|
|
| Line 2: |
Line 2: |
| {{CMG}} | | {{CMG}} |
|
| |
|
| ==Statin Therapy==
| |
| ===Drug Interactions===
| |
| *[[Cyclosporin]] co-administration is associated with a higher rate of [[myositis]] among statin users as a result of inhibition of [[CYP3A4]]. The exception is [[pravastatin]] in which this is not a problem.
| |
| ===Myositis===
| |
| * The risk of [[myositis]] is lowest with [[pravastatin]] and is not improved with switching to [[atorvastatin]]. [[Simvastatin]] at a dose of 80 mg is associated with a particularly high incidence of myositis.
| |
|
| |
| ===Reducing non-myositis Muscle Pain===
| |
| * [[Coenzyme Q]] can be used to reduce the incidence of non-[[myositis]] muscle pain. Several weeks of coenzyme Q should be administered prior to trying the combination of the agent with statin therapy.
| |
|
| |
|
| ==References== | | ==References== |
Latest revision as of 00:52, 4 November 2011