Nephrotoxic drugs: Difference between revisions

	WikiDoc Resources for Nephrotoxic drugs
Articles
Most recent articles on Nephrotoxic drugs Most cited articles on Nephrotoxic drugs Review articles on Nephrotoxic drugs Articles on Nephrotoxic drugs in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Nephrotoxic drugs Images of Nephrotoxic drugs Photos of Nephrotoxic drugs Podcasts & MP3s on Nephrotoxic drugs Videos on Nephrotoxic drugs
Evidence Based Medicine
Cochrane Collaboration on Nephrotoxic drugs Bandolier on Nephrotoxic drugs TRIP on Nephrotoxic drugs
Clinical Trials
Ongoing Trials on Nephrotoxic drugs at Clinical Trials.gov Trial results on Nephrotoxic drugs Clinical Trials on Nephrotoxic drugs at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Nephrotoxic drugs NICE Guidance on Nephrotoxic drugs NHS PRODIGY Guidance FDA on Nephrotoxic drugs CDC on Nephrotoxic drugs
Books
Books on Nephrotoxic drugs
News
Nephrotoxic drugs in the news Be alerted to news on Nephrotoxic drugs News trends on Nephrotoxic drugs
Commentary
Blogs on Nephrotoxic drugs
Definitions
Definitions of Nephrotoxic drugs
Patient Resources / Community
Patient resources on Nephrotoxic drugs Discussion groups on Nephrotoxic drugs Patient Handouts on Nephrotoxic drugs Directions to Hospitals Treating Nephrotoxic drugs Risk calculators and risk factors for Nephrotoxic drugs
Healthcare Provider Resources
Symptoms of Nephrotoxic drugs Causes & Risk Factors for Nephrotoxic drugs Diagnostic studies for Nephrotoxic drugs Treatment of Nephrotoxic drugs
Continuing Medical Education (CME)
CME Programs on Nephrotoxic drugs
International
Nephrotoxic drugs en Espanol Nephrotoxic drugs en Francais
Business
Nephrotoxic drugs in the Marketplace Patents on Nephrotoxic drugs
Experimental / Informatics
List of terms related to Nephrotoxic drugs

VisualWikitext

Latest revision as of 16:16, 10 August 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2], Aarti Narayan, M.B.B.S [3]

Overview

Nephrotoxic drugs are pharmacotherapies that can lead to a decline in renal function. The drug may need to be discontinued, or the dosing reduced when this happens.

Common Nephrotoxic drugs

Antibiotics

Antibacterials

Aminoglycosides (10-15% Incidence of acute tubular necrosis)

Occurs in 10-20% patients on 7 day course
Results in non-oligurics; increased creatinine
A single dose early in septic course is usually safe

Antivirals

Acyclovir (only nephrotoxic in intravenous form)
Adefovir
Cidofovir
Foscarnet
Indinavir
Tenofovir

Antiparasitic drugs

Chemotherapy and Immunosuppressants

Heavy Metals and Poisons

Arsenic poisoning
Bismuth
Gold therapy
Lead poisoning
Lithium related kidney disorders

Polydipsia and nephrogenic diabetes insipidus
Acute renal failure
- Dialysis indications: serum creatinine >2.5 or seizures, rhabdomyolysis
Chronic kidney disease with fibrosis

Mercury poisoning
Nitrosourea compounds

AntiHyperlipidemics

Fenofibrate (Tricor)

Increases serum creatinine without significant decrease in GFR
Serum creatinine rise is reversible on stopping fenofibrate

Gemfibrozil

Associated with acute renal failure due to rhabdomyolysis

Statins

Chemotherapy

Causes fanconi's syndrome

Lomustine

Proton channel blockers

Miscellaneous Drugs

Chronic stimulant laxative use

Resulting chronic volume depletion and hypokalemia causes nephropathy

Expect an increase of serum creatinine in chronic kidney disease

Low dose aspirin reduces renal function in elderly
- Decreased creatinine clearance after 2 weeks of use
- Changes persisted for at least 3 weeks off aspirin

Aristocholic acid containing Chinese herbals
Bevacizumab
Carbon tetrachloride
Cimetidine
Ciprofloxacin
Clopidogrel
Dilantin
Diuretics

Infliximab
Interferons
Mesalamine (Asacol, Pentasa)

Mesalamine is an NSAID analog and has systemic absorption from the bowel

NSAIDs: celecoxib, ibuprofen, naproxen

Nephrotic syndrome type reaction

Hypersensitivity (fever, rash, arthralgia)

