Beta thalassemia cardiomyopathy: Difference between revisions
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New page: {{SI}} {{CMG}} {{EH}} Untreated thalassemia Major eventually leads to death usually by heart failure, therefore birth screening is very important. β-Thalassemia cardiomyopathy take... |
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Untreated thalassemia Major eventually leads to death usually by [[heart failure]], therefore birth screening is very important. β-Thalassemia cardiomyopathy takes on two phenotypes: | Untreated thalassemia Major eventually leads to death usually by [[heart failure]], therefore birth screening is very important. β-Thalassemia cardiomyopathy takes on two phenotypes: | ||
Latest revision as of 22:53, 8 August 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Untreated thalassemia Major eventually leads to death usually by heart failure, therefore birth screening is very important. β-Thalassemia cardiomyopathy takes on two phenotypes:
- Dilated phenotype: Left ventricular dilatation and impaired contractility are present
- Restrictive phenotype: Restrictive left ventricular filling is present along with pulmonary hypertension, and right heart failure.
The pathophysiology of β-Thalassemia cardiomyopathy is multifactorial, with myocardial iron overload and immunoinflammatory processes being the predominant mechanisms.