Fetal hydantoin syndrome: Difference between revisions

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{{SI}}
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{{CMG}}; {{AE}}
{{CMG}}; {{AE}} {{Kalpana Giri}}


==Overview==
==Overview==
Fetal hydantoin syndrome was first [[discovered]] by Meadow et al. in 1968. Manson and Frederic [[clarified]] the [[teratogenic]] effects of [[hydantoin]] in their [[epidemiological]] studies in 1973 and Hanson and Smith in 1975. Fetal hydantoin syndrome, [[characterized]] by [[altered growth]] and [[development]], has been well [[described]] in recent years in the [[fetus]] of [[epileptic]] mothers taking [[phenytoin]] or other [[hydantoin]] [[anticonvulsants]] during the [[gestational]] period.<ref name="pmid6263127">{{cite journal| author=Jimenez JF, Seibert RW, Char F, Brown RE, Seibert JJ| title=Melanotic neuroectodermal tumor of infancy and fetal hydantoin syndrome. | journal=Am J Pediatr Hematol Oncol | year= 1981 | volume= 3 | issue= 1 | pages= 9-15 | pmid=6263127 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6263127  }} </ref>It is understood that fetal hydantoin syndromes is the result of infants born to mothers with [[seizure]] disorders treated with [[anticonvulsant]] medications during pregnancy. There is also an [[association]] with [[EPHX1]] has been suggested. Although the exact [[pathogenesis]] of [[phenytoin]] (PTN) embryo toxicity is not clear, some possible [[mechanisms]] have been proposed. Phenytoin inhibits [[sodium]] (Na) and [[calcium]] (Ca) channels which act as membrane stabilizers, as a result of which [[free radicals]] are released and cause endothelial damage, [[myocardial depression]], [[bradycardia]], and consequently [[fetal hypoxia]]. [[Phenytoin]] induces [[cytochrome P450]] activation which ends up within the release of [[teratogenic]] [[free radicals]], sourced via the metabolism of [[epoxides]], [[folate]], and [[vitamin K]] within the [[liver]]. The severity of associated abnormalities will vary greatly from one infant to another. The characteristic features of fetal hydantoin synrome include abnormalities of [[growth]] such as pre and [[postnatal]] growth deficiency and [[microcephaly]] abnormalities of performance such as [[developmental]] delay or dull mentality to frank mental deficiency; and [[dysmorphic]] [[craniofacial]] features commonly including [[short nose]] with [[broad depressed bridge]] and inner [[epicanthic folds]], [[mild ocular hypertelorism]], [[ptosis]] of the eyelid, [[strabismus]], [[wide mouth]], [[sutural ridging]], and [[short neck]] with mild [[webbing]]; less commonly [[cleft lip]] and [[palate]], and limb anomalies including [[hypoplasia]] of the [[nails]] and [[distal phalanges]] with an increased frequency of low arch digital dermal ridge patterns, and fingerlike thumb. Less commonly children displaying these dysmorphic [[craniofacial]] and limb features were reported to have major anomalies in other systems, including [[cardiac anomalies]]. It was also shown an increased incidence of major [[genitourinary]] and central nervous system anomalies, more serious limb reduction defects, and [[diaphragmatic hernia]]. Fetal hydantoin syndrome may be [[caused]] by a combination of specific [[genetic and environmental]] factors. Common [[causes]] of fetal hydantoin syndrome may include [[anti-seizure]](anticonvulsant) drug [[phenytoin]] [[(Dilantin)]] during [[pregnancy]]. [[Fetal hydantoin syndrome]] must be [[differentiated]] from other diseases that cause [[Hypoplastic nails]] and [[growth retardation]] along with some similar [[facial features]] are also found in the [[Coffin-Siris]], [[Hypopiasia of distal phalanges]] in Noonan's syndrome and [[Nail hypoplasia]] in [[Robinson's disease]]. The exact [[incidence]] and [[prevalence]] of the fetal hydantoin syndrome is unknown.The [[risk]] appears to be 2-3 times greater than normal in the [[children]] of [[epileptic]] women taking [[anticonvulsant]] drugs than in the [[general population]]. The exact [[incidence]] and [[prevalence]] of the [[fetal hydantoin syndrome]] is unknown.The [[risk]] appears to be 2-3 times greater than normal in the [[children]] of [[epileptic women]] taking [[anticonvulsant drugs]] than in the [[general population]]. The [[risk]] of [[neurological impairment]] estimated to be 1% to 11% is 2 to 3 times [[higher]] than in [[the general population]]. The risk of [[oral clefts]] and [[cardiac anomalies]] is 5 times than others in [[hydantoin]] exposed infants. Less frequently observed [[abnormalities]] include [[microcephaly]], [[ocular defects]], [[hypospadias]], [[umbilical and inguinal hernias]]. Fetal hydantoin syndrome affects males and females equally. Common [[risk factors]] in the [[development]] of fetal hydantoin syndrome include exposure of fetus to [[antiepileptic]] drugs [[phenytoin]](Dilantin). There is insufficient evidence to recommend routine [[screening]] for fetal hydantoin syndrome. But In case fetus exposed in [[utero]] to [[phenytoin]], screening by [[cytogenetic analysis]], a careful screening by [[morphological]] [[ultrasound]] was recommended.Without termination of [[pregnancy]], the patient will develop conditions of severe [[respiratory distress]], [[multiple congenital anomalies]], including an [[imperforate]] anus, [[ambiguous genitalia]], [[dislocated hips]], [[clubfeet]], [[hypoplastic fingernails]], [[a short neck]], and a [[barrel-shaped thorax]], [[swollen thigh]], decrease [[ breath sound]] and [[cardiac murmur]] which may eventually lead to [[neonatal]] death. Common [[complications]] of fetal hydantoin syndrome is [[microcephaly]], [[growth deficiency]], [[congenital heart defects]], systemic abnormalities (nervous, renal, GI systems). The [[diagnosis]] is based on the clinical features along with a [[history]] of [[phenytoin]] exposure during [[pregnancy]]. [[Ultrasound]] may be helpful in the [[diagnosis]] of fetal hydantoin syndrome. Findings on ultrasound suggestive of fetal hydantoin syndrome includes [[gastroschisis]], [[sacral meningomyelocele]], absence of the [[upper limb]] [[lower limb]], clubfoot, Pectus carinatum, [[dilated right/left heart]] with [[peri- cardial effusion]]. reatment of individuals with fetal hydantoin syndrome depends on the particular [[manifestation]] of the [[disease]]. Individuals with [[congenital heart disease]] may require to undergo major [[corrective surgery]] soon after [[birth]]. Other individuals who have relatively [[minor]] health problems require no therapy. Patients with fetal hydantoin syndrome require to [[follow up]] and [[close monitoring]] of [[growth]], [[psychomotor]] [[craniofacial evaluation]], [[cardiac evaluation]].
