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| {{Infobox_Disease | | | {{Infobox_Disease | |
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| MeshID = D016171 | | | MeshID = D016171 | |
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| {{SI}} | | {{Torsades de pointes}} |
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| {{CMG}}; '''Associate Editor(s)-In-Chief:''' {{CZ}} | | {{CMG}}; '''Associate Editor(s)-In-Chief:''' {{CZ}} |
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| ==Overview== | | ==[[Torsades de pointes overview|Overview]]== |
| '''Torsade de pointes''' in French means "Twisting of the Points". It is characterized by a polymorphic [[ventricular tachycardia]] and can occur in the congenital long QT syndromes, electrolyte abnormalities ([[hypomagnesemia]], [[hypokalemia]]), usage of certain drugs like [[antiarrhythmic]] ([[quinidine]]), nonsedating [[antihistamines]] ([[terfenadine]]); antibiotics ([[erythromycin]]) and neuroleptics ([[thioridazine]]).
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| Torsade de pointes is characterized by constantly changing rhythm amplitude. The changing rhythm amplitudes comes from the ventricular depolarizing waves constantly shifting its axis. The underlying mechanism is thought to be triggered activity arising as a consequence of early after-depolarizations. Torsade de pointes is typically initiated by a short-long-short interval. A ventricle extrasystole (first beat: short) is followed by a compensatory pause. The following beat (second beat: long) has a longer [[QT interval]]. If the next beat follows shortly thereafter, there is a good chance that this third beat falls within the [[QT interval]], resulting in the R on T phenomenon and subsequent [[Torsade de pointes]]. During [[Torsade de pointes]] the ventricles depolarize in a circular fashion resulting in QRS complexes with a continuously turning heart axis around the baseline (hence the name ''Torsade de Pointes'').
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| An understanding of the patho-physiology has led to development of treatment modalities like [[pacing]], [[isoproterenol]] and drugs like [[magnesium]] and [[beta blockers]]. Although Torsades de Pointes (TdP) is a rare ventricular arrhythmia, it can degenerate into ventricular fibrillation, leading to death without rapid medical intervention. TdP is associated with long QT syndrome, a condition whereby prolonged QT intervals are visible on the ECG.
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| Also, a more rare form of short coupled [[Torsade de pointes]] has been observed.<ref name="Leenhardt"> Leenhardt A, Glaser E, Burguera M, Nuernberg M, Maison-Blanche P, and Coumel P. Short-coupled variant of torsade de pointes. A new electrocardiographic entity in the spectrum of idiopathic ventricular tachyarrhythmias. Circulation 1994 Jan; 89(1) 206-15. PMID 8281648 </ref>
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| ==Historical Perspective== | | ==[[Torsades de pointes historical perspective|Historical Perspective]]== |
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| * It was first described by [[Dessertenne]] in 1966<ref>{{cite journal |author=Dessertenne F |title=[Ventricular tachycardia with 2 variable opposing foci] |language=French |journal=Archives des maladies du coeur et des vaisseaux |volume=59 |issue=2 |pages=263-72 |year=1966 |pmid=4956181 |doi=}}</ref> and refers to a specific variety of [[ventricular tachycardia]] that exhibits distinct characteristics on the [[electrocardiogram]] (ECG).
| | ==[[Torsades de pointes pathophysiology|Pathophysiology]]== |
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| * The French term is largely due to the fact that the phenomenon was originally described in a French [[medical journal]] by [[Dessertenne]] in 1966, when he observed this rhythm disorder in an 80-year-old female patient with complete intermittent [[atrioventricular]] block.
| | ==[[Torsades de pointes causes|Causes]]== |
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| * There has been much debate in the ''Circulation'' journal among French and American scientist whether one should write '''Torsades de Pointes''' or '''Torsade de Pointes'''.