Vasculitis reaction

Drugs of abuse

Nephrotoxic Drugs in Alphabetical Order

ACE Inhibitors
Acetaminophen
Acyclovir
Adefovir
Allopurinol
Aminoglycosides
Amitriptyline
Amphotericin B
Angiotensin converting enzyme inhibitors
Anticoagulants
Aristocholic acid containing Chinese herbals
Arsenic poisoning
Aspirin
Bevacizumab
Bismuth
Carbon tetrachloride
Carboplatin
Carmustine
Celecoxib
Cephalosporins
Chloroquine
Cidofovir
Cimetidine
Ciprofloxacin
Cisplatin
Clopidogrel
Cocaine
Cyclosporine
Dilantin
Diphenhydramine
Diuretics
Doxepin
Doxylamine
Erythromycin
Esomeprazole
Fenofibrate (Tricor)
Fluoxetine
Foscarnet
Furosemide
Gemfibrozil
Gentamycin
Gold therapy
H1 antagonist
Heroin
Hydroxychloroquine

References

Template:WikiDoc Sources

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{SI}}
-{{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}}
+{{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}}, {{AN}}
 ==Overview==
 Nephrotoxic drugs are pharmacotherapies that can lead to a decline in renal function.  The drug may need to be discontinued, or the dosing reduced when this happens.
+==Common Nephrotoxic drugs==
+*[[Acetaminophen]]
+*[[Aspirin]]
+*[[H1 antagonist]]
+*[[Cephalosporins]]
+*[[Cocaine]]
+*[[Diuretics]]
+*[[NSAID]]s
+*[[Penicillin]]s
+*[[Proton pump inhibitors]]
+*[[Angiotensin converting enzyme inhibitor]]s
+*[[Statins]]
 ==Antibiotics==
+===Antibacterials===
+*[[Aminoglycosides]] (10-15% Incidence of [[acute tubular necrosis]])
+:*Occurs in 10-20% patients on 7 day course
+:*Results in non-oligurics; increased [[creatinine]]
+:*A single dose early in septic course is usually safe
+*[[Amphotericin B]] (Incidence 80-90%)
+*[[Ciprofloxacin]]
+*[[Chloroquine]]
+*[[Erythromycin]]
+*[[Gentamycin]]
+*[[Hydroxychloroquine]]
+*[[Isoniazide]]
+*[[Levofloxacin]]
+*[[Methicillin]]
+*[[Rifampin]]
+*[[Sulfonamides]]
+*[[Tetracycline]]
+*[[Trimethadione]]
+*[[Vancomycin]]
+===Antivirals===
 *[[Acyclovir]] (only nephrotoxic in intravenous form)
-*[[Aminoglycosides]] (10-15% Incidence of Acute Tubular Necrosis)
+*[[Adefovir]]
-:* Occurs in 10-20% patients on 7 day course
+*[[Cidofovir]]
-:* Results in non-oligurics; increased [[Creatinine]]
+*[[Foscarnet]]
-:* A single dose early in septic course is usually safe
+*[[Indinavir]]
-* [[Amphotericin B]] (Incidence 80-90%)
+*[[Tenofovir]]
-* [[Ciprofloxacin]]
+===Antiparasitic drugs===
 *[[Chloroquine]]
-*[[Erythromycin]]
+*[[Hydroxychloroquine]]
-* [[Levofloxacin]]
+*[[Pentamidine]]
-* [[Pentamidine]]
+*[[Quinine]]
-* [[Rifampin]]
-* [[Sulfonamides]]
-* [[Tetracycline]]
 ==Chemotherapy and Immunosuppressants==
-* [[Cisplatin]]
+*[[Cisplatin]]
-* [[Cyclosporine]]
+*[[Cyclosporine]]
-* [[Methotrexate]]
+*[[Interferon alpha]]
-* [[Mitomycin]]
+*[[Methotrexate]]
+*[[Mitomycin]]
+*[[Foscarnet]]
+*[[Tacrolimus]]
-== Heavy Metals==
+== Heavy Metals and Poisons==
-* [[Arsenic]] Poisoning
+*[[Arsenic]] poisoning
-* [[Bismuth]]
+*[[Bismuth]]
-* [[Lead]] Poisoning
+*Gold therapy
-* [[Lithium]] related kidney disorders
+*[[Lead]] poisoning