Fetal hydantoin syndrome was first [[discovered]] by Meadow et al. in 1968. Manson and Frederic [[clarified]] the [[teratogenic]] effects of [[hydantoin]] in their [[epidemiological]] studies in 1973 and Hanson and Smith in 1975. Fetal hydantoin syndrome, [[characterized]] by [[altered growth]] and [[development]], has been well [[described]] in recent years in the [[fetus]] of [[epileptic]] mothers taking [[phenytoin]] or other [[hydantoin]] [[anticonvulsants]] during the [[gestational]] period.It is understood that fetal hydantoin syndromes are the result of infants born to mothers with [[seizure]] disorders treated with [[anticonvulsant]] medications during pregnancy. There is also an [[association]] with [[EPHX1]] has been suggested. Although the exact [[pathogenesis]] of [[phenytoin]] (PTN) embryotoxicity is not clear, some possible [[mechanisms]] have been proposed. Phenytoin inhibits [[sodium]] (Na) and [[calcium]] (Ca) channels which act as membrane stabilizers, as a result of which [[free radicals]] are released and cause endothelial damage, [[myocardial depression]], [[bradycardia]], and consequently [[fetal hypoxia]]. [[Phenytoin]] induces [[cytochrome P450]] activation which ends up within the release of [[teratogenic]] [[free radicals]], sourced via the metabolism of [[epoxides]], [[folate]], and [[vitamin K]] within the [[liver]]. The severity of associated abnormalities will vary greatly from one infant to another. The characteristic features of fetal hydantoin syndrome include abnormalities of [[growth]] such as pre and [[postnatal]] growth deficiency and [[microcephaly]] abnormalities of performance such as [[developmental]] delay or dull mentality to frank mental deficiency; and [[dysmorphic]] [[craniofacial]] features commonly including [[short nose]] with [[broad depressed bridge]] and inner [[epicanthic folds]], [[mild ocular hypertelorism]], [[ptosis]] of the eyelid, [[strabismus]], [[wide mouth]], [[sutural ridging]], and [[short neck]] with mild [[webbing]]; less commonly [[cleft lip]] and [[palate]], and limb anomalies including [[hypoplasia]] of the [[nails]] and [[distal phalanges]] with an increased frequency of low arch digital dermal ridge patterns, and fingerlike thumb. Less commonly children displaying these dysmorphic [[craniofacial]] and limb features were reported to have major anomalies in other systems, including [[cardiac anomalies]]. It was also shown an increased incidence of major [[genitourinary]] and central nervous system anomalies, more serious limb reduction defects, and [[diaphragmatic hernia]]. Fetal hydantoin syndrome may be [[caused]] by a combination of specific [[genetic and environmental]] factors. Common [[causes]] of fetal hydantoin syndrome may include the [[anti-seizure]](anticonvulsant) drug [[phenytoin]] [[(Dilantin)]] during [[pregnancy]]. Fetal hydantoin syndrome must be [[differentiated]] from other diseases that cause [[Hypoplastic nails]] and [[growth retardation]] along with some similar [[facial features]] are also found in the [[Coffin-Siris]], [[Hypoplasia of distal phalanges]] in Noonan's syndrome, and [[Nail hypoplasia]] in [[Robinson's disease]]. The exact [[incidence]] and [[prevalence]] of fetal hydantoin syndrome are unknown. The [[risk]] appears to be 2-3 times greater than normal in the [[children]] of [[epileptic]] women taking [[anticonvulsant]] drugs than in the [[general population]]. The exact [[incidence]] and [[prevalence]] of fetal hydantoin syndrome are unknown.The [[risk]] appears to be 2-3 times greater than normal in the [[children]] of [[epileptic women]] taking [[anticonvulsant drugs]] than in the [[general population]]. The [[risk]] of [[neurological impairment]] estimated to be 1% to 11% is 2 to 3 times [[higher]] than in [[the general population]]. The risk of [[oral clefts]] and [[cardiac anomalies]] is 5 times that of others in [[hydantoin]] exposed infants. Less frequently observed [[abnormalities]] include [[microcephaly]], [[ocular defects]], [[hypospadias]], [[umbilical and inguinal hernias]]. Fetal hydantoin syndrome affects males and females equally. Common [[risk factors]] in the [[development]] of fetal hydantoin syndrome include exposure of the fetus to [[antiepileptic]] drugs [[phenytoin]](Dilantin). There is insufficient evidence to recommend routine [[screening]] for fetal hydantoin syndrome. But In case the fetus is exposed in [[utero]] to [[phenytoin]], screening by [[cytogenetic analysis]], a careful screening by [[morphological]] [[ultrasound]] was recommended. Without termination of [[pregnancy]], the patient will develop conditions of severe [[respiratory distress]], [[multiple congenital anomalies]], including the [[imperforate]] anus, [[ambiguous genitalia]], [[dislocated hips]], [[clubfeet]], [[hypoplastic fingernails]], [[a short neck]], and a [[barrel-shaped thorax]], [[swollen thigh]], decreased [[ breath sound]] and [[cardiac murmur]] which may eventually lead to [[neonatal]] death. Common [[complications]] of fetal hydantoin syndrome are [[microcephaly]], [[growth deficiency]], [[congenital heart defects]], systemic abnormalities (nervous, renal, GI systems). The [[diagnosis]] is based on the clinical features along with a [[history]] of [[phenytoin]] exposure during [[pregnancy]]. [[Ultrasound]] may be helpful in the [[diagnosis]] of fetal hydantoin syndrome. Findings on ultrasound suggestive of fetal hydantoin syndrome include [[gastroschisis]], [[sacral meningomyelocele]], absence of the [[upper limb]] [[lower limb]], clubfoot, Pectus carinatum, [[dilated right/left heart]] with [[peri- cardial effusion|pericardial effusion]]. Treatment of individuals with fetal hydantoin syndrome depends on the particular [[manifestation]] of the [[disease]]. Individuals with [[congenital heart disease]] may require to undergo major [[corrective surgery]] soon after [[birth]]. Other individuals who have relatively [[minor]] health problems require no therapy. Patients with fetal hydantoin syndrome require [[follow-up]] and [[close monitoring]] of [[growth]], [[psychomotor]] [[craniofacial evaluation]], [[cardiac evaluation]].