| | ==[[Torsades de pointes differential diagnosis|Differentiating Torsades de pointes from other Diseases]]== |
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| * As for now ''Torsade'' is prefered (unless one sees rotations around more than one axis in one episode), but both forms are used in similar frequency.<ref>Moise NS. As Americans, we should get this right. Circulation 1999 Sep 28; 100(13) 1462. PMID 10500317 </ref>
| | ==[[Torsades de pointes risk factors|Risk Factors]]== |
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| ==History and symptoms== | | ==[[Torsades de pointes natural history, complications and prognosis|Natural History, Complications and Prognosis]]== |
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| '''Torsades''' is a rapid, polymorphic ventricular tachycardia with a characteristic twist of the QRS complex around the isoelectric baseline. It is also associated with a fall in arterial blood pressure, which gives rise to the syncopal symptoms experienced by patients. Although torsade de pointes is a rare ventricular arrhythmia, it can degenerate into ventricular fibrillation, which will lead to sudden death in the absence of medical intervention.
| | ==Diagnosis== |
| ===History=== | |
| It is important to gather the following information from the patient:
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| * History of congenital [[long QT syndrome]]
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| * Family history of [[sudden cardiac death]]
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| * Family history of [[sudden infant death syndrome]]
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| * Family history of congenital deafness ([[Jervell and Lange-Nielsen syndrome]] presenting with congenital sensorineural deafness and cardiac abnormalities)
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| * Family history of congenital long QT syndrome with normal hearing i.e. [[Romano-Ward syndrome]]
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| * Medication history to rule out acquired causes of [[Torsade de pointes]]
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| ===Symptoms===
| | [[Torsades de pointes history and symptoms|History and Symptoms]] | [[Torsades de pointes physical examination|Physical Examination]] | [[Torsades de pointes laboratory findings|Laboratory Findings]] | [[Torsades de pointes electrocardiogram|Electrocardiogram]] | [[Torsades de pointes ekg examples|EKG Examples]] | [[Torsades de pointes echocardiography|Echocardiography]] | [[Torsades de pointes other diagnostic studies|Other Diagnostic Studies]] |
| * [[Nausea]], [[vomiting]]
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| * [[Shortness of breath]]
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| * [[Chest pain]]
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| * Recurrent [[palpitations]]
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| * [[Dizziness]]
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| * [[Syncope]]
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| * [[Sudden cardiac death]]
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| ==Physical examination==
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| Physical examination findings depends on the rate and duration of the episode and the effect on cerebral perfusion during the episode. The physical finding may include:
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| * [[Pallor]] and [[diaphoresis]]
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| * [[Bradycardia]] followed by [[tachycardia]]
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| * [[Loss of consciousness]]
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| ==Causes==
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| Long QT syndrome can either be inherited as congenital mutations of ion channels carrying the cardiac impulse/action potential or acquired as a result of drugs that block these cardiac ion currents.
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| Common causes for torsades de pointes include [[hypomagnesemia]] and [[hypokalemia]]. It is commonly seen in malnourished individuals and chronic [[alcoholism|alcoholics]]. Drug interactions such as erythromycin or Avelox, taken concomitantly with inhibitors like nitroimidazole, [[Diarrhea]], dietary supplements, and various medications like [[methadone]], [[Lithium]], [[tricyclic antidepressants]] or [[phenothiazines]] may also contribute.
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| Factors that are associated with an increased tendency toward torsades de pointes include:
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| * [[Familial long QT syndrome]]
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| * [[antiarrhythmic drug|Class IA antiarrhythmics]]
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| * [[Hypomagnesemia]]
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| * [[Hypokalemia]]
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| * [[Hypoxia (medical)|Hypoxia]]
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| * [[Acidosis]]
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| * [[Heart failure]]
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| * [[Left ventricular hypertrophy]]
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| * [[bradycardia|Slow heart rate]]
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| * [[Female|Female gender]]
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| * Baseline electrocardiographic abnormalities
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| * Renal or liver failure
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| ===The List of Drugs that Causing Torsades de pointes===
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| Drugs that are generally accepted to have a risk of causing torsades de pointes
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| * [[Amiodarone ]]
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| * [[Arsenic trioxide ]]
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| * [[Astemizole ]]
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| * [[Bepridil ]]
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| * [[Chloroquine ]]
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| * [[Chlorpromazine ]]
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| * [[Cisapride ]]
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| * [[Clarithromycin ]]
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| * [[Disopyramide ]]
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| * [[Dofetilide ]]
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| * [[Domperidone ]]
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| * [[Droperidol ]]
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| * [[Erythromycin ]]
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| * [[Halofantrine ]]
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| * [[Haloperidol ]]
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| * [[Ibutilide ]]
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| * [[Levomethadyl ]]
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| * [[Mesoridazine]]
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| * [[Methadone ]]
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| * [[Pentamidine]]
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| * [[Pimozide ]]
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| * [[Probucol ]]
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| * [[Procainamide]]
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| * [[Quinidine ]]
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| * [[Sotalol ]]
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| * [[Sparfloxacin ]]
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| * [[Terfenadine ]]
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| * [[Thioridazine]]
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| ===Drugs that Possibly Cause Torsades de pointes ===
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| Drugs that in some reports have been associated with torsades de pointes and/or QT prolongation but at this time lack substantial evidence for causing torsades de pointes.
