Anti-citrullinated protein antibody: Difference between revisions
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'''Anti-citrullinated protein antibodies''' (ACPA) or '''anti-cyclic citrullinated protein antibodies''' (anti-CCP) are [[autoantibody|autoantibodies]] (antibodies against human tissues) frequently detected in [[rheumatoid arthritis]]. The main [[epitope]] for these antibodies is [[filaggrin]], and there is cross-reactivity between ACPA and anti-keratin and anti-perinuclear factor.<ref>{{cite journal |author=Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ |title=Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies |journal=J. Clin. Invest. |volume=101 |issue=1 |pages=273–81 |year=1998 |month=January |pmid=9421490 |doi=10.1172/JCI1316 |url=http://www.jci.org/articles/view/1316}} {{PMC|508564}}</ref> In a comparative study, various detection kits had a [[sensitivity (test)|sensitivity]] between 69.6% and 77.5% and a specificity between 87.8% and 96.4%.<ref>{{cite journal |author=Coenen D, Verschueren P, Westhovens R, Bossuyt X |title=Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis |journal=Clin. Chem. |volume=53 |issue=3 |pages=498–504 |year=2007 |month=March |pmid=17259232 |doi=10.1373/clinchem.2006.078063 |url=http://www.clinchem.org/cgi/content/full/53/3/498}}</ref> Given that ACPA is more specific than [[rheumatoid factor]], it is used to distinguish various causes of arthritis.<ref>{{cite journal |author=Avouac J, Gossec L, Dougados M |title=Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review |journal=Ann. Rheum. Dis. |volume=65 |issue=7 |pages=845–51 |year=2006 |month=July |pmid=16606649 |doi=10.1136/ard.2006.051391 |url=http://ard.bmj.com/cgi/content/full/65/7/845}}</ref> | '''Anti-citrullinated protein antibodies''' (ACPA) or '''anti-cyclic citrullinated protein antibodies''' (anti-CCP) are [[autoantibody|autoantibodies]] (antibodies against human tissues) frequently detected in [[rheumatoid arthritis]]. The main [[epitope]] for these antibodies is [[filaggrin]], and there is cross-reactivity between ACPA and anti-keratin and anti-perinuclear factor.<ref>{{cite journal |author=Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ |title=Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies |journal=J. Clin. Invest. |volume=101 |issue=1 |pages=273–81 |year=1998 |month=January |pmid=9421490 |doi=10.1172/JCI1316 |url=http://www.jci.org/articles/view/1316}} {{PMC|508564}}</ref> In a comparative study, various detection kits had a [[sensitivity (test)|sensitivity]] between 69.6% and 77.5% and a specificity between 87.8% and 96.4%.<ref>{{cite journal |author=Coenen D, Verschueren P, Westhovens R, Bossuyt X |title=Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis |journal=Clin. Chem. |volume=53 |issue=3 |pages=498–504 |year=2007 |month=March |pmid=17259232 |doi=10.1373/clinchem.2006.078063 |url=http://www.clinchem.org/cgi/content/full/53/3/498}}</ref> Given that ACPA is more specific than [[rheumatoid factor]], it is used to distinguish various causes of arthritis.<ref>{{cite journal |author=Avouac J, Gossec L, Dougados M |title=Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review |journal=Ann. Rheum. Dis. |volume=65 |issue=7 |pages=845–51 |year=2006 |month=July |pmid=16606649 |doi=10.1136/ard.2006.051391 |url=http://ard.bmj.com/cgi/content/full/65/7/845}}</ref> | ||
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{{Autoantibodies}} | {{Autoantibodies}} | ||
[[Category:Blood | [[Category:Blood tests]] | ||
[[Category:Rheumatology]] | [[Category:Rheumatology]] | ||
[[Category:Autoantibodies|C]] | [[Category:Autoantibodies|C]] | ||
Latest revision as of 22:18, 8 August 2012
| Anti-citrullinated protein antibody |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Anti-citrullinated protein antibodies (ACPA) or anti-cyclic citrullinated protein antibodies (anti-CCP) are autoantibodies (antibodies against human tissues) frequently detected in rheumatoid arthritis. The main epitope for these antibodies is filaggrin, and there is cross-reactivity between ACPA and anti-keratin and anti-perinuclear factor.[1] In a comparative study, various detection kits had a sensitivity between 69.6% and 77.5% and a specificity between 87.8% and 96.4%.[2] Given that ACPA is more specific than rheumatoid factor, it is used to distinguish various causes of arthritis.[3]
References
- ↑ Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ (1998). "Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies". J. Clin. Invest. 101 (1): 273–81. doi:10.1172/JCI1316. PMID 9421490. Unknown parameter
|month=ignored (help) PMC 508564 - ↑ Coenen D, Verschueren P, Westhovens R, Bossuyt X (2007). "Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis". Clin. Chem. 53 (3): 498–504. doi:10.1373/clinchem.2006.078063. PMID 17259232. Unknown parameter
|month=ignored (help) - ↑ Avouac J, Gossec L, Dougados M (2006). "Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review". Ann. Rheum. Dis. 65 (7): 845–51. doi:10.1136/ard.2006.051391. PMID 16606649. Unknown parameter
|month=ignored (help)