Focal segmental glomerulosclerosis (patient information): Difference between revisions
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{{Focal segmental glomerulosclerosis (patient information)}} | {{Focal segmental glomerulosclerosis (patient information)}} | ||
'''For the WikiDoc page for this topic, click [[ Focal segmental glomerulosclerosis|here]]''' | |||
{{CMG}} {{AE}} {{RT}} | {{CMG}} {{AE}} {{RT}} | ||
==Overview== | ==Overview== | ||
Focal segmental glomerulosclerosis is scar tissue that forms in parts of the kidney called glomeruli. The glomeruli serve as filters, helping rid the body of unnecessary or harmful substances. Each kidney has thousands of glomeruli. One glomeruli is called a glomerulus. | [[Focal segmental glomerulosclerosis]] is scar tissue that forms in parts of the kidney called glomeruli. The glomeruli serve as filters, helping rid the body of unnecessary or harmful substances. Each kidney has thousands of glomeruli. One glomeruli is called a glomerulus. | ||
"Focal" means that some of the glomeruli become scarred, while others remain normal. "Segmental" means that only part of an individual glomerulus is damaged. | "Focal" means that some of the glomeruli become scarred, while others remain normal. "Segmental" means that only part of an individual glomerulus is damaged. | ||
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The cause of focal segmental glomerulosclerosis is usually unknown. | The cause of focal segmental glomerulosclerosis is usually unknown. | ||
The condition affects both children and adults. Men and boys are affected slightly more often than women and girls, and it also occurs more often in African Americans. Focal segmental glomerulosclerosis causes about 20 - 25% of all cases of [ | The condition affects both children and adults. Men and boys are affected slightly more often than women and girls, and it also occurs more often in African Americans. Focal segmental glomerulosclerosis causes about 20 - 25% of all cases of [[nephrotic syndrome]]. | ||
Known causes include: | Known causes include: | ||
* Heroin use | * [[Heroin]] use | ||
* [[HIV]] | * [[HIV]] | ||
* Inherited genetic problems | * Inherited genetic problems | ||
* Obesity | * [[Obesity]] | ||
* [[Reflux nephropathy]] (a condition in which urine flows backward from the bladder to the kidney) | * [[Reflux nephropathy]] (a condition in which urine flows backward from the bladder to the kidney) | ||
* [[Sickle cell disease]] | * [[Sickle cell disease]] | ||
==Diagnosis== | |||
The health care provider will perform a physical examination. This may detect tissue swelling and high blood pressure. Signs of kidney (renal) failure and excess fluid may develop as the condition gets worse. | |||
Tests may include: | |||
* [[Kidney biopsy]] | |||
* [[Kidney function tests]] (blood and urine) | |||
* [[Urinalysis]] | |||
* Urine microscopy | |||
* [[Urine protein]] | |||
==When to seek urgent medical care?== | |||
You should call your doctor if you develop symptoms of this condition, especially if there is fever, pain with urination, or decreased urine output. | |||
==Treatment options== | |||
Some patients will receive high doses of corticosteroids or a drug called cyclosporine to suppress their immune system. | |||
The goal of treatment is to control the symptoms of nephrotic syndrome and prevent chronic kidney failure. | |||
In general, treatments may include: | |||
* [[Antibiotics]] to control infections | |||
* [[Anti-inflammatory medicines]] to reduce the immune response | |||
* [[Dialysis]] | |||
* Fluid restriction | |||
* [[Kidney transplant]] | |||
* Low-fat diet | |||
* Low- or moderate-protein diet (1 gram of protein per kilogram of body weight per day) | |||
* Medicines to treat high blood pressure, [[high blood cholesterol]], and high triglyceride levels | |||
* Salt-reduced diet | |||
* [[Vitamin D]] supplement | |||
==Where to find medical care for Focal segmental glomerulosclerosis?== | |||
http://maps.google.com/maps?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|map+top+hospital+Focal segmental glomerulosclerosis}}}}&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&ie=UTF-8&sa=N&hl=en&tab=wl | |||
==Prevention== | |||
No prevention is known. | |||
==What to expect (Outlook/Prognosis)?== | |||
More than half of those with focal or segmental glomerulosclerosis develop [[chronic kidney failure]] within 10 years. | |||
==Possible complications== | |||
* [[Chronic kidney failure]] | |||
* [[End-stage kidney disease]] | |||
* [[Infection]] | |||
* [[Malnutrition]] | |||
* [[Nephrotic syndrome]] | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Nephrology]] | |||
[[Category:Patient information]] | |||
Latest revision as of 02:40, 29 September 2012
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Focal segmental glomerulosclerosis |
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Where to find medical care for Focal segmental glomerulosclerosis? |
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Focal segmental glomerulosclerosis On the Web |
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Directions to Hospitals Treating Focal segmental glomerulosclerosis |
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Risk calculators and risk factors for Focal segmental glomerulosclerosis |
For the WikiDoc page for this topic, click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Overview
Focal segmental glomerulosclerosis is scar tissue that forms in parts of the kidney called glomeruli. The glomeruli serve as filters, helping rid the body of unnecessary or harmful substances. Each kidney has thousands of glomeruli. One glomeruli is called a glomerulus.
"Focal" means that some of the glomeruli become scarred, while others remain normal. "Segmental" means that only part of an individual glomerulus is damaged.
What are the symptoms of Focal segmental glomerulosclerosis?
- Foamy urine (from excess protein in the urine)
- Poor appetite
- Swelling, called generalized edema, from fluids held in the body
- Weight gain
What causes Focal segmental glomerulosclerosis?
The cause of focal segmental glomerulosclerosis is usually unknown.
The condition affects both children and adults. Men and boys are affected slightly more often than women and girls, and it also occurs more often in African Americans. Focal segmental glomerulosclerosis causes about 20 - 25% of all cases of nephrotic syndrome.
Known causes include:
- Heroin use
- HIV
- Inherited genetic problems
- Obesity
- Reflux nephropathy (a condition in which urine flows backward from the bladder to the kidney)
- Sickle cell disease
Diagnosis
The health care provider will perform a physical examination. This may detect tissue swelling and high blood pressure. Signs of kidney (renal) failure and excess fluid may develop as the condition gets worse.
Tests may include:
- Kidney biopsy
- Kidney function tests (blood and urine)
- Urinalysis
- Urine microscopy
- Urine protein
When to seek urgent medical care?
You should call your doctor if you develop symptoms of this condition, especially if there is fever, pain with urination, or decreased urine output.
Treatment options
Some patients will receive high doses of corticosteroids or a drug called cyclosporine to suppress their immune system.
The goal of treatment is to control the symptoms of nephrotic syndrome and prevent chronic kidney failure.
In general, treatments may include:
- Antibiotics to control infections
- Anti-inflammatory medicines to reduce the immune response
- Dialysis
- Fluid restriction
- Kidney transplant
- Low-fat diet
- Low- or moderate-protein diet (1 gram of protein per kilogram of body weight per day)
- Medicines to treat high blood pressure, high blood cholesterol, and high triglyceride levels
- Salt-reduced diet
- Vitamin D supplement
Where to find medical care for Focal segmental glomerulosclerosis?
Prevention
No prevention is known.
What to expect (Outlook/Prognosis)?
More than half of those with focal or segmental glomerulosclerosis develop chronic kidney failure within 10 years.