Leukoencephalopathy with vanishing white matter: Difference between revisions
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{{SK}} CACH; childhood ataxia with central nervous system hypomyelinization; vanishing white matter leukodystrophy; cree leukoencephalopathy; CLE; vanishing white matter leukodystrophy with ovarian failure, included; ovarioleukodystrophy, included | |||
==Overview== | ==Overview== | ||
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--><ref name="pmid17470759">{{cite journal |author=Denier C, Orgibet A, Roffi F, Jouvent E, Buhl C, Niel F, Boespflug-Tanguy O, Said G, Ducreux D |title=Adult-onset vanishing white matter leukoencephalopathy presenting as psychosis |journal=Neurology |volume=68 |issue=18 |pages=1538-9 |year=2007 |pmid=17470759 |doi=10.1212/01.wnl.0000260701.76868.44}}</ref> | --><ref name="pmid17470759">{{cite journal |author=Denier C, Orgibet A, Roffi F, Jouvent E, Buhl C, Niel F, Boespflug-Tanguy O, Said G, Ducreux D |title=Adult-onset vanishing white matter leukoencephalopathy presenting as psychosis |journal=Neurology |volume=68 |issue=18 |pages=1538-9 |year=2007 |pmid=17470759 |doi=10.1212/01.wnl.0000260701.76868.44}}</ref> | ||
==Related Chapters== | ==Related Chapters== | ||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
Latest revision as of 16:20, 5 December 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: CACH; childhood ataxia with central nervous system hypomyelinization; vanishing white matter leukodystrophy; cree leukoencephalopathy; CLE; vanishing white matter leukodystrophy with ovarian failure, included; ovarioleukodystrophy, included
Overview
Leukoencephalopathy with vanishing white matter (VWM disease) is an autosomal recessive neurological disease. The cause of the disease are mutations in any of the 5 genes encoding subunits of the translation initiation factor EIF2B: EIF2B1, EIF2B2, EIF2B3, EIF2B4, or EIF2B5.
Adult-onset VWM disease can present with psychosis and may be hard to differentiate from schizophrenia.[1]
Related Chapters
- CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy)
- Progressive multifocal leukoencephalopathy
- Metachromatic leukodystrophy
References
- ↑ Denier C, Orgibet A, Roffi F, Jouvent E, Buhl C, Niel F, Boespflug-Tanguy O, Said G, Ducreux D (2007). "Adult-onset vanishing white matter leukoencephalopathy presenting as psychosis". Neurology. 68 (18): 1538–9. doi:10.1212/01.wnl.0000260701.76868.44. PMID 17470759.