Myleofibrosis: Difference between revisions

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{{Myelofibrosis}}  
{{Myleofibrosis}}  
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'''Primary myelofibrosis''', also known as '''Myelofibrosis'''; '''Idiopathic myelofibrosis'''; '''Myeloid metaplasia'''; '''Agnogenic myeloid metaplasia''', is a disorder of the [[bone marrow]], in which the marrow is replaced by fibrous (scar) tissue ([[collagen]]).
==[[Myleofibrosis overview|Overview]]==


== Causes, incidence, and risk factors ==
==[[Myleofibrosis historical perspective|Historical Perspective]]==
In primary myelofibrosis, a progressive scarring ([[fibrosis]]) of the bone marrow occurs. As a result, blood forms in sites other than the bone marrow, such as the [[liver]] and [[spleen]]. This causes an enlargement of these organs. The cause and risk factors are unknown.  It commonly occurs in the spent phase of [[Polycythemia Rubra Vera]], possibly in response to the medication [[hydroxyurea]] poisoning the marrow.


The disorder usually develops slowly, in people over 50 years old. It leads to progressive bone marrow failure with severe [[anemia]]. Low platelet count leads to easy bleeding, and spleen enlargement continues.
==[[Myleofibrosis classification|Classification]]==


== Symptoms == 
==[[Myleofibrosis pathophysiology|Pathophysiology]]==
*Abdominal fullness related to an enlarged spleen
*Bone pain
*Bruising
*Easy bleeding
*Fatigue
*Increased susceptibility to infection
*Pallor
*Shortness of breath while doing physical work
*Uncontrollable [[diarrhea]]


== Treatment ==
==[[Myleofibrosis causes|Causes]]==
Myleofibrosis has no known cure.  [[Lenalidomide]] (brand name Revlimid) and [[Thalidomide]] are drugs that can be used in its treatment, though they can cause [[gout]] and leave the patient susceptible to diseases such as [[pneumonia]].  Frequent [[blood transfusions]] may also be required.


==[[Myleofibrosis differential diagnosis|Differentiating Myleofibrosis from other Diseases]]==


{{SIB}}
==[[Myleofibrosis epidemiology and demographics|Epidemiology and Demographics]]==


==[[Myleofibrosis risk factors|Risk Factors]]==
==[[Myleofibrosis screening|Screening]]==
==[[Myleofibrosis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
==Diagnosis==
[[Myleofibrosis history and symptoms| History and Symptoms]] | [[Myleofibrosis physical examination | Physical Examination]] |[[Myleofibrosis laboratory findings|Laboratory Findings]] | [[Myleofibrosis x ray|X Ray]] |  [[Myleofibrosis CT|CT]] | [[Myleofibrosis MRI|MRI]] | [[Myleofibrosis ultrasound|Ultrasound]] | [[Myleofibrosis other imaging findings|Other Imaging Findings]] | [[Myleofibrosis other diagnostic studies|Other Diagnostic Studies]]
==Treatment==
[[Myleofibrosis medical therapy|Medical Therapy]] | [[Myleofibrosis surgery|Surgery]] | [[Myleofibrosis primary prevention|Primary Prevention]] | [[Myleofibrosis secondary prevention|Secondary Prevention]] | [[Myleofibrosis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Myleofibrosis future or investigational therapies|Future or Investigational Therapies]]
==Case Studies==
[[Myleofibrosis case study one|Case#1]]
[[Category:Hematology]]
[[Category:Hematology]]


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{{WikiDoc Sources}}
{{WikiDoc Sources}}

Latest revision as of 15:39, 21 September 2012

Myleofibrosis Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Myleofibrosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

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Risk calculators and risk factors for Myleofibrosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Myleofibrosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination |Laboratory Findings | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case#1

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