-:* [[Polydipsia]] and [[Nephrogenic Diabetes Insipidus]]
+*[[Lithium]] related kidney disorders
-:* [[Acute Renal Failure]]
+:*[[Polydipsia]] and [[nephrogenic diabetes insipidus]]
-:*:* [[Dialysis]] indications: [[Creatinine]] >2.5 or [[Seizure]]s, ALOC, [[Rhabdomyolysis]]
+:*[[Acute renal failure]]
-:* [[Chronic kidney disease]] with [[fibrosis]]
+:*:*[[Dialysis]] indications: [[serum creatinine]] >2.5 or [[seizure]]s, [[rhabdomyolysis]]
-* [[Mercury]] Poisoning
+:*[[Chronic kidney disease]] with [[fibrosis]]
+*[[Mercury]] poisoning
+*[[Nitrosourea compounds]]
 ==AntiHyperlipidemics==
-* [[Fenofibrate]] (Tricor)
+*[[Fenofibrate]] (Tricor)
-:* Increases Serum [[Creatinine]] without significant decrease in [[GFR]]
+:*Increases [[serum creatinine]] without significant decrease in [[GFR]]
-:* Serum [[Creatinine]] rise is reversible on stopping [[Fenofibrate]]
+:*[[Serum creatinine]] rise is reversible on stopping [[fenofibrate]]
-* [[Gemfibrozil]]
+*[[Gemfibrozil]]
-:* Associated with [[Acute Renal Failure]] due to [[Rhabdomyolysis]]
+:*Associated with [[acute renal failure]] due to [[rhabdomyolysis]]
-* [[Statin]]s
+*[[Statin]]s
 ==Chemotherapy==
 *[[Carmustine]]
 *[[Carboplatin]]
-* [[Cisplatin]]
+*[[Cisplatin]]
-* [[Ifosfamide]]
+*[[Ifosfamide]]
-:* Causes [[Fanconi's Syndrome]]
+:* Causes [[fanconi's syndrome]]
+*[[Lomustine]]
+==Proton channel blockers==
+*[[Esomeprazole]]
+*[[Lansoprazole]]
+*[[Omeprazole]]
+*[[Pantoprazole]]
+*[[Rabeprazole]]
 ==Miscellaneous Drugs==
+* Chronic stimulant [[laxative]] use
-* Chronic stimulant [[Laxative]] use
+:* Resulting chronic volume depletion and [[hypokalemia]] causes [[nephropathy]]
-:* Resulting chronic volume depletion and [[Hypokalemia]] causes [[nephropathy]]
 * [[Radiocontrast agents]]
 * [[ACE Inhibitor]]s
 :* Expect an increase of [[serum creatinine]] in [[chronic kidney disease]]
 *[[Acetaminophen]]
+*[[Amitriptyline]]
 *[[Anticoagulants]]
+*[[Allopurinol]]
+*[[Aspirin]]
+:* Low dose [[aspirin]] reduces [[renal function]] in elderly
+:*:* Decreased [[creatinine clearance]] after 2 weeks of use
+:*:* Changes persisted for at least 3 weeks off [[aspirin]]
+*Aristocholic acid containing Chinese herbals
+*[[Bevacizumab]]
+*[[Carbon tetrachloride]]
+*[[Cimetidine]]
+*[[Ciprofloxacin]]
+*[[Clopidogrel]]
+*[[Dilantin]]
+*[[Diuretic]]s
+:*[[Thiazide]]s
+:*[[Furosemide]]
+:*[[Triamterene]]
+*[[Doxepin]]
+*[[Fluoxetine]]
+*[[H1 antagonist]]s
+:*[[Diphenhydramine]]
+:*[[Doxylamine]]
+*[[Infliximab]]
+*[[Interferon]]s
+*[[Mesalamine]] (Asacol, Pentasa)
+:*[[Mesalamine]] is an [[NSAID]] analog and has systemic absorption from the bowel
+*[[NSAID]]s: [[celecoxib]], [[ibuprofen]], [[naproxen]]
+:*[[Nephrotic syndrome]] type reaction
+*[[Penicillin]]s and [[cephalosporin]]s
+*[[Pamidronate]]
+*[[Propylthiouracil]]
+:*[[Hypersensitivity]] ([[fever]], [[rash]], [[arthralgia]])
+*[[Rifampin]]
+*[[Sulfonamide]]s
+:*[[Vasculitis]] reaction
+*[[Ticlopidine]]
+*[[Zoledronate]]
+==Drugs of abuse==
+*[[Cocaine]]
+*[[Heroin]]
+*[[Ketamine]]
+*[[Methadone]]
