Pelger-Huet abnormality: Difference between revisions
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Latest revision as of 14:52, 20 August 2012
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| Pelger-Huet abnormality. (Image courtesy of Melih Aktan M.D.) |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pelger-Huet abnormality or Pelger-Huët anomaly (PHA) is a benign dominantly inherited defect of terminal neutrophil differentiation secondary to mutations in the lamin B receptor (LBR) gene.
Laboratory findings
Characteristics observed on blood smears include leukocytes with dumbbell-shaped bilobed nuclei; a reduced number of nuclear segments; and coarse clumping of the nuclear chromatin in neutrophils, lymphocytes, and monocytes.
Differential Diagnosis
Template:Skin and subcutaneous tissue symptoms and signs Template:Nervous and musculoskeletal system symptoms and signs Template:Urinary system symptoms and signs Template:Cognition, perception, emotional state and behaviour symptoms and signs Template:Speech and voice symptoms and signs Template:General symptoms and signs