The 2012 Chapel Hill Consensus Conference (CHCC) classified the vasculitides as follows:
Large Vessel Vasculitis
Takayasu arteritis
Giant cell arteritis
Medium vessel vasculitis
Polyarteritis nodosa
Kawasaki disease
Small vessel vasculitis
ANCA-associated vasculitis: Microscopic polyangiitis, Granulomatosis with polyangiitis (Wegener's), and Eosinophilic granulomatosis with polyangiitis (Churg-Strauss).
Immune complex small-vessel vasculitis: Anti-glomerular basement membrane disease, Cryoglobulinemic vasculitis, IgA vasculitis (Henoch-Schönlein), and Hypocomplementemic urticarial vasculitis (anti-C1q vasculitis)
Variable-vessel vasculitis
Behçet's syndrome
Cogan's syndrome
Single-organ vasculitis
Cutaneous leukocytoclastic angiitis
Cutaneous arteritis
Primary central nervous system vasculitis
Isolated aortitis
Vasculitis associated with systemic disease
Lupus vasculitis
Rheumatoid vasculitis
Sarcoid vasculitis
Others
Vasculitis associated with probable etiology
Hepatitis C virus-associated cryoglobulinemic vasculitis
Hepatitis B virus-associated vasculitis
Syphilis-associated aortitis
Drug-associated immune complex vasculitis
Drug-associated ANCA-associated vasculitis
Cancer-associated vasculitis
other

Diagnosis of PSV is based on a combination of clinical, laboratory, histopathological and radiological features

 
 
 
History suggestive of vasculitis
 
 
 
 
 
 
 
 
 
 
 
 
 
 
{{{ }}}Clinical Findings
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Laboratory tests C02= Additional tests
 
{{{ C02 }}}
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 


 
 
 
 
 
 
 
Induction of Remission
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Cyclophosphamide + Glucocorticoid
 
 
 
 
 
 
 
OR Rituximab + Glucocorticoid
 
 
 
 
 
 
 
No organ threatening involved: Mycophenolate Mofetyl or Methotrexate
 
 
 
 
 
 
 
 
Vital organ/life threatening/creatinine>500 mmol/L : Add Plasma exchange
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Disease control on Drug "Remission"
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Switch to Azathioprine or MTX & Taper Glucocorticoid
 
 
 
 
 
 
Disease control on Drug "Remission"
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
continue RTX & Taper Glucocorticoid
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Labs: To exclude vasculitis “mimics” and secondary causes Blood cultures

Echocardiogram

Hepatitis screen (B and C)

HIV test

Antiglomerular basement membrane antibody

Antiphospholipid antibodies

Antinuclear antibody

To assess extent of vasculitis Urine dipstick and microscopy (all patients)

Chest radiography (all patients)

Nerve conduction studies/electromyography/CK

To confirm diagnosis of vasculitis Biopsy and/or angiogram

To identify the specific type of vasculitis ANCA

Cryoglobulin

Complement levels

Eosinophil counts/IgE levels

Specific findings on biopsy (necrotising granulomatous inflammation, presence of IgA deposits, evidence of immune complex formation (or its absence)) [1]

Algorithm of small vs vasculitis dx: Bezerra, A. S., Polimanti, A. C., Fürst, R., & Corrêa, J. A. (2019). Algorithm for diagnosis of primary vasculitides. Jornal vascular brasileiro, 18, e20180092. https://doi.org/10.1590/1677-5449.009218

Algorithm for ttt of AAV: BSR and BHPR guideline for the management of adults with ANCA-associated vasculitis December 2014Rheumatology 53(12):2306-9 DOI:10.1093/rheumatology/ket445.


 
 
 
 
 
 
 
 
A01
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
B01
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C01
 
C02
 
C03
 
C04
 


 
 
 
 
 
 
 
 
A01
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
B01
 
B02
 
B03
 
B04
 
 
 
 
 
 
 
 
 
 
 
 
 
C01
 
C02
 
 
 
 
 
 
 
 
 
 
 
 
 
 
D01
 
D02
 
 
 
 
 
 
 
 
 
 
 
 
 
 
E01
 
E02
 
 
Resident
Survival
Guide
  1. ↑ Suresh E. (2006). Diagnostic approach to patients with suspected vasculitis. Postgraduate medical journal, 82(970), 483–488. https://doi.org/10.1136/pgmj.2005.042648
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