Progressive multifocal leukoencephalopathy: Difference between revisions
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{{ | __NOTOC__ | ||
{{Progressive multifocal leukoencephalopathy}} | |||
{{About1|JC virus}} | |||
'''For patient information click [[Progressive multifocal leukoencephalopathy (patient information)|here]]''' | |||
{{CMG}} | {{CMG}} | ||
{{SK}} Progressive multifocal leucoencephalopathy, Multifocal leucoencephalopathy, Multifocal leukoencephalopathy, PML, PMLE | |||
==[[Progressive multifocal leukoencephalopathy overview|Overview]]== | ==[[Progressive multifocal leukoencephalopathy overview|Overview]]== | ||
==[[Progressive multifocal leukoencephalopathy historical perspective|Historical Perspective]]== | ==[[Progressive multifocal leukoencephalopathy historical perspective|Historical Perspective]]== | ||
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==[[Progressive multifocal leukoencephalopathy pathophysiology|Pathophysiology]]== | ==[[Progressive multifocal leukoencephalopathy pathophysiology|Pathophysiology]]== | ||
==[[Progressive multifocal leukoencephalopathy epidemiology and demographics|Epidemiology | ==[[Progressive multifocal leukoencephalopathy causes|Causes]]== | ||
==[[Progressive multifocal leukoencephalopathy differential diagnosis|Differentiating Progressive multifocal leukoencephalopathy from other Diseases]]== | |||
==[[Progressive multifocal leukoencephalopathy epidemiology and demographics|Epidemiology and Demographics]]== | |||
==[[Progressive multifocal leukoencephalopathy risk factors|Risk Factors]]== | ==[[Progressive multifocal leukoencephalopathy risk factors|Risk Factors]]== | ||
==[[Progressive multifocal leukoencephalopathy | ==[[Progressive multifocal leukoencephalopathy natural history|Natural History, Complications and Prognosis]]== | ||
Patients with Progressive Multifocal leukoencephalopathy(PML) have a long-term neurological sequelae and is often fatal. The mortality rate is 30%-50% <sup>[1]</sup> in early months of diagnosis. | |||
== | Those who are immunocompromised are at significant risk of reactivation. | ||
===== '''COMPLICATIONS''' ===== | |||
PML may complicate into the following : | |||
* Neurologic Dysfunction | |||
* Dementia | |||
* Blindness | |||
* Seizures | |||
==[[ | ===== '''PROGNOSIS''' ===== | ||
* The prognosis is variable and depends on the underlying severity of PML. | |||
* Impairment of immune system (eg. HIV) or use of immunosuppressants may worsen prognosis and leads to rapid progression of the disease.<sup>[1]</sup> | |||
* Patients who survive have substantial morbidity and severe neurological disabilities.<sup>[2]</sup> | |||
==[ | == Reference == | ||
# [https://www.ninds.nih.gov/disorders/all-disorders/progressive-multifocal-leukoencephalopathy-information-page Progressive Multifocal Leukoencephalopathy Information Page]. NIH-National Institute of Neurological Disorders and Stroke. 29 July 2019. Retrieved 12 June 2021. | |||
# Castle, D., & Robertson, N. P. (2019). Treatment of progressive multifocal leukoencephalopathy. Journal of Neurology, 266(10), 2587–2589. https://doi.org/10.1007/s00415-019-09501-y | |||
==[[Progressive multifocal leukoencephalopathy diagnosis|Diagnosis]]== | ==[[Progressive multifocal leukoencephalopathy diagnosis|Diagnosis]]== | ||
[[Progressive multifocal leukoencephalopathy history and symptoms|History | [[Progressive multifocal leukoencephalopathy history and symptoms|History and Symptoms]] | [[Progressive multifocal leukoencephalopathy physical examination|Physical Examination]] | [[Progressive multifocal leukoencephalopathy laboratory tests|Laboratory Findings]] | [[Progressive multifocal leukoencephalopathy x ray|X Ray]] | [[Progressive multifocal leukoencephalopathy CT|CT]] | [[Progressive multifocal leukoencephalopathy MRI|MRI]] | [[Progressive multifocal leukoencephalopathy echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Progressive multifocal leukoencephalopathy other imaging findings|Other Imaging Findings]] | [[Progressive multifocal leukoencephalopathy other diagnostic studies|Other Diagnostic Studies]] | ||
==Treatment== | ==Treatment== | ||
[[Progressive multifocal leukoencephalopathy medical therapy|Medical Therapy]] | [[Progressive multifocal leukoencephalopathy surgery|Surgery]] | [[Progressive multifocal leukoencephalopathy | [[Progressive multifocal leukoencephalopathy medical therapy|Medical Therapy]] | [[Progressive multifocal leukoencephalopathy surgery|Surgery]] | [[Progressive multifocal leukoencephalopathy prevention|Prevention]] | [[Progressive multifocal leukoencephalopathy cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Progressive multifocal leukoencephalopathy future or investigational therapies|Future or Investigational Therapies]] | ||
== | ==Case Studies== | ||
[[Progressive multifocal leukoencephalopathy case study one|Case #1]] | |||
== Related Chapters == | |||
* [[Leukoencephalopathy with vanishing white matter]] | * [[Leukoencephalopathy with vanishing white matter]] | ||
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[[Category:Mental disorders due to a general medical condition]] | [[Category:Mental disorders due to a general medical condition]] | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Latest revision as of 14:19, 12 June 2021
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Progressive multifocal leukoencephalopathy Microchapters |
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Differentiating Progressive multifocal leukoencephalopathy from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Progressive multifocal leukoencephalopathy On the Web |
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American Roentgen Ray Society Images of Progressive multifocal leukoencephalopathy |
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Risk calculators and risk factors for Progressive multifocal leukoencephalopathy |
This page is about clinical aspects of the disease. For microbiologic aspects of the causative organism(s), see JC virus.
For patient information click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Progressive multifocal leucoencephalopathy, Multifocal leucoencephalopathy, Multifocal leukoencephalopathy, PML, PMLE
Overview
Historical Perspective
Pathophysiology
Causes
Differentiating Progressive multifocal leukoencephalopathy from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Patients with Progressive Multifocal leukoencephalopathy(PML) have a long-term neurological sequelae and is often fatal. The mortality rate is 30%-50% [1] in early months of diagnosis. Those who are immunocompromised are at significant risk of reactivation.
COMPLICATIONS
PML may complicate into the following :
- Neurologic Dysfunction
- Dementia
- Blindness
- Seizures
PROGNOSIS
- The prognosis is variable and depends on the underlying severity of PML.
- Impairment of immune system (eg. HIV) or use of immunosuppressants may worsen prognosis and leads to rapid progression of the disease.[1]
- Patients who survive have substantial morbidity and severe neurological disabilities.[2]
Reference
- Progressive Multifocal Leukoencephalopathy Information Page. NIH-National Institute of Neurological Disorders and Stroke. 29 July 2019. Retrieved 12 June 2021.
- Castle, D., & Robertson, N. P. (2019). Treatment of progressive multifocal leukoencephalopathy. Journal of Neurology, 266(10), 2587–2589. https://doi.org/10.1007/s00415-019-09501-y
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies
Related Chapters
Template:Viral diseases de:Progressive multifokale Leukenzephalopathie nl:Progressieve multifocale leukoencefalopathie