==Historical Perspective==
==Historical Perspective==
Fetal hydantoin syndrome was first [[discovered]] by Meadow et al. in 1968. Manson and Frederic clarified the [[teratogenic]] effects of [[hydantoin]] in their [[epidemiological]] studies in 1973<ref name="pmid9677735">{{cite journal| author=Ozkinay F, Yenigün A, Kantar M, Ozkinay C, Avanoğlu A, Ulman I| title=Two siblings with fetal hydantoin syndrome. | journal=Turk J Pediatr | year= 1998 | volume= 40 | issue= 2 | pages= 273-8 | pmid=9677735 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9677735  }} </ref>and Hanson and Smith in 1975.<ref name="pmid25996397">{{cite journal| author=| title=Reorganized text. | journal=JAMA Otolaryngol Head Neck Surg | year= 2015 | volume= 141 | issue= 5 | pages= 428 | pmid=25996397 | doi=10.1001/jamaoto.2015.0540 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25996397  }} </ref>
Fetal hydantoin syndrome was first [[discovered]] by Meadow et al. in 1968. Manson and Frederic clarified the [[teratogenic]] effects of [[hydantoin]] in their [[epidemiological]] studies in 1973and Hanson and Smith in 1975.


==Classification==
==Classification==
Line 14: Line 13:


==Pathophysiology==
==Pathophysiology==
It is understood that fetal hydantoin syndromes is the result of infants born to mothers with [[seizure]] disorders treated with [[anticonvulsant]] medications during pregnancy are at an increased risk for [[teratogenic]] effects.<ref name="pmid23082254">{{cite journal| author=Singh R, Kumar N, Arora S, Bhandari R, Jain A| title=Fetal hydantoin syndrome and its anaesthetic implications: a case report. | journal=Case Rep Anesthesiol | year= 2012 | volume= 2012 | issue=  | pages= 370412 | pmid=23082254 | doi=10.1155/2012/370412 | pmc=3469078 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23082254  }} </ref>There is also an association with [[EPHX1]] has been suggested.<ref>{{OMIM|132810}}</ref> Although the exact pathogenesis of [[phenytoin]] (PTN) embryo toxicity is not clear, some possible mechanisms have been proposed.<ref name="pmid16611127">{{cite journal| author=Webster WS, Howe AM, Abela D, Oakes DJ| title=The relationship between cleft lip, maxillary hypoplasia, hypoxia and phenytoin. | journal=Curr Pharm Des | year= 2006 | volume= 12 | issue= 12 | pages= 1431-48 | pmid=16611127 | doi=10.2174/138161206776389868 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16611127  }} </ref> Phenytoin inhibits [[sodium]] (Na) and [[calcium]] (Ca) channels which act as membrane stabilizers, as a result of which [[free radicals]] are released and cause endothelial damage, [[myocardial depression]], [[bradycardia]], and consequently [[fetal hypoxia]]. [[Phenytoin]] induces [[cytochrome P450]] activation which ends up within the release of [[teratogenic]] [[free radicals]], sourced via the metabolism of [[epoxides]], [[folate]], and [[vitamin K]] within the [[liver]].<ref name="pmid24323366">{{cite journal| author=Nilsson MF, Ritchie H, Webster WS| title=The effect on rat embryonic heart rate of Na+, K+, and Ca2+ channel blockers, and the human teratogen phenytoin, changes with gestational age. | journal=Birth Defects Res B Dev Reprod Toxicol | year= 2013 | volume= 98 | issue= 5 | pages= 416-27 | pmid=24323366 | doi=10.1002/bdrb.21084 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24323366  }} </ref><ref name="pmid11283972">{{cite journal| author=Azarbayjani F, Danielsson BR| title=Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage. | journal=Teratology | year= 2001 | volume= 63 | issue= 3 | pages= 152-60 | pmid=11283972 | doi=10.1002/tera.1026 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11283972  }} </ref>The severity of associated abnormalities will vary greatly from one infant to another. The characteristic features of fetal hydantoin synrome include abnormalities of [[growth]] such as prenatal ([[media:Intra-uterine-growth-restriction.png|IUGR]]) and [[postnatal]] growth deficiency and [[microcephaly]] abnormalities of performance such as [[developmental]] delay or dull mentality to frank mental deficiency; and [[dysmorphic]] [[craniofacial]] features commonly including [[short nose]] with [[broad depressed bridge]] and inner [[epicanthic folds]], [[mild ocular hypertelorism]], [[ptosis]] of the eyelid, [[strabismus]], [[wide mouth]], [[sutural ridging]], and [[short neck]] with mild [[webbing]]; less commonly [[cleft lip]] and [[media:Incomplete-cleft-palate.jpg|cleft palate]], and limb anomalies including [[hypoplasia]] of the [[nails]] and [[distal phalanges]] with an increased frequency of low arch digital dermal ridge patterns, and fingerlike thumb ([[media:Triphalangeal-thumb.jpg|Triphalangeal-thumb]]). Less commonly children displaying these dysmorphic [[craniofacial]] and limb features were reported to have major anomalies in other systems, including [[cardiac anomalies]]. It was also shown an increased incidence of major [[genitourinary]] and central nervous system anomalies, more serious limb reduction defects, and [[diaphragmatic hernia]].<ref name="pmid7131169">{{cite journal| author=Hanson JW, Buehler BA| title=Fetal hydantoin syndrome: current status. | journal=J Pediatr | year= 1982 | volume= 101 | issue= 5 | pages= 816-8 | pmid=7131169 | doi=10.1016/s0022-3476(82)80339-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7131169  }} </ref>
It is understood that fetal hydantoin syndromes is the result of infants born to mothers with [[seizure]] disorders treated with [[anticonvulsant]] medications during pregnancy are at an increased risk for [[teratogenic]] effects.There is also an association with [[EPHX1]] has been suggested. Although the exact pathogenesis of [[phenytoin]] (PTN) embryotoxicity is not clear, some possible mechanisms have been proposed. Phenytoin inhibits [[sodium]] (Na) and [[calcium]] (Ca) channels which act as membrane stabilizers, as a result of which [[free radicals]] are released and cause endothelial damage, [[myocardial depression]], [[bradycardia]], and consequently [[fetal hypoxia]]. [[Phenytoin]] induces [[cytochrome P450]] activation which ends up within the release of [[teratogenic]] [[free radicals]], sourced via the metabolism of [[epoxides]], [[folate]], and [[vitamin K]] within the [[liver]].The severity of associated abnormalities will vary greatly from one infant to another. The characteristic features of fetal hydantoin syndrome include abnormalities of [[growth]] such as prenatal ([[Media:Intra-uterine-growth-restriction.png|IUGR]]) and [[postnatal]] growth deficiency and [[microcephaly]] abnormalities of performance such as [[developmental]] delay or dull mentality to frank mental deficiency; and [[dysmorphic]] [[craniofacial]] features commonly including [[short nose]] with [[broad depressed bridge]] and inner [[epicanthic folds]], [[mild ocular hypertelorism]], [[ptosis]] of the eyelid, [[strabismus]], [[wide mouth]], [[sutural ridging]], and [[short neck]] with mild [[webbing]]; less commonly [[cleft lip]] and [[Media:Incomplete-cleft-palate.jpg|cleft palate]], and limb anomalies including [[hypoplasia]] of the [[nails]] and [[distal phalanges]] with an increased frequency of low arch digital dermal ridge patterns, and fingerlike thumb ([[Media:Triphalangeal-thumb.jpg|Triphalangeal-thumb]]). Less commonly children displaying these dysmorphic [[craniofacial]] and limb features were reported to have major anomalies in other systems, including [[cardiac anomalies]]. It was also shown an increased incidence of major [[genitourinary]] and central nervous system anomalies, more serious limb reduction defects, and [[diaphragmatic hernia]].


