Juvenile myelomonocytic leukemia pathophysiology: Difference between revisions
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== Genetics == | |||
About 80% of JMML patients have some sort of genetic abnormality in their leukemia cells that can be identified with laboratory testing. This includes: | |||
*15-20% of patients with [[neurofibromatosis 1]] (NF1) | |||
*25% of patients with mutations in one of the [[Ras (protein)|RAS]] family of [[oncogene]]s (only in their leukemia cells) | |||
*Another 35% of patients with a mutation in a gene called [[PTPN11]] (again, only in their leukemia cells). | |||
==References== | ==References== | ||
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{{Hematological malignancy histology}} | {{Hematological malignancy histology}} | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
Latest revision as of 16:39, 9 August 2012
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Juvenile myelomonocytic leukemia Microchapters |
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Differentiating Juvenile myelomonocytic leukemia from other Diseases |
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Diagnosis |
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Treatment |
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Juvenile myelomonocytic leukemia pathophysiology On the Web |
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Juvenile myelomonocytic leukemia pathophysiology in the news |
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Risk calculators and risk factors for Juvenile myelomonocytic leukemia pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Genetics
About 80% of JMML patients have some sort of genetic abnormality in their leukemia cells that can be identified with laboratory testing. This includes:
- 15-20% of patients with neurofibromatosis 1 (NF1)
- 25% of patients with mutations in one of the RAS family of oncogenes (only in their leukemia cells)
- Another 35% of patients with a mutation in a gene called PTPN11 (again, only in their leukemia cells).