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| {{AE}} Henry A. Hoff
| | #REDIRECT [[Forkhead box gene transcriptions]] |
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| "Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional regulators, which control a wide spectrum of biological processes."<ref name=Myatt>{{ cite journal
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| |author=Stephen S. Myatt & Eric W. -F. Lam
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| |title=The emerging roles of forkhead box (Fox) proteins in cancer
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| |journal=Nature Reviews Cancer
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| |month=November
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| |year=2007
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| |volume=7
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| |issue=
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| |pages=847-859
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| |url=http://www.nature.com/nrc/journal/v7/n11/abs/nrc2223.html
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| |arxiv=
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| |bibcode=
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| |doi=10.1038/nrc2223
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| |pmid=
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| |accessdate=2017-02-13 }}</ref>
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| ==Deregulations==
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| The "deregulation of Fox family transcription factors has a crucial role in the development and progression of cancer".<ref name=Myatt/>
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| ==Consensus sequences==
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| "FOXA2, a member of the forkhead family of transcription factors, plays essential roles in liver development and bile acid homeostasis. [We] report a 2.8 Å co-crystal structure of the FOXA2 DNA-binding domain (FOXA2-DBD) bound to a DNA duplex containing a forkhead consensus binding site (GTAAACA)."<ref name=Li>{{ cite journal
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| |author=Jun Li, Ana Carolina Dantas Machado, Ming Guo, Jared M. Sagendorf, Zhan Zhou, Longying Jiang, Xiaojuan Chen, Daichao Wu, Lingzhi Qu, Zhuchu Chen, Lin Chen, Remo Rohs, and Yongheng Chen
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| |title=Structure of the forkhead domain of FOXA2 bound to a complete DNA consensus site
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| |journal=Biochemistry
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| |date=25 July 2017
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| |volume=56
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| |issue=29
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| |pages=3745-3753
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| |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614898/
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| |arxiv=
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| |bibcode=
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| |doi=10.1021/acs.biochem.7b00211
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| |pmid=28644006
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| |accessdate=28 August 2020 }}</ref>
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| "Most paralogous FOX proteins bind to the canonical DNA response element 5′-RYAAAYA-3′ (R = A or G, Y = C or T)<sup>11–13</sup>."<ref name=Li/>
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| "Genome-wide analysis of FOXA2-binding sites by ChIP-seq in human and mouse adult liver tissues suggested that FOXA2 binds to the consensus sequence (5′-GTAAACA-3′) of the FOX family<sup>24–25</sup>."<ref name=Li/>
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| ==Acknowledgements==
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| The content on this page was first contributed by: Henry A. Hoff.
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| Initial content for this page in some instances came from [http://www.wikiversity.org Wikiversity].
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| ==See also==
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| {{div col|colwidth=20em}}
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| * [[Complex locus A1BG and ZNF497]]
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| {{Div col end}}
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| ==References==
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| {{reflist|2}}
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| ==External links==
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| <!-- footer templates -->
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| {{Gene project}}{{Sisterlinks|Forkhead boxes}}
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| <!-- footer categories -->
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| [[Category:Gene project/Lectures]]
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| [[Category:Resources last modified in August 2020]]
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