==Causes==
==Causes==
Fetal hydantoin syndrome may be [[caused]] by a combination of specific [[genetic and environmental]] factors. Common [[causes]] of fetal hydantoin syndrome may include [[anti-seizure]](anticonvulsant) drug [[phenytoin]] [[(Dilantin)]] during [[pregnancy]].<ref name="pmid6263127">{{cite journal| author=Jimenez JF, Seibert RW, Char F, Brown RE, Seibert JJ| title=Melanotic neuroectodermal tumor of infancy and fetal hydantoin syndrome. | journal=Am J Pediatr Hematol Oncol | year= 1981 | volume= 3 | issue= 1 | pages= 9-15 | pmid=6263127 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6263127  }} </ref>
Fetal hydantoin syndrome may be [[caused]] by a combination of specific [[genetic and environmental]] factors. Common [[causes]] of fetal hydantoin syndrome may include the [[anti-seizure]](anticonvulsant) drug [[phenytoin]] [[(Dilantin)]] during [[pregnancy]].


==Differential Diagnosis==
==Differential Diagnosis==
[[Fetal hydantoin syndrome]] must be [[differentiated]] from other diseases that cause [[Hypoplastic nails]] and [[growth retardation]] along with some
[[Fetal hydantoin syndrome]] must be [[differentiated]] from other diseases that cause [[Hypoplastic nails]] and [[growth retardation]] along with some
similar [[facial features]] are also found in the [[Coffin-Siris]],<ref name="pmid50428">{{cite journal| author=Hanson JW, Smith DW| title=The fetal hydantoin syndrome. | journal=J Pediatr | year= 1975 | volume= 87 | issue= 2 | pages= 285-90 | pmid=50428 | doi=10.1016/s0022-3476(75)80604-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=50428  }} </ref> [[Hypopiasia of distal phalanges]] in Noonan's syndrome and [[Nail hypoplasia]] in [[Robinson's disease]]<ref name="pmid2501774">{{cite journal| author=Nanda A, Kaur S, Bhakoo ON, Kapoor MM, Kanwar AJ| title=Fetal hydantoin syndrome: a case report. | journal=Pediatr Dermatol | year= 1989 | volume= 6 | issue= 2 | pages= 130-3 | pmid=2501774 | doi=10.1111/j.1525-1470.1989.tb01011.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2501774  }} </ref>
similar [[facial features]] are also found in the [[Coffin-Siris]], [[Hypoplasia of distal phalanges]] in Noonan's syndrome, and [[Nail hypoplasia]] in [[Robinson's disease|Robinson's disease.]]


==Epidemiology and Demographics==
==Epidemiology and Demographics==
The exact [[incidence]] and [[prevalence]] of the [[fetal hydantoin syndrome]] is unknown.The [[risk]] appears to be 2-3 times greater than normal in the [[children]] of [[epileptic women]] taking [[anticonvulsant drugs]] than in the [[general population]].<ref name="pmid4116552">{{cite journal| author=Speidel BD, Meadow SR| title=Maternal epilepsy and abnormalities of the fetus and newborn. | journal=Lancet | year= 1972 | volume= 2 | issue= 7782 | pages= 839-43 | pmid=4116552 | doi=10.1016/s0140-6736(72)92209-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4116552  }} </ref> The [[risk]] of [[neurological impairment]] estimated to be 1% to 11% is 2 to 3 times [[higher]] than in [[the general population]]. The risk of [[oral clefts]] and [[cardiac anomalies]] is 5 times than others in [[hydantoin]] exposed infants. Less frequently observed [[abnormalities]] include [[microcephaly]], [[ocular defects]], [[hypospadias]], [[umbilical and inguinal hernias]].<ref name="pmid23082254">{{cite journal| author=Singh R, Kumar N, Arora S, Bhandari R, Jain A| title=Fetal hydantoin syndrome and its anaesthetic implications: a case report. | journal=Case Rep Anesthesiol | year= 2012 | volume= 2012 | issue=  | pages= 370412 | pmid=23082254 | doi=10.1155/2012/370412 | pmc=3469078 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23082254  }} </ref> Fetal hydantoin syndrome affects males and females equally.
The exact [[incidence]] and [[prevalence]] of fetal hydantoin syndrome are unknown. The [[risk]] appears to be 2-3 times greater than normal in the [[children]] of [[epileptic women]] taking [[anticonvulsant drugs]] than in the [[general population]]. The [[risk]] of [[neurological impairment]] estimated to be 1% to 11% is 2 to 3 times [[higher]] than in [[the general population]]. The risk of [[oral clefts]] and [[cardiac anomalies]] is 5 times that of others in [[hydantoin]] exposed infants. Less frequently observed [[abnormalities]] include [[microcephaly]], [[ocular defects]], [[hypospadias]], [[umbilical and inguinal hernias]].


==Risk factors==
==Risk factors==
Common [[risk factors]] in the [[development]] of fetal hydantoin syndrome include exposure of fetus to [[antiepileptic]] drugs [[phenytoin]](Dilantin)
Common [[risk factors]] in the [[development]] of fetal hydantoin syndrome include exposure of fetus to [[antiepileptic]] drugs [[phenytoin]](Dilantin).


==Screening==
==Screening==
There is insufficient evidence to recommend routine [[screening]] for fetal hydantoin syndrome. But In case fetus exposed in [[utero]] to [[phenytoin]], screening by [[cytogenetic analysis]], a careful screening by [[morphological]] [[ultrasound]] was recommended.<ref name="urlA case of prenatal diagnosis of fetal hydantoin syndrome by ultrasound">{{cite web |url=https://doi.org/10.1590/S1415-47571999000200002 |title=A case of prenatal diagnosis of fetal hydantoin syndrome by ultrasound |format= |work= |accessdate=}}</ref>
There is insufficient evidence to recommend routine [[screening]] for fetal hydantoin syndrome. But In case the fetus is exposed in [[utero]] to [[phenytoin]], screening by [[cytogenetic analysis]], a careful screening by [[morphological]] [[ultrasound]] was recommended.