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| * [[Alfuzosin ]]
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| * [[Amantadine ]]
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| * [[Atazanavir ]]
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| * [[Azithromycin ]]
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| * [[Chloral hydrate ]]
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| * [[Clozapine ]]
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| * [[Dolasetron ]]
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| * [[Felbamate ]]
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| * [[Flecainide ]]
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| * [[Foscarnet ]]
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| * [[Fosphenytoin ]]
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| * [[Gatifloxacin ]]
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| * [[Gemifloxacin ]]
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| * [[Granisetron ]]
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| * [[Indapamide ]]
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| * [[Isradipine ]]
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| * [[Levofloxacin ]]
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| * [[Lithium ]]
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| * [[Moexipril]] / [[HCTZ ]]
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| * [[Moxifloxacin ]]
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| * [[Nicardipine ]]
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| * [[Octreotide ]]
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| * [[Ofloxacin ]]
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| * [[Ondansetron]]
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| * [[Oxytocin ]]
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| * [[Paliperidone ]]
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| * [[Perflutren]]
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| * [[Quetiapine ]]
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| * [[Ranolazine ]]
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| * [[Risperidone ]]
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| * [[Roxithromycin]]
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| * [[Sunitinib ]]
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| * [[Tacrolimus ]]
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| * [[Tamoxifen ]]
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| * [[Telithromycin]]
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| * [[Tizanidine ]]
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| * [[Vardenafil ]]
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| * [[Venlafaxine ]]
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| * [[Voriconazole ]]
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| * [[Ziprasidone]]
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| ===The List of Drugs that Causing Torsades de pointes in Certain Conditions===
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| Drugs that, in some reports, have been weakly associated with torsades de pointes and/or QT prolongation but that are unlikely to be a risk for torsades de pointes when used in usual recommended dosages and in patients without other risk factors (e.g., concomitant QT prolonging drugs, bradycardia, electrolyte disturbances, congenital long QT syndrome, concomitant drugs that inhibit metabolism)
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| * [[Amitriptyline ]]
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| * [[Amoxapine ]]
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| * [[Ciprofloxacin]]
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| * [[Citalopram ]]
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| * [[Clomipramine ]]
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| * [[Desipramine ]]
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| * [[Doxepin ]]
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| * [[Fluconazole ]]
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| * [[Fluoxetine ]]
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| * [[Galantamine ]]
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| * [[Imipramine ]]
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| * [[Itraconazole ]]
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| * [[Ketoconazole ]]
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| * [[Mexiletine ]]
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| * [[Nortriptyline]]
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| * [[Paroxetine ]]
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| * [[Protriptyline]]
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| * [[Sertraline ]]
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| * [[Solifenacin ]]
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| * [[Trimethoprim-Sulfamethoxazole]]
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| * [[Trimipramine]]
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| ==Differential diagnosis==
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| * [[Ventricular Tachycardia]] (polymorphic, monomorphic)
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| * [[Supraventricular tachycardia]]
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| * [[Ventricular Fibrillation]]
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| * [[Sudden Cardiac Death]]
