Café au lait spot: Difference between revisions
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'''Associate Editor-In-Chief:''' {{CZ}} | '''Associate Editor-In-Chief:''' {{CZ}} | ||
'''Café au lait spots''' or '''cafe-au-lait spots''' (CAL) are pigmented [[birthmark]]s. | '''Café au lait spots''' or '''cafe-au-lait spots''' (CAL) are pigmented [[birthmark]]s. | ||
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Also, having six or more of such spots greater than 5 mm in diameter prepubertal or greater than 15 mm in diameter postpubertal children is a cardinal diagnostic feature of [[Neurofibromatosis type I]]. | Also, having six or more of such spots greater than 5 mm in diameter prepubertal or greater than 15 mm in diameter postpubertal children is a cardinal diagnostic feature of [[Neurofibromatosis type I]]. | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
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* [[Maffucci syndrome]] | * [[Maffucci syndrome]] | ||
* [[Multiple mucosal neuroma syndrome]] ([[Multiple endocrine neoplasia type 2]]) | * [[Multiple mucosal neuroma syndrome]] ([[Multiple endocrine neoplasia type 2]]) | ||
== Diagnosis == | |||
=== Physical Examination === | |||
====Skin==== | |||
<div align="left"> | |||
<gallery heights="175" widths="175"> | |||
Image:cafe au lait (NFT1 or NFT2).jpg|Cafe au lait spot<ref>http://picasaweb.google.com/mcmumbi/USMLEIIImages</ref> | |||
Image:cafe au lait (with MR, it's McCune Albright).jpg|Cafe au lait spot (with MR, it's McCune Albright)<ref>http://picasaweb.google.com/mcmumbi/USMLEIIImages</ref> | |||
</gallery> | |||
</div> | |||
==See also== | ==See also== | ||
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{{Diseases of the skin and subcutaneous tissue}} | {{Diseases of the skin and subcutaneous tissue}} | ||
<br> | <br> | ||
[[de:Café-au-lait-Fleck]] | [[de:Café-au-lait-Fleck]] | ||
Latest revision as of 23:21, 8 August 2012
| Café au lait spot | |
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| A café au lait spot on a patient's left cheek. | |
| ICD-10 | L81.3 |
| ICD-9 | 709.09 |
| DiseasesDB | 16118 |
| eMedicine | ped/2754 |
| MeSH | D019080 |
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WikiDoc Resources for Café au lait spot |
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Most recent articles on Café au lait spot Most cited articles on Café au lait spot |
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Powerpoint slides on Café au lait spot |
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Evidence Based Medicine |
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Cochrane Collaboration on Café au lait spot |
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Clinical Trials |
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Ongoing Trials on Café au lait spot at Clinical Trials.gov Trial results on Café au lait spot Clinical Trials on Café au lait spot at Google
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US National Guidelines Clearinghouse on Café au lait spot NICE Guidance on Café au lait spot
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Definitions |
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Patient Resources / Community |
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Patient resources on Café au lait spot Discussion groups on Café au lait spot Patient Handouts on Café au lait spot Directions to Hospitals Treating Café au lait spot Risk calculators and risk factors for Café au lait spot
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Causes & Risk Factors for Café au lait spot |
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Continuing Medical Education (CME) |
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Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Café au lait spots or cafe-au-lait spots (CAL) are pigmented birthmarks.
Etymology
The name café au lait is French for "coffee with milk" and refers to their light-brown color in persons with light skin. It will appear as a darker lesion café noir in people with dark skin.
Pathophysiology
While café au lait spots are usually not associated with any medical problems, having many (three or more) such spots is linked with neurofibromatosis and the rare McCune-Albright syndrome.
Also, having six or more of such spots greater than 5 mm in diameter prepubertal or greater than 15 mm in diameter postpubertal children is a cardinal diagnostic feature of Neurofibromatosis type I.
Differential Diagnosis
Other syndromes that may include Cafe au lait spots:
- Fanconi anemia
- Tuberous sclerosis
- Russell-Silver syndrome (Silver-Russell dwarfism)
- Ataxia telangiectasia
- Bloom syndrome
- Basal cell nevus syndrome
- Gaucher disease
- Chédiak-Higashi syndrome
- Hunter syndrome
- Maffucci syndrome
- Multiple mucosal neuroma syndrome (Multiple endocrine neoplasia type 2)
Diagnosis
Physical Examination
Skin
![Cafe au lait spot[1]](/index.php/File:Cafe_au_lait_(NFT1_or_NFT2).jpg)
![Cafe au lait spot (with MR, it's McCune Albright)[2]](/index.php/File:Cafe_au_lait_(with_MR,_it%27s_McCune_Albright).jpg)
