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{{Autoimmune lymphoproliferative syndrome}}
{{Autoimmune lymphoproliferative syndrome}}
{{CMG}}
{{CMG}} {{AE}}{{SharmiB}}
 
==Overview==
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== Overview ==
The [[histopathologic]] study may be helpful in the [[diagnosis]] of [[Autoimmune lymphoproliferative syndrome]]([[ALPS]]). Findings suggestive of [[ALPS]] include paracortical expansion due to infiltration of [[polyclonal]] [[TCR]] α/β+ [[DNT]] [[cells]], follicular [[hyperplasia]], and [[polyclonal]] [[plasmacytosis]].


==Other Diagnostic Studies==
==Other Diagnostic Studies==
[[Histopathological]] study findings can be helpful to [[diagnose]] [[Autoimmune lymphoproliferative syndrome]]. The findings are
* Paracortical expansion with infiltration of [[polyclonal]] [[TCR]] α/β+ [[DNT]] [[cells]].<ref name="LiHuang2015">{{cite journal|last1=Li|first1=Pu|last2=Huang|first2=Ping|last3=Yang|first3=Ye|last4=Hao|first4=Mu|last5=Peng|first5=Hongwei|last6=Li|first6=Fei|title=Updated Understanding of Autoimmune Lymphoproliferative Syndrome (ALPS)|journal=Clinical Reviews in Allergy & Immunology|volume=50|issue=1|year=2015|pages=55–63|issn=1080-0549|doi=10.1007/s12016-015-8466-y}}</ref>
* [[DNT]] [[cells]] express TIA-1 and CD57, CD45RO negative
* Follicular [[hyperplasia]]
* Polyclonal [[plasmacytosis]]
* [[Spleen]] has expanded [[T cell]] areas dominated by [[DNT]] [[cells]].


==References==
==References==
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[[Category:Hematology]]
[[Category:Hematology]]
{{WH}}
{{WS}}

Latest revision as of 04:12, 6 August 2021

Autoimmune lymphoproliferative syndrome Microchapters

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