PTGIS: Difference between revisions
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'''Prostaglandin I2 (prostacyclin) synthase''' ('''PTGIS''') (also known as '''CYP8A1''') is a [[protein]] which in humans is encoded by the ''PTGIS'' [[gene]].<ref name="pmid8812456">{{cite journal | author = Yokoyama C, Yabuki T, Inoue H, Tone Y, Hara S, Hatae T, Nagata M, Takahashi EI, Tanabe T | title = Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity | journal = Genomics | volume = 36 | issue = 2 | pages = 296–304 | year = 1996 | month = September | pmid = 8812456 | doi = 10.1006/geno.1996.0465 | url = | issn = }}</ref> | '''Prostaglandin I2 (prostacyclin) synthase''' ('''PTGIS''') (also known as '''CYP8A1''') is a [[protein]] which in humans is encoded by the ''PTGIS'' [[gene]].<ref name="pmid8812456">{{cite journal | author = Yokoyama C, Yabuki T, Inoue H, Tone Y, Hara S, Hatae T, Nagata M, Takahashi EI, Tanabe T | title = Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity | journal = Genomics | volume = 36 | issue = 2 | pages = 296–304 | year = 1996 | month = September | pmid = 8812456 | doi = 10.1006/geno.1996.0465 | url = | issn = }}</ref> | ||
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Latest revision as of 14:42, 20 August 2012
| prostaglandin I2 (prostacyclin) synthase | |
|---|---|
| Identifiers | |
| Symbol | PTGIS |
| Alt. symbols | CYP8A1 |
| Entrez | 5740 |
| HUGO | 9603 |
| OMIM | 601699 |
| RefSeq | NM_000961 |
| UniProt | Q16647 |
| Other data | |
| EC number | 5.3.99.4 |
| Locus | Chr. 20 q13 |
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Evidence Based Medicine |
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Clinical Trials |
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Ongoing Trials on PTGIS at Clinical Trials.gov Clinical Trials on PTGIS at Google
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Guidelines / Policies / Govt |
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US National Guidelines Clearinghouse on PTGIS
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Commentary |
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Definitions |
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Patient Resources / Community |
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Directions to Hospitals Treating PTGIS Risk calculators and risk factors for PTGIS
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Healthcare Provider Resources |
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Continuing Medical Education (CME) |
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International |
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Experimental / Informatics |
Prostaglandin I2 (prostacyclin) synthase (PTGIS) (also known as CYP8A1) is a protein which in humans is encoded by the PTGIS gene.[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostaglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.[2]
See also
References
- ↑ Yokoyama C, Yabuki T, Inoue H, Tone Y, Hara S, Hatae T, Nagata M, Takahashi EI, Tanabe T (1996). "Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity". Genomics. 36 (2): 296–304. doi:10.1006/geno.1996.0465. PMID 8812456. Unknown parameter
|month=ignored (help) - ↑ "Entrez Gene: PTGIS".
This article incorporates text from the United States National Library of Medicine, which is in the public domain.