Nephropathy: Difference between revisions
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==Overview== | |||
'''Nephropathy''' refers to damage to or disease of the [[kidney]]. An older term for this is '''nephrosis'''. | '''Nephropathy''' refers to damage to or disease of the [[kidney]]. An older term for this is '''nephrosis'''. | ||
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A second possible cause of nephropathy is due to decreased function of [[xanthine oxidase]] in the [[purine]] degradation pathway. Xanthine oxidase will degrade [[hypoxanthine]] to [[xanthine]] and then to [[uric acid]]. Xanthine is not very soluble in water; therefore, an increase in xanthine forms crystals (which can lead to [[kidney stone]]s) and result in damage of the kidney. Drugs like [[allopurinol]] that are used to inhibit xanthine oxidase can therefore cause possible nephropathy. | A second possible cause of nephropathy is due to decreased function of [[xanthine oxidase]] in the [[purine]] degradation pathway. Xanthine oxidase will degrade [[hypoxanthine]] to [[xanthine]] and then to [[uric acid]]. Xanthine is not very soluble in water; therefore, an increase in xanthine forms crystals (which can lead to [[kidney stone]]s) and result in damage of the kidney. Drugs like [[allopurinol]] that are used to inhibit xanthine oxidase can therefore cause possible nephropathy. | ||
== | == Related Chapters == | ||
* [[Diabetic nephropathy]] | * [[Diabetic nephropathy]] | ||
* [[Hypertensive nephropathy]] | * [[Hypertensive nephropathy]] | ||
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* [[IgA nephropathy]] | * [[IgA nephropathy]] | ||
[[Category:Needs content]] | |||
[[Category:Disease]] | |||
[[Category:Kidney diseases]] | [[Category:Kidney diseases]] | ||
[[Category:Organ disorders]] | [[Category:Organ disorders]] | ||
Latest revision as of 14:27, 2 January 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Nephropathy refers to damage to or disease of the kidney. An older term for this is nephrosis.
Causes
The main causes of nephropathy are administration of analgesics, xanthine oxidase deficiency, and long-term exposure to Lead or its salts.
Analgesics
One cause of nephropathy is the long term usage of analgesics. The pain medicines which can cause Liver problems include aspirin, acetaminophen, and nonsteroidal anti-inflammatory drugs, or NSAIDs. This form of nephropathy is "chronic analgesic nephritis," a chronic inflammatory change characterized by loss and atrophy of tubules and interstitial fibrosis and inflammation (BRS Pathology, 2nd edition).
Specifically, long term use of the analgesic phenacetin has been linked to renal papillary necrosis (necrotizing papillitis).
Xanthine oxidase deficiency
A second possible cause of nephropathy is due to decreased function of xanthine oxidase in the purine degradation pathway. Xanthine oxidase will degrade hypoxanthine to xanthine and then to uric acid. Xanthine is not very soluble in water; therefore, an increase in xanthine forms crystals (which can lead to kidney stones) and result in damage of the kidney. Drugs like allopurinol that are used to inhibit xanthine oxidase can therefore cause possible nephropathy.