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| * [[Syncope]]
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| * [[Renal Failure]]
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| * Dialysis complication
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| * Drug toxicity like [[antiarrhythmic]], [[Antihistaminics]]
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| ==Electrocardiography==
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| [[EKG]] is the main diagnostic tool in patients with [[Torsade de pointes]]. EKG findings that can be seen are:
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| * Progressive change in polarity of QRS about the isoelectric line occurs
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| * Prolonged QT interval ('''QT ≥ 0.60 s or QTc ≥ 0.45 s''')
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| * Pathological U
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| * Rotation of the heart's electrical axis by at least 180º
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| * Preceded by short long and short RR-intervals
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| * Triggered by an early [[premature ventricular contraction]](R-on-T PVC)
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| * Paroxysms of 5-20 beats at a rate ≥ 200 bpm
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| * Patients may revert spontaneously to a nonpolymorphic ventricular tachycardia or ventricular fibrillation
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| ==Video: Torsade de pointes==
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| {{#ev:youtube|1ccTO6fNobU}}
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| {{#ev:youtube|JDumoHHZocA}}
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| '''Torsade de pointes is characterized by constantly changing rhythm amplitude. 'Torsade de pointes' in French means "Twisting of the Points". The changing rhythm amplitudes comes from the ventricular depolarizing waves constantly shifting its axis. It is usually caused by hypomagnesemia, hypokalemia, and malnourished alcoholics. Although Torsades de Pointes (TdP) is a rare ventricular arrhythmia, it can degenerate into ventricular fibrillation, leading to death without rapid medical intervention. TdP is associated with long QT syndrome, a condition whereby prolonged QT intervals are visible on the ECG.'''
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| ==Other lab studies==
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| * Electrolytes levels to rule out [[hypokalemia]], [[hypomagnesemia]], and [[hypocalcemia]].
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| * [[Cardiac enzymes]]
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| * [[Echocardiography]] to rule out structural heart disease
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| ==Treatment== | | ==Treatment== |
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| ===Acute Treatment ===
| | [[Torsades de pointes medical therapy|Medical Therapy]] | [[Torsades de pointes primary prevention|Primary Prevention]] | [[Torsades de pointes secondary prevention|Secondary Prevention]] | [[Torsades de pointes cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Torsades de pointes future or investigational therapies|Future or Investigational Therapies]] |
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| If the episode of does not terminate on its own and degenerates into ventricular fibrillation, [[cardioversion]] is required.
| | ==Case Studies== |
| | [[Torsades de pointes case study one|Case #1]] |
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| [[Image:Torsades_converted_by_AICD_ECG_strip_Lead_II.JPG|thumb|center|800px|Lead II [[electrocardiogram]] showing [[Torsades]] being shocked by an [[Implantable cardioverter-defibrillator]] back to the patients baseline [[cardiac rhythm]].]]
| | ==Related Chapters== |
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| Once the patient is back in normal sinus rhythm, a vigorous search for and correction of conditions that predispose to torsades de pointes which include [[hypokalemia]], [[hypomagnesemia]], and [[bradycardia]] should be made. [[Magnesium sulfate]] (1-2 g IV over 30-60 seconds) reduces the influx of calcium thereby lowering the amplitude of early after depolarizations and should also be infused even if the magnesium is normal. <ref name="pmid15466950">{{cite journal |author=Hoshino K, Ogawa K, Hishitani T, Isobe T, Eto Y |title=Optimal administration dosage of magnesium sulfate for torsades de pointes in children with long QT syndrome |journal=J Am Coll Nutr |volume=23 |issue=5 |pages=497S–500S |year=2004 |month=October |pmid=15466950 |doi= |url=http://www.jacn.org/cgi/pmidlookup?view=long&pmid=15466950}}</ref><ref name="pmid16635167">{{cite journal |author=Hoshino K, Ogawa K, Hishitani T, Isobe T, Etoh Y |title=Successful uses of magnesium sulfate for torsades de pointes in children with long QT syndrome |journal=Pediatr Int |volume=48 |issue=2 |pages=112–7 |year=2006 |month=April |pmid=16635167 |doi=10.1111/j.1442-200X.2006.02177.x |url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1328-8067&date=2006&volume=48&issue=2&spage=112}}</ref>
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| Administration of [[lidocaine]] is generally not effective, but mexiletene may be helpful in suppressing the recurrence of torsade de pointes.
