Ascofuranone: Difference between revisions
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'''Ascofuranone''' is an [[antibiotic]] that inhibits the ''[[Trypanosoma brucei]]'' [[alternative oxidase]] and is a lead compound in efforts to produce other drugs targeting this enzyme for the treatment of [[sleeping sickness]].<ref>{{cite journal |author=Minagawa N, Yabu Y, Kita K, Nagai K, Ohta N, Meguro K, Sakajo S, Yoshimoto A |title=An antibiotic, ascofuranone, specifically inhibits respiration and in vitro growth of long slender bloodstream forms of Trypanosoma brucei brucei |journal=Mol. Biochem. Parasitol. |volume=84 |issue=2 |pages=271-80 |year=1997 |pmid=9084049}}</ref> The compound is effective both in vitro [[cell culture]] and in infections in mice.<ref>{{cite journal |author=Yabu Y, Yoshida A, Suzuki T, Nihei C, Kawai K, Minagawa N, Hosokawa T, Nagai K, Kita K, Ohta N |title=The efficacy of ascofuranone in a consecutive treatment on Trypanosoma brucei brucei in mice |journal=Parasitol. Int. |volume=52 |issue=2 |pages=155-64 |year=2003 |pmid=12798927}}</ref> | '''Ascofuranone''' is an [[antibiotic]] that inhibits the ''[[Trypanosoma brucei]]'' [[alternative oxidase]] and is a lead compound in efforts to produce other drugs targeting this enzyme for the treatment of [[sleeping sickness]].<ref>{{cite journal |author=Minagawa N, Yabu Y, Kita K, Nagai K, Ohta N, Meguro K, Sakajo S, Yoshimoto A |title=An antibiotic, ascofuranone, specifically inhibits respiration and in vitro growth of long slender bloodstream forms of Trypanosoma brucei brucei |journal=Mol. Biochem. Parasitol. |volume=84 |issue=2 |pages=271-80 |year=1997 |pmid=9084049}}</ref> The compound is effective both in vitro [[cell culture]] and in infections in mice.<ref>{{cite journal |author=Yabu Y, Yoshida A, Suzuki T, Nihei C, Kawai K, Minagawa N, Hosokawa T, Nagai K, Kita K, Ohta N |title=The efficacy of ascofuranone in a consecutive treatment on Trypanosoma brucei brucei in mice |journal=Parasitol. Int. |volume=52 |issue=2 |pages=155-64 |year=2003 |pmid=12798927}}</ref> | ||
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Ascofuranone is an antibiotic that inhibits the Trypanosoma brucei alternative oxidase and is a lead compound in efforts to produce other drugs targeting this enzyme for the treatment of sleeping sickness.[1] The compound is effective both in vitro cell culture and in infections in mice.[2]
Ascofuranone has also been reported to have anti-tumor activity,[3] and modulate the immune system.[4]
References
- ↑ Minagawa N, Yabu Y, Kita K, Nagai K, Ohta N, Meguro K, Sakajo S, Yoshimoto A (1997). "An antibiotic, ascofuranone, specifically inhibits respiration and in vitro growth of long slender bloodstream forms of Trypanosoma brucei brucei". Mol. Biochem. Parasitol. 84 (2): 271–80. PMID 9084049.
- ↑ Yabu Y, Yoshida A, Suzuki T, Nihei C, Kawai K, Minagawa N, Hosokawa T, Nagai K, Kita K, Ohta N (2003). "The efficacy of ascofuranone in a consecutive treatment on Trypanosoma brucei brucei in mice". Parasitol. Int. 52 (2): 155–64. PMID 12798927.
- ↑ Magae J, Hayasaki J, Matsuda Y, Hotta M, Hosokawa T, Suzuki S, Nagai K, Ando K, Tamura G (1988). "Antitumor and antimetastatic activity of an antibiotic, ascofuranone, and activation of phagocytes". J. Antibiot. 41 (7): 959–65. PMID 3417568.
- ↑ Magae J, Suzuki S, Nagai K, Yamasaki M, Ando K, Tamura G (1986). "In vitro effects of an antitumor antibiotic, ascofuranone, on the murine immune system". Cancer Res. 46 (3): 1073–8. PMID 3080231.