==Natural History, Complications, and Prognosis==
==Natural History, Complications, and Prognosis==
Without termination of [[pregnancy]], the patient will develop conditions of severe [[respiratory distress]], [[multiple congenital anomalies]], including an [[imperforate]]
Without termination of [[pregnancy]], the patient will develop conditions of severe [[respiratory distress]], [[multiple congenital anomalies]], including the [[imperforate]]
anus, [[ambiguous genitalia]], [[dislocated hips]], [[clubfeet]], [[hypoplastic fingernails]], [[a short neck]], and a [[barrel-shaped thorax]], [[swollen thigh]], decrease [[ breath sound]] and [[cardiac murmur]] which may eventually lead to [[neonatal]] death.<ref name="pmid6702795">{{cite journal| author=Kogutt MS, Young LW| title=Radiological case of the month. Fetal hydantoin syndrome. | journal=Am J Dis Child | year= 1984 | volume= 138 | issue= 4 | pages= 405-6 | pmid=6702795 | doi=10.1001/archpedi.1984.02140420071021 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6702795  }} </ref>Common [[complications]] of fetal hydantoin syndrome is [[microcephaly]], [[growth deficiency]], [[congenital heart defects]], systemic abnormalities (nervous, renal, GI systems).<ref name="pmid23082254">{{cite journal| author=Singh R, Kumar N, Arora S, Bhandari R, Jain A| title=Fetal hydantoin syndrome and its anaesthetic implications: a case report. | journal=Case Rep Anesthesiol | year= 2012 | volume= 2012 | issue=  | pages= 370412 | pmid=23082254 | doi=10.1155/2012/370412 | pmc=3469078 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23082254  }} </ref>
anus, [[ambiguous genitalia]], [[dislocated hips]], [[clubfeet]], [[hypoplastic fingernails]], [[a short neck]], and a [[barrel-shaped thorax]], [[swollen thigh]], decreased [[ breath sound]] and [[cardiac murmur]] which may eventually lead to [[neonatal]] death. Common [[complications]] of fetal hydantoin syndrome are [[microcephaly]], [[growth deficiency]], [[congenital heart defects]], systemic abnormalities (nervous, renal, GI systems).


==Diagnosis==
==Diagnosis==
===Diagnostic Study of Choice===
===Diagnostic Study of Choice===
There are no established [[criteria]] for the [[diagnosis]] of fetal hydantoin syndrome. The [[diagnosis]] is based on the clinical features along with a [[history]] of [[phenytoin]] exposure during [[pregnancy]].<ref name="pmid2501774">{{cite journal| author=Nanda A, Kaur S, Bhakoo ON, Kapoor MM, Kanwar AJ| title=Fetal hydantoin syndrome: a case report. | journal=Pediatr Dermatol | year= 1989 | volume= 6 | issue= 2 | pages= 130-3 | pmid=2501774 | doi=10.1111/j.1525-1470.1989.tb01011.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2501774  }} </ref>
There are no established [[criteria]] for the [[diagnosis]] of fetal hydantoin syndrome. The [[diagnosis]] is based on the clinical features along with a [[history]] of [[phenytoin]] exposure during [[pregnancy]].


===History and Symptoms===
===History and Symptoms===
Line 44: Line 43:


===Physical Examination===
===Physical Examination===
Common physical examination findings of fetal hydantoin syndrome include:<ref name="pmid28578158">{{cite journal| author=Hegde A, Kaur A, Sood A, Dhanorkar M, Varma HT, Singh G | display-authors=etal| title=Fetal Hydantoin Syndrome. | journal=J Pediatr | year= 2017 | volume= 188 | issue=  | pages= 304 | pmid=28578158 | doi=10.1016/j.jpeds.2017.05.018 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28578158  }} </ref>
Common physical examination findings of fetal hydantoin syndrome include:


*Microcephaly,
*Microcephaly
*Distinctive facial ([[cleft lip and palate]]) and [[media:Congenital-upper-and-lower-limbs-deficiencies.jpg|limb anomalies]]
*Distinctive facial ([[cleft lip and palate]]) and [[Media:Congenital-upper-and-lower-limbs-deficiencies.jpg|limb anomalies]]
*[[Ocular defects]]
*[[Ocular defects]]
*[[Growth deficiency]]
*[[Growth deficiency]]
*[[Congenital heart defects]], [[cardiac rhythm disturbances]]
*[[Congenital heart defects]], [[cardiac rhythm disturbances]]
*Variable systemic abnormalities involving the [[nervous]], [[renal]], and [[gastrointestinal systems]]
*Variable systemic abnormalities involving the [[nervous]], [[renal]], and [[gastrointestinal systems]]
*[[Congenital heart]] diseases associated with fetal hydantoin syndrome sunch as [[pulmonary]] or [[aortic valvular stenosis]], [[coarctation of aorta]], [[patent ductus arteriosus]], and [[ventricular septal defects]].
*[[Congenital heart]] diseases associated with fetal hydantoin syndrome such as [[pulmonary]] or [[aortic valvular stenosis]], [[coarctation of the aorta]], [[patent ductus arteriosus]], and [[ventricular septal defects]].


===Laboratory Findings===
===Laboratory Findings===
Line 60: Line 59:


===Echocardiography===
===Echocardiography===
[[Echocardiography]] may be helpful in the [[diagnosis]] of fetal hydantoin syndrome. Findings on [[echocardiography]] suggestive of [[pulmonary]] or [[aortic valvular stenosis]], [[coarctation of aorta]], [[patent ductus arteriosus]], and [[ventricular septal defects]].
[[Echocardiography]] may be helpful in the [[diagnosis]] of fetal hydantoin syndrome. Findings on [[echocardiography]] suggestive of [[pulmonary]] or [[aortic valvular stenosis]], [[coarctation of the aorta]], [[patent ductus arteriosus]], and [[ventricular septal defects]].


===X Ray===
===X Ray===
An [[X-ray]] may be helpful in the [[diagnosis]] of fetal hydantoin syndrome. Findings on [[X-ray]] diagnostic of fetal hydantoin syndrome depends on the [[clinical features]] and include an [[absence of carpal]], [[metacarpal]], and [[phalangeal bone]], [[hypoplasia of the nails]] and [[distal phalanges]], [[Hyperphalangism]], [[Pseudohyperphalangism]], [[Adactyly]]/[[biphalangeal]] digits/absent nails [[Unilateral acheiria]], [[congenital heart disease]]. <ref name="pmid8723073">{{cite journal| author=Sabry MA, Farag TI| title=Hand anomalies in fetal-hydantoin syndrome: from nail/phalangeal hypoplasia to unilateral acheiria. | journal=Am J Med Genet | year= 1996 | volume= 62 | issue= 4 | pages= 410-2 | pmid=8723073 | doi=10.1002/ajmg.1320620403 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8723073 }} </ref> [[image:Ventricular-septal-defect.jpg|Frame|right|100px|X ray showing VSD - Case courtesy of Assoc Prof Frank Gaillard, Radiopaedia.org, rID: 7445]]
An [[X-ray]] may be helpful in the [[diagnosis]] of fetal hydantoin syndrome. Findings on [[X-ray]] diagnostic of fetal hydantoin syndrome depends on the [[clinical features]] and include an [[absence of carpal]], [[metacarpal]], and [[phalangeal bone]], [[hypoplasia of the nails]], and [[distal phalanges]], [[Hyperphalangism]], [[Adactyly]]/[[biphalangeal]] digits/absent nails [[Unilateral acheiria]], [[congenital heart disease]].  
 
