Cardiac tumors causes: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Cardiac tumors}} | {{Cardiac tumors}} | ||
{{CMG}} | {{CMG}}; {{AE}} {{DMakkar}} | ||
==Overview== | ==Overview== | ||
* Numerous genetic disorders are associated with cardiac tumors however, till now no direct causes have been identified. | |||
==Causes== | ==Causes== | ||
*Many genetic conditions are strongly associated with a large number of heart tumors. Some of them are as follows:<ref name="pmid29214333">{{cite journal| author=Lee E, Mahani MG, Lu JC, Dorfman AL, Srinivasan A, Agarwal PP| title=Primary cardiac tumors associated with genetic syndromes: a comprehensive review. | journal=Pediatr Radiol | year= 2018 | volume= 48 | issue= 2 | pages= 156-164 | pmid=29214333 | doi=10.1007/s00247-017-4027-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29214333 }} </ref> | |||
{| class="wikitable" | |||
|+ Cardiac tumors genetic causes | |||
|- | |||
! Tumor !! Syndrome !! Gene Associated with syndrome | |||
|- | |||
| [[Rhabdomyoma]] || [[Tuberous Sclerosis]] || TSC1 or hamartin | |||
TSC2 or tuberin | |||
|- | |||
| [[Fibroma]] || [[Gorlin Syndrome]] || PATCHED gene | |||
|- | |||
| [[Myxoma]] || [[Carney Complex]] || Inactivating mutation of PRKARA1A | |||
Activating pathogenic variant of PRKACA gene | |||
|- | |||
| [[Paraganglioma]]|| [[Carney triad]]|| No known gene associations | |||
|- | |||
| [[Paraganglioma]] || [[Hereditary Paraganglioma]] || Mutation of succinate dehydrogenase subunit | |||
SDHAF2 gene, and possibly MAX gene but these mutations are rare | |||
|- | |||
| [[Paraganglioma]] || [[Von Hippel Lindau]] || VHL gene | |||
|- | |||
| [[Paraganglioma]] || [[Neurofibromatosis type 1]] || NF1 gene | |||
|} | |||
==References== | ==References== | ||
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{{WS}} | {{WS}} | ||
[[Category: | |||
[[Category:Up to Date]] | |||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Cardiology]] | [[Category:Cardiology]] | ||
Latest revision as of 16:26, 14 July 2022
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Cardiac tumors causes On the Web |
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American Roentgen Ray Society Images of Cardiac tumors causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dheeraj Makkar, M.D.[2]
Overview
- Numerous genetic disorders are associated with cardiac tumors however, till now no direct causes have been identified.
Causes
- Many genetic conditions are strongly associated with a large number of heart tumors. Some of them are as follows:[1]
| Tumor | Syndrome | Gene Associated with syndrome |
|---|---|---|
| Rhabdomyoma | Tuberous Sclerosis | TSC1 or hamartin
TSC2 or tuberin |
| Fibroma | Gorlin Syndrome | PATCHED gene |
| Myxoma | Carney Complex | Inactivating mutation of PRKARA1A
Activating pathogenic variant of PRKACA gene |
| Paraganglioma | Carney triad | No known gene associations |
| Paraganglioma | Hereditary Paraganglioma | Mutation of succinate dehydrogenase subunit
SDHAF2 gene, and possibly MAX gene but these mutations are rare |
| Paraganglioma | Von Hippel Lindau | VHL gene |
| Paraganglioma | Neurofibromatosis type 1 | NF1 gene |
References
- ↑ Lee E, Mahani MG, Lu JC, Dorfman AL, Srinivasan A, Agarwal PP (2018). "Primary cardiac tumors associated with genetic syndromes: a comprehensive review". Pediatr Radiol. 48 (2): 156–164. doi:10.1007/s00247-017-4027-2. PMID 29214333.