Markers of invasive fungal infection: Difference between revisions
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'''Editor-in-Chief:''' Alexandra Bailey, M.D., Beth Israel Deaconess Medical Center, Harvard Medical School, Boston Massachusetts, [mailto:asbailey@bidmc.harvard.edu] | '''Editor-in-Chief:''' Alexandra Bailey, M.D., Beth Israel Deaconess Medical Center, Harvard Medical School, Boston Massachusetts, [mailto:asbailey@bidmc.harvard.edu] | ||
==Overview== | ==Overview== | ||
Beta-D-Glucan is a cell wall component of all fungi, including Pneumocystis jirovecii (PCP), Candida species and Aspergillus. In the serum test, a spectrophotometer is used to determine optical density and beta-D-glucan concentrations are interpreted as negative (range <60 pg/mL), indeterminate (60 to 79 pg/mL), or positive (>80 pg/mL). | Beta-D-Glucan is a cell wall component of all fungi, including [[Pneumocystis jirovecii]] ([[PCP]]), [[Candida]] species and [[Aspergillus]]. In the serum test, a spectrophotometer is used to determine optical density and beta-D-glucan concentrations are interpreted as negative (range <60 pg/mL), indeterminate (60 to 79 pg/mL), or positive (>80 pg/mL). | ||
Galactomannin, which is released during growth of hyphae, is a major constituent of Aspergillus cell walls. Early detection of serum galactomannan by sandwich enzyme-linked immunosorbent assay (ELISA) has been explored by a number of groups as a diagnostic test for invasive aspergillosis. | [[Galactomannin]], which is released during growth of hyphae, is a major constituent of [[Aspergillus]] cell walls. Early detection of serum galactomannan by sandwich enzyme-linked immunosorbent assay ([[ELISA]]) has been explored by a number of groups as a diagnostic test for invasive aspergillosis. | ||
==Sensitivity== | ==Sensitivity== | ||
Latest revision as of 17:11, 9 August 2012
Editor-in-Chief: Alexandra Bailey, M.D., Beth Israel Deaconess Medical Center, Harvard Medical School, Boston Massachusetts, [1]
Overview
Beta-D-Glucan is a cell wall component of all fungi, including Pneumocystis jirovecii (PCP), Candida species and Aspergillus. In the serum test, a spectrophotometer is used to determine optical density and beta-D-glucan concentrations are interpreted as negative (range <60 pg/mL), indeterminate (60 to 79 pg/mL), or positive (>80 pg/mL).
Galactomannin, which is released during growth of hyphae, is a major constituent of Aspergillus cell walls. Early detection of serum galactomannan by sandwich enzyme-linked immunosorbent assay (ELISA) has been explored by a number of groups as a diagnostic test for invasive aspergillosis.