===Ultrasound===
[[Ultrasound]] may be helpful in the [[diagnosis]] of fetal hydantoin syndrome. Findings on ultrasound suggestive of fetal hydantoin syndrome include [[gastroschisis]], [[sacral meningomyelocele]], absence of the [[upper limb]] [[lower limb]], clubfoot, Pectus carinatum. [[dilated right/left heart]] with [[peri- cardial effusion|pericardial effusion]] [[image:Cleft-lip (1).JPG|enframed|right|50px|Usg showing cleft lip - Case courtesy of Dr Praveen Jha, Radiopaedia.org, rID: 16181]]
<br style="clear:left" />




===Ultrasound===
[[Ultrasound]] may be helpful in the [[diagnosis]] of fetal hydantoin syndrome. Findings on ultrasound suggestive of fetal hydantoin syndrome includes [[gastroschisis]], [[sacral meningomyelocele]], absence of the [[upper limb]] [[lower limb]], clubfoot, Pectus carinatum.<ref name="urlA case of prenatal diagnosis of fetal hydantoin syndrome by ultrasound">{{cite web |url=https://doi.org/10.1590/S1415-47571999000200002 |title=A case of [[prenatal]] [[diagnosis]] of fetal hydantoin syndrome by [[ultrasound]] |format= |work= |accessdate=}}</ref> [[dilated right/left heart]] with [[peri- cardial effusion]]<ref name="pmid28578158">{{cite journal| author=Hegde A, Kaur A, Sood A, Dhanorkar M, Varma HT, Singh G | display-authors=etal| title=Fetal Hydantoin Syndrome. | journal=J Pediatr | year= 2017 | volume= 188 | issue=  | pages= 304 | pmid=28578158 | doi=10.1016/j.jpeds.2017.05.018 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28578158  }} </ref>


===CT scan===
===CT scan===
Line 75: Line 76:
There are no other [[imaging]] findings associated with fetal hydantoin syndrome.
There are no other [[imaging]] findings associated with fetal hydantoin syndrome.
===Other Diagnostic Studies===
===Other Diagnostic Studies===
Other [[diagnostic]] studies for fetal hydantoin syndrome include [[amniocentesis]] demonstrates, low [[epoxide hydrolase]] activity<ref name="pmid2336087">{{cite journal| author=Buehler BA, Delimont D, van Waes M, Finnell RH| title=Prenatal prediction of risk of the fetal hydantoin syndrome. | journal=N Engl J Med | year= 1990 | volume= 322 | issue= 22 | pages= 1567-72 | pmid=2336087 | doi=10.1056/NEJM199005313222204 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2336087  }} </ref>
Other [[diagnostic]] studies for fetal hydantoin syndrome include [[amniocentesis]] demonstrates, low [[epoxide hydrolase]] activity
==Treatment==
==Treatment==
===Medical Therapy===
===Medical Therapy===
Treatment of individuals with fetal hydantoin syndrome depends on the particular [[manifestation]] of the [[disease]]. Individuals with [[congenital heart disease]] may require to undergo major [[corrective surgery]] soon after [[birth]]. Other individuals who have relatively [[minor]] health problems require no therapy. Patients with fetal hydantoin syndrome require to [[follow up]] and [[close monitoring]] of [[growth]], [[psychomotor]] [[craniofacial evaluation]], [[cardiac evaluation]].<ref name="pmid23082254">{{cite journal| author=Singh R, Kumar N, Arora S, Bhandari R, Jain A| title=Fetal hydantoin syndrome and its anaesthetic implications: a case report. | journal=Case Rep Anesthesiol | year= 2012 | volume= 2012 | issue=  | pages= 370412 | pmid=23082254 | doi=10.1155/2012/370412 | pmc=3469078 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23082254  }} </ref>
Treatment of individuals with fetal hydantoin syndrome depends on the particular [[manifestation]] of the [[disease]]. Individuals with [[congenital heart disease]] may require to undergo major [[corrective surgery]] soon after [[birth]]. Other individuals who have relatively [[minor]] health problems require no therapy. Patients with fetal hydantoin syndrome require [[follow-up]] and [[close monitoring]] of [[growth]], [[psychomotor]] [[craniofacial evaluation]], [[cardiac evaluation]].


===Surgery===
===Surgery===
Treatment of individuals with fetal hydantoin syndrome depends on the particular [[manifestation]] of the [[disease]]. Individuals with defects of bone require [[orthopedic surgery]], [[nervous system]] require [[neurosurgery]], [[cleft lip]] or [[cleft palate]] surgery and [[congenital heart disease]] may require to undergo major [[corrective surgery]] soon after [[birth]]. Other individuals who have relatively [[minor]] health problems require no therapy.<ref name="pmid23082254">{{cite journal| author=Singh R, Kumar N, Arora S, Bhandari R, Jain A| title=Fetal hydantoin syndrome and its anaesthetic implications: a case report. | journal=Case Rep Anesthesiol | year= 2012 | volume= 2012 | issue=  | pages= 370412 | pmid=23082254 | doi=10.1155/2012/370412 | pmc=3469078 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23082254  }} </ref>
Treatment of individuals with fetal hydantoin syndrome depends on the particular [[manifestation]] of the [[disease]]. Individuals with defects of bone require [[orthopedic surgery]], the [[nervous system]] requires [[neurosurgery]], [[cleft lip]] or [[cleft palate]] surgery and [[congenital heart disease]] may require to undergo major [[corrective surgery]] soon after [[birth]]. Other individuals who have relatively [[minor]] health problems require no therapy.


==Prevention==
==Prevention==


===Primary Prevention===
===Primary Prevention===
Effective measures for the primary prevention of fetal hydantoin syndrome include<ref name="pmid15610193">{{cite journal| author=Oguni M, Osawa M| title=Epilepsy and pregnancy. | journal=Epilepsia | year= 2004 | volume= 45 Suppl 8 | issue=  | pages= 37-41 | pmid=15610193 | doi=10.1111/j.0013-9580.2004.458008.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15610193  }} </ref>
Effective measures for the [[primary prevention]] of fetal hydantoin syndrome include:
*changing AED from [[polytherapy]] to [[monotherapy]] before [[pregnancy]]
 
