Endocarditis pathology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editor-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Pathologic Findings in the Acute Phase

The valve and the surrounding anatomy should be carefully inspected for the following complications:

• Fistula
• Perforation
• Prosthetic dehiscence
• Aneurysm
• Vegetations
• Valve ulcers or erosions
• Rupture of chordaes
• Endocardial jet lesions
• Flail leaflets or cusps
• Abcess formation (annular and ring)

Pathologic Findings in the Chronic Phase

• Perforations
• Nodular calcifications
• Tissue defects of valves
• Fibrosis of valves

Gross Pathology of Endocarditis

Images shown in this section are courtesy of Professor Peter G. Anderson D.V.M. PhD, and published with permission.

© PEIR, University of Alabama at Birmingham, Department of Pathology

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  Thrombotic Nonbacterial Endocarditis: (Gross) An excellent example of thrombi on aortic valve.
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  Thrombotic Nonbacterial Endocarditis: (Gross) Mitral valve lesion appears that have been present for at least several days.

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  Bacterial Endocarditis: (Gross) Perforated aortic valve cusp is shown.
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  Thrombotic Nonbacterial Endocarditis: (Gross) Aortic valve with two small vegetations.

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  Thrombotic Nonbacterial Endocarditis: (Gross) Mitral valve thrombi in chorda.
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  (Gross) A very good example of focal necrotizing lesions in distal portion of digit associated with bacterial endocarditis

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  Bacterial Endocarditis: (Gross) A lesion on non-coronary cusp of aortic valve.
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  Bacterial Endocarditis: (Gross) An excellent view of mitral scarring due to rheumatic fever healing infectious lesion.

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  Bacterial Endocarditis: (Gross) Aortic valve prosthesis ring infection extending into left atrium.
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  Bacterial Endocarditis: (Gross) An excellent close-up view of mitral valve vegetations

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  Bacterial Endocarditis: (Gross) vegetations on mitral valve and left atrial endocardium due to actinomycosis
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  Bacterial Endocarditis: (Gross) An excellent image of vegetation on aortic valve

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  Bacterial Endocarditis: (Gross) An excellent image of vegetations on mitral valve evidence of rheumatic scarring
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  Thrombotic Nonbacterial Endocarditis: (Gross) Mitral valve, an excellent example

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  Thrombotic Nonbacterial Endocarditis: (Gross) Mitral valve: an excellent image, identical to acute rheumatic lesion
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  Verrucous Nonbacterial Endocarditis: (Gross) An excellent example of an infant heart

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  Purpura of cerebrum, cerebellum and brain stem in 36 years old female with Cushing syndrome and bacterial endocarditis caused by Staphylococcus aureus
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  Spleen infarct: (Gross) A typical small infarct with necrotic central portion (originated from infected marantic endocarditis on aortic and mitral valves)

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  Kidney infarct: (Gross) A natural color close-up and excellent image of yellow infarct marantic endocarditis on aortic and mitral valves
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  Thrombotic Nonbacterial Endocarditis Infected: (Gross) Natural color of pulmonary valve. An excellent example of patient with multiple myeloma

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  Thrombotic Non Bacterial Endocarditis: (Gross) Natural color of pulmonary valve.
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  Thrombotic Non Bacterial Endocarditis: (Gross) Natural color and good example of tricuspid valve lesions

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  Disseminated intravascular coagulation in endocarditis; tricuspid valve showing NBTE in DIC
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  Eye: Bacterial Endocarditis complicated as petechiae. Septic emboli to conjunctiva

Microscopic Pathology of Endocarditis

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