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| ==Additional Information==
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| *[[Torsade de Pointes and Polymorphic VT]] | | *[[Torsade de Pointes and Polymorphic VT]] |
| | | *[[Long QT syndrome]] |
| ==External Links==
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| [http://www.torsades.org/medical-pros/drug-lists/drug-lists.htm Torsade de Pointes related drug list]
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| ==Examples==
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| '''EKG's shown below are courtesy of [[C. Michael Gibson]] MS MD, and copylefted'''
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| <gallery perRow="3">
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| image:TdP.1.1.jpg|12 lead EKG at admission
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| image:TdP.1.2.1.jpg
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| image:TdP.1.2.2.jpg
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| image:TdP.1.3.1.jpg
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| image:TdP.1.3.2.jpg
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| image:TdP.1.4.1.jpg
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| image:TdP.1.4.2.jpg
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| image:TdP.1.5.1.jpg
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| image:TdP.1.5.2.jpg
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| image:TdP.1.6.1.jpg
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| image:TdP.1.6.2.jpg
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| image:TdP.1.7.jpg
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| </gallery>
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| '''Examples from different resources'''
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| <div align="left">
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| <gallery heights="175" widths="175">
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| image:shortcoupled_tdp1.jpg|Arrhythmias in a patient with short coupled torsade de pointes<ref name="Leenhardt"> Leenhardt A, Glaser E, Burguera M, Nuernberg M, Maison-Blanche P, and Coumel P. Short-coupled variant of torsade de pointes. A new electrocardiographic entity in the spectrum of idiopathic ventricular tachyarrhythmias. Circulation 1994 Jan; 89(1) 206-15. PMID 8281648 </ref>
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| image:shortcoupled_tdp2.jpg|Arrhythmias in a patient with short coupled torsades de pointes degenerating in [[ventricular fibrillation]]<ref name="Leenhardt"> Leenhardt A, Glaser E, Burguera M, Nuernberg M, Maison-Blanche P, and Coumel P. Short-coupled variant of torsade de pointes. A new electrocardiographic entity in the spectrum of idiopathic ventricular tachyarrhythmias. Circulation 1994 Jan; 89(1) 206-15. PMID 8281648 </ref>
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| image:shortcoupled_tdp3.jpg|Arrhythmias in a patient with short coupled torsade de pointes: frequent short coupled extrasystoles<ref name="Leenhardt"> Leenhardt A, Glaser E, Burguera M, Nuernberg M, Maison-Blanche P, and Coumel P. Short-coupled variant of torsade de pointes. A new electrocardiographic entity in the spectrum of idiopathic ventricular tachyarrhythmias. Circulation 1994 Jan; 89(1) 206-15. PMID 8281648 </ref>
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| image:shortcoupled_tdp4.jpg|Arrhythmias in a patient with short coupled torsade de pointes: frequent short coupled extrasystoles <ref name="Leenhardt"> Leenhardt A, Glaser E, Burguera M, Nuernberg M, Maison-Blanche P, and Coumel P. Short-coupled variant of torsade de pointes. A new electrocardiographic entity in the spectrum of idiopathic ventricular tachyarrhythmias. Circulation 1994 Jan; 89(1) 206-15. PMID 8281648 </ref>
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| image:12leadTorsade.jpg|A 12 lead ECG recording example of TdP<ref>Khan IA. Twelve-lead electrocardiogram of torsade de pointes Tex Heart Inst J. 2001; 28 (1): 69. PMID 11330748 </ref>
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| </gallery>
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| </div>
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| [[Image:Tosadesdepointes.jpg|center|thumb|300px|Characteristic tracing showing the "twisting" (blue line) of Torsade de pointes]]
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| ==References==
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| {{Reflist|2}}
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| [[de:Torsade de pointes]]
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| [[pl:Torsade de pointes]] | | [[pl:Torsade de pointes]] |
| [[tr:Torsade de pointes]] | | [[tr:Torsade de pointes]] |