*decreasing the serum concentration of AEDs to the lowest levels possible without losing seizure control
*Changing AED from [[polytherapy]] to [[monotherapy]] before [[pregnancy]]
*especially reducing PHT serum levels, supplementation with folate before pregnancy
*Decreasing the serum concentration of AEDs to the lowest levels possible without losing seizure control
*regular check‐up of the AED serum concentrations, folate, and α‐fetoprotein (AFP) values
*Reducing serum level of PHT and supplementation with folate before pregnancy
*counseling with parents regarding the risk of pregnancy and malformations
*Regular check‐up of the AED serum concentrations, [[folate]], and α‐fetoprotein ([[AFP]]) values
*regular check‐up of the fetus directly with ultrasonography.
*Counseling with parents regarding the risk of pregnancy and malformations
*Regular check‐up of the fetus directly with [[ultrasonography]]


===Secondary Prevention===
===Secondary Prevention===
Effective [[measures]] for the [[secondary prevention]] of fetal hydantoin syndrome include<ref name="pmid15610193">{{cite journal| author=Oguni M, Osawa M| title=Epilepsy and pregnancy. | journal=Epilepsia | year= 2004 | volume= 45 Suppl 8 | issue=  | pages= 37-41 | pmid=15610193 | doi=10.1111/j.0013-9580.2004.458008.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15610193  }} </ref>
Effective [[measures]] for the [[secondary prevention]] of fetal hydantoin syndrome include  
 
*Periodic [[health]] checks of [[psychomotor]] and [[physical development]].
*Periodic [[health]] checks of [[psychomotor]] and [[physical development]].
*[[Electroencephalography]]: Annually
*[[Electroencephalography]]: Annually
Line 101: Line 104:


==References==
==References==
<references />

Latest revision as of 05:08, 4 June 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kalpana Giri, MBBS[2]

Overview

Fetal hydantoin syndrome was first discovered by Meadow et al. in 1968. Manson and Frederic clarified the teratogenic effects of hydantoin in their epidemiological studies in 1973 and Hanson and Smith in 1975. Fetal hydantoin syndrome, characterized by altered growth and development, has been well described in recent years in the fetus of epileptic mothers taking phenytoin or other hydantoin anticonvulsants during the gestational period.It is understood that fetal hydantoin syndromes are the result of infants born to mothers with seizure disorders treated with anticonvulsant medications during pregnancy. There is also an association with EPHX1 has been suggested. Although the exact pathogenesis of phenytoin (PTN) embryotoxicity is not clear, some possible mechanisms have been proposed. Phenytoin inhibits sodium (Na) and calcium (Ca) channels which act as membrane stabilizers, as a result of which free radicals are released and cause endothelial damage, myocardial depression, bradycardia, and consequently fetal hypoxia. Phenytoin induces cytochrome P450 activation which ends up within the release of teratogenic free radicals, sourced via the metabolism of epoxides, folate, and vitamin K within the liver. The severity of associated abnormalities will vary greatly from one infant to another. The characteristic features of fetal hydantoin syndrome include abnormalities of growth such as pre and postnatal growth deficiency and microcephaly abnormalities of performance such as developmental delay or dull mentality to frank mental deficiency; and dysmorphic craniofacial features commonly including short nose with broad depressed bridge and inner epicanthic folds, mild ocular hypertelorism, ptosis of the eyelid, strabismus, wide mouth, sutural ridging, and short neck with mild webbing; less commonly cleft lip and palate, and limb anomalies including hypoplasia of the nails and distal phalanges with an increased frequency of low arch digital dermal ridge patterns, and fingerlike thumb. Less commonly children displaying these dysmorphic craniofacial and limb features were reported to have major anomalies in other systems, including cardiac anomalies. It was also shown an increased incidence of major genitourinary and central nervous system anomalies, more serious limb reduction defects, and diaphragmatic hernia. Fetal hydantoin syndrome may be caused by a combination of specific genetic and environmental factors. Common causes of fetal hydantoin syndrome may include the anti-seizure(anticonvulsant) drug phenytoin (Dilantin) during pregnancy. Fetal hydantoin syndrome must be differentiated from other diseases that cause Hypoplastic nails and growth retardation along with some similar facial features are also found in the Coffin-Siris, Hypoplasia of distal phalanges in Noonan's syndrome, and Nail hypoplasia in Robinson's disease. The exact incidence and prevalence of fetal hydantoin syndrome are unknown. The risk appears to be 2-3 times greater than normal in the children of epileptic women taking anticonvulsant drugs than in the general population. The exact incidence and prevalence of fetal hydantoin syndrome are unknown.The risk appears to be 2-3 times greater than normal in the children of epileptic women taking anticonvulsant drugs than in the general population. The risk of neurological impairment estimated to be 1% to 11% is 2 to 3 times higher than in the general population. The risk of oral clefts and cardiac anomalies is 5 times that of others in hydantoin exposed infants. Less frequently observed abnormalities include microcephaly, ocular defects, hypospadias, umbilical and inguinal hernias. Fetal hydantoin syndrome affects males and females equally. Common risk factors in the development of fetal hydantoin syndrome include exposure of the fetus to antiepileptic drugs phenytoin(Dilantin). There is insufficient evidence to recommend routine screening for fetal hydantoin syndrome. But In case the fetus is exposed in utero to phenytoin, screening by cytogenetic analysis, a careful screening by morphological ultrasound was recommended. Without termination of pregnancy, the patient will develop conditions of severe respiratory distress, multiple congenital anomalies, including the imperforate anus, ambiguous genitalia, dislocated hips, clubfeet, hypoplastic fingernails, a short neck, and a barrel-shaped thorax, swollen thigh, decreased breath sound and cardiac murmur which may eventually lead to neonatal death. Common complications of fetal hydantoin syndrome are microcephaly, growth deficiency, congenital heart defects, systemic abnormalities (nervous, renal, GI systems). The diagnosis is based on the clinical features along with a history of phenytoin exposure during pregnancy. Ultrasound may be helpful in the diagnosis of fetal hydantoin syndrome. Findings on ultrasound suggestive of fetal hydantoin syndrome include gastroschisis, sacral meningomyelocele, absence of the upper limb lower limb, clubfoot, Pectus carinatum, dilated right/left heart with pericardial effusion. Treatment of individuals with fetal hydantoin syndrome depends on the particular manifestation of the disease. Individuals with congenital heart disease may require to undergo major corrective surgery soon after birth. Other individuals who have relatively minor health problems require no therapy. Patients with fetal hydantoin syndrome require follow-up and close monitoring of growth, psychomotor craniofacial evaluation, cardiac evaluation.

Historical Perspective

Fetal hydantoin syndrome was first discovered by Meadow et al. in 1968. Manson and Frederic clarified the teratogenic effects of hydantoin in their epidemiological studies in 1973and Hanson and Smith in 1975.

Classification

There is no established system for the classification of Fetal hydantoin syndrome.