+*[[Methamphetamine]]
+==Nephrotoxic Drugs in Alphabetical Order==
+{{MultiCol}}
+* [[ACE Inhibitor]]s
+* [[Acetaminophen]]
+* [[Acyclovir]]
+* [[Adefovir]]
 * [[Allopurinol]]
+* [[Aminoglycosides]]
+* [[Amitriptyline]]
+* [[Amphotericin B]]
+* [[Angiotensin converting enzyme inhibitor]]s
+* [[Anticoagulants]]
+* [[Aristocholic acid containing Chinese herbals]]
+* [[Arsenic]] poisoning
 * [[Aspirin]]
-:* Low dose [[Aspirin]] reduces [[Renal function]] in elderly
+* [[Bevacizumab]]
-:*:* Decreased [[Creatinine Clearance]] after 2 weeks of use
+* [[Bismuth]]
-:*:* Changes persisted for at least 3 weeks off [[Aspirin]]
+* [[Carbon tetrachloride]]
-*[[Carbon tetrachloride]]
+* [[Carboplatin]]
+* [[Carmustine]]
+* [[Celecoxib]]
+* [[Cephalosporins]]
+* [[Chloroquine]]
+* [[Cidofovir]]
 * [[Cimetidine]]
 * [[Ciprofloxacin]]
+* [[Cisplatin]]
+* [[Clopidogrel]]
+* [[Cocaine]]
+* [[Cyclosporine]]
 * [[Dilantin]]
-* [[Diuretic]]s
+* [[Diphenhydramine]]
-:*[[Thiazide]]s
+* [[Diuretics]]
-:*[[Furosemide]]
+* [[Doxepin]]
+* [[Doxylamine]]
+* [[Erythromycin]]
+* [[Esomeprazole]]
+* [[Fenofibrate]] (Tricor)
+* [[Fluoxetine]]
+* [[Foscarnet]]
+* [[Furosemide]]
+* [[Gemfibrozil]]
+* [[Gentamycin]]
+* [[Gold]] therapy
+* [[H1 antagonist]]
+* [[Heroin]]
+* [[Hydroxychloroquine]]
+{{ColBreak}}
+* [[Ibuprofen]]
+* [[Ifosfamide]]
+* [[Indinavir]]
+* [[Infliximab]]
+* [[Interferon alpha]]
+* [[Interferon]]s
+* [[Isoniazide]]
+* [[Ketamine]]
+* [[Lansoprazole]]
+* [[Laxative]] use
+* [[Lead]] poisoning
+* [[Levofloxacin]]
+* [[Lithium]]
+* [[Lomustine]]
+* [[Mercury]] poisoning
 * [[Mesalamine]] (Asacol, Pentasa)
-:*:* [[Mesalamine]] is an [[NSAID]] analog and has systemic absorption from the bowel
+* [[Methadone]]
-* [[NSAID]]s: [[Celecoxib]]
+* [[Methamphetamine]]
-:* [[Nephrotic Syndrome]] type reaction
+* [[Methicillin]]
-* [[Penicillin]]s and [[Cephalosporin]]s
+* [[Methotrexate]]
-:* [[Hypersensitivity]] ([[fever]], [[rash]], [[arthralgia]])
+* [[Mitomycin]]
+* [[Naproxen]]
+* [[Nitrosourea compounds]]
+* [[NSAID]]s
+* [[Omeprazole]]
+* [[Pamidronate]]
+* [[Pantoprazole]]
+* [[Penicillin]]s
+* [[Pentamidine]]
+* [[Propylthiouracil]]
+* [[Proton pump inhibitors]]
+* [[Quinine]]
+* [[Rabeprazole]]
+* [[Radiocontrast agents]]
 * [[Rifampin]]
-* [[Sulfonamide]]s
+* [[Statins]]
-:* [[Vasculitis]] reaction
+* [[Sulfonamides]]
+* [[Tacrolimus]]
+* [[Tenofovir]]
+* [[Tetracycline]]
+* [[Thiazide]]s
+* [[Ticlopidine]]
+* [[Triamterene]]
+* [[Trimethadione]]
+* [[Vancomycin]]
+* [[Zoledronate]]
+{{EndMultiCol}}
-==Drugs of abuse==
+==References==
-* [[Cocaine]]
+{{reflist|2}}
 [[Category:Drugs]]

Nephrotoxic drugs: Difference between revisions

Latest revision as of 16:16, 10 August 2012

Overview

Common Nephrotoxic drugs

Antibiotics

Antibacterials

Antivirals

Antiparasitic drugs

Chemotherapy and Immunosuppressants

Heavy Metals and Poisons

AntiHyperlipidemics

Chemotherapy

Proton channel blockers

Miscellaneous Drugs

Drugs of abuse

Nephrotoxic Drugs in Alphabetical Order

References

Navigation menu