Papular purpuric gloves and socks syndrome: Difference between revisions

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==Causes==
==Causes==
* An association with [[parvovirus B19]] has been described.<ref name="pmid18808380">{{cite journal |author=Fölster-Holst R, Kreth HW|title=Viral exanthems in childhood--infectious (direct) exanthems. Part 2: Other viral exanthems |journal=J Dtsch Dermatol Ges |volume=7|issue=5 |pages=414–9 |year=2009 |month=May |pmid=18808380 |doi=10.1111/j.1610-0387.2008.06869.x }}</ref>  
* An association with [[parvovirus B19]] has been described.<ref name="pmid18808380">{{cite journal |author=Fölster-Holst  
 
R, Kreth HW|title=Viral exanthems in childhood--infectious (direct) exanthems. Part 2: Other viral exanthems |journal=J  
 
Dtsch Dermatol Ges |volume=7|issue=5 |pages=414–9 |year=2009 |month=May |pmid=18808380 |doi=10.1111/j.1610-
 
0387.2008.06869.x }}</ref>  
* The syndrome has also been associated with several viruses such as [[HHV]]6, [[measles]] and [[coxsackie]] B6


==Epidemiology and Demographics==
==Epidemiology and Demographics==
* PPGSS occurs primarily in teenagers and young adults.  
* PPGSS occurs primarily in teenagers and young adults.  
==Natural History, Complications and Prognosis==
* [[Rash]] and [[fever]] completely resolved in less than 3 days.
* The disease has a short course and a benign prognosis.


==Diagnosis==
==Diagnosis==
Line 23: Line 34:
====Extremities====
====Extremities====
* [[Edema]]  
* [[Edema]]  
* [[Erythema]] of the hands and feet, <ref name="Andrews">{{cite book |author=James, William D.; Berger, Timothy G.; et al. |title=Andrews' Diseases of the Skin: clinical Dermatology |publisher=Saunders Elsevier |location= |year=2006 |pages= |isbn=0-7216-2921-0 |oclc= |doi=|accessdate=}}</ref>  
* [[Erythema]] of the hands and feet, <ref name="Andrews">{{cite book |author=James, William D.; Berger, Timothy G.; et  
 
al. |title=Andrews' Diseases of the Skin: clinical Dermatology |publisher=Saunders Elsevier |location= |year=2006 |pages=  
 
|isbn=0-7216-2921-0 |oclc= |doi=|accessdate=}}</ref>  


===Laboratory Findings===
===Laboratory Findings===
* Positive serology for [[Parvovirus B19]].
* All laboratory tests are normal.
* Positive serology for [[Parvovirus B19]]. IgM is positive but not IgG.<ref name="pmid19129008">{{cite journal |
author=Parez N, Dehée A, Michel Y, Veinberg F, Garbarg-Chenon A |title=Papular-purpuric gloves and socks syndrome
associated with B19V infection in a 6-year-old child |journal=J. Clin. Virol. |volume=44 |issue=2 |pages=167–9 |year=2009
|month=February |pmid=19129008 |doi=10.1016/j.jcv.2008.11.013 |url=}}</ref>
* Viral DNA test to detect the [[virus]].


== References ==
== References ==

Latest revision as of 17:55, 1 August 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Synonyms and keywords: PPGSS

Overview

Papular purpuric gloves and socks syndrome (PPGSS) is an uncommon cutaneous condition with a typical purpuric exanthem limited to hands and feet.

Causes

Epidemiology and Demographics

  • PPGSS occurs primarily in teenagers and young adults.

Natural History, Complications and Prognosis

  • Rash and fever completely resolved in less than 3 days.
  • The disease has a short course and a benign prognosis.

Diagnosis

Symptoms

PPGSS is characterized by

Physical Examination

Extremities

Laboratory Findings

  • All laboratory tests are normal.
  • Positive serology for Parvovirus B19. IgM is positive but not IgG.[3]
  • Viral DNA test to detect the virus.

References

  1. Fölster-Holst R, Kreth HW (2009). "Viral exanthems in childhood--infectious (direct) exanthems. Part 2: Other viral exanthems". J Dtsch Dermatol Ges. 7 (5): 414–9. doi:[//doi.org/10.1111%2Fj.1610-%0A%0A0387.2008.06869.x 10.1111/j.1610- 0387.2008.06869.x] Check |doi= value (help). PMID 18808380. Unknown parameter |month= ignored (help); line feed character in |author= at position 15 (help); line feed character in |journal= at position 3 (help); line feed character in |doi= at position 16 (help)
  2. James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. line feed character in |author= at position 43 (help)
  3. Parez N, Dehée A, Michel Y, Veinberg F, Garbarg-Chenon A (2009). "Papular-purpuric gloves and socks syndrome associated with B19V infection in a 6-year-old child". J. Clin. Virol. 44 (2): 167–9. doi:10.1016/j.jcv.2008.11.013. PMID 19129008. Unknown parameter |month= ignored (help); line feed character in |title= at position 44 (help)


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