Pathophysiology

It is understood that fetal hydantoin syndromes is the result of infants born to mothers with seizure disorders treated with anticonvulsant medications during pregnancy are at an increased risk for teratogenic effects.There is also an association with EPHX1 has been suggested. Although the exact pathogenesis of phenytoin (PTN) embryotoxicity is not clear, some possible mechanisms have been proposed. Phenytoin inhibits sodium (Na) and calcium (Ca) channels which act as membrane stabilizers, as a result of which free radicals are released and cause endothelial damage, myocardial depression, bradycardia, and consequently fetal hypoxia. Phenytoin induces cytochrome P450 activation which ends up within the release of teratogenic free radicals, sourced via the metabolism of epoxides, folate, and vitamin K within the liver.The severity of associated abnormalities will vary greatly from one infant to another. The characteristic features of fetal hydantoin syndrome include abnormalities of growth such as prenatal (IUGR) and postnatal growth deficiency and microcephaly abnormalities of performance such as developmental delay or dull mentality to frank mental deficiency; and dysmorphic craniofacial features commonly including short nose with broad depressed bridge and inner epicanthic folds, mild ocular hypertelorism, ptosis of the eyelid, strabismus, wide mouth, sutural ridging, and short neck with mild webbing; less commonly cleft lip and cleft palate, and limb anomalies including hypoplasia of the nails and distal phalanges with an increased frequency of low arch digital dermal ridge patterns, and fingerlike thumb (Triphalangeal-thumb). Less commonly children displaying these dysmorphic craniofacial and limb features were reported to have major anomalies in other systems, including cardiac anomalies. It was also shown an increased incidence of major genitourinary and central nervous system anomalies, more serious limb reduction defects, and diaphragmatic hernia.

Causes

Fetal hydantoin syndrome may be caused by a combination of specific genetic and environmental factors. Common causes of fetal hydantoin syndrome may include the anti-seizure(anticonvulsant) drug phenytoin (Dilantin) during pregnancy.

Differential Diagnosis

Fetal hydantoin syndrome must be differentiated from other diseases that cause Hypoplastic nails and growth retardation along with some similar facial features are also found in the Coffin-Siris, Hypoplasia of distal phalanges in Noonan's syndrome, and Nail hypoplasia in Robinson's disease.

Epidemiology and Demographics

The exact incidence and prevalence of fetal hydantoin syndrome are unknown. The risk appears to be 2-3 times greater than normal in the children of epileptic women taking anticonvulsant drugs than in the general population. The risk of neurological impairment estimated to be 1% to 11% is 2 to 3 times higher than in the general population. The risk of oral clefts and cardiac anomalies is 5 times that of others in hydantoin exposed infants. Less frequently observed abnormalities include microcephaly, ocular defects, hypospadias, umbilical and inguinal hernias.

Risk factors

Common risk factors in the development of fetal hydantoin syndrome include exposure of fetus to antiepileptic drugs phenytoin(Dilantin).

Screening

There is insufficient evidence to recommend routine screening for fetal hydantoin syndrome. But In case the fetus is exposed in utero to phenytoin, screening by cytogenetic analysis, a careful screening by morphological ultrasound was recommended.

Natural History, Complications, and Prognosis

Without termination of pregnancy, the patient will develop conditions of severe respiratory distress, multiple congenital anomalies, including the imperforate anus, ambiguous genitalia, dislocated hips, clubfeet, hypoplastic fingernails, a short neck, and a barrel-shaped thorax, swollen thigh, decreased breath sound and cardiac murmur which may eventually lead to neonatal death. Common complications of fetal hydantoin syndrome are microcephaly, growth deficiency, congenital heart defects, systemic abnormalities (nervous, renal, GI systems).

Diagnosis

Diagnostic Study of Choice

There are no established criteria for the diagnosis of fetal hydantoin syndrome. The diagnosis is based on the clinical features along with a history of phenytoin exposure during pregnancy.

History and Symptoms

The patient with fetal hydantoin syndrome has a positive history of exposure to phenytoin during pregnancy. Common symptoms of fetal hydantoin syndrome include microcephaly, mental retardation, limb defects including hypoplastic nails and distal phalanges, heart defects.

Physical Examination

Common physical examination findings of fetal hydantoin syndrome include:

Laboratory Findings

There are no diagnostic laboratory findings associated with fetal hydantoin syndrome.

Electrocardiogram

There are no ECG findings associated with fetal hydantoin syndrome.

Echocardiography

Echocardiography may be helpful in the diagnosis of fetal hydantoin syndrome. Findings on echocardiography suggestive of pulmonary or aortic valvular stenosis, coarctation of the aorta, patent ductus arteriosus, and ventricular septal defects.

X Ray

An X-ray may be helpful in the diagnosis of fetal hydantoin syndrome. Findings on X-ray diagnostic of fetal hydantoin syndrome depends on the clinical features and include an absence of carpal, metacarpal, and phalangeal bone, hypoplasia of the nails, and distal phalanges, Hyperphalangism, Adactyly/biphalangeal digits/absent nails Unilateral acheiria, congenital heart disease.

Ultrasound

Ultrasound may be helpful in the diagnosis of fetal hydantoin syndrome. Findings on ultrasound suggestive of fetal hydantoin syndrome include gastroschisis, sacral meningomyelocele, absence of the upper limb lower limb, clubfoot, Pectus carinatum. dilated right/left heart with pericardial effusion

Usg showing cleft lip - Case courtesy of Dr Praveen Jha, Radiopaedia.org, rID: 16181



CT scan

There are no CT scan findings associated with fetal hydantoin syndrome.

Other Imaging Findings

There are no other imaging findings associated with fetal hydantoin syndrome.

Other Diagnostic Studies

Other diagnostic studies for fetal hydantoin syndrome include amniocentesis demonstrates, low epoxide hydrolase activity

Treatment

Medical Therapy

Treatment of individuals with fetal hydantoin syndrome depends on the particular manifestation of the disease. Individuals with congenital heart disease may require to undergo major corrective surgery soon after birth. Other individuals who have relatively minor health problems require no therapy. Patients with fetal hydantoin syndrome require follow-up and close monitoring of growth, psychomotor craniofacial evaluation, cardiac evaluation.

Surgery

Treatment of individuals with fetal hydantoin syndrome depends on the particular manifestation of the disease. Individuals with defects of bone require orthopedic surgery, the nervous system requires neurosurgery, cleft lip or cleft palate surgery and congenital heart disease may require to undergo major corrective surgery soon after birth. Other individuals who have relatively minor health problems require no therapy.

Prevention

Primary Prevention

Effective measures for the primary prevention of fetal hydantoin syndrome include:

  • Changing AED from polytherapy to monotherapy before pregnancy
  • Decreasing the serum concentration of AEDs to the lowest levels possible without losing seizure control
  • Reducing serum level of PHT and supplementation with folate before pregnancy
  • Regular check‐up of the AED serum concentrations, folate, and α‐fetoprotein (AFP) values
  • Counseling with parents regarding the risk of pregnancy and malformations
  • Regular check‐up of the fetus directly with ultrasonography

Secondary Prevention

Effective measures for the secondary prevention of fetal hydantoin syndrome include

References