Drug allergy natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
In general, any allergic reaction will worsen with continued exposure to the offending agent. [[Anaphylaxis]] will most certainly progress to death if untreated, and the same is true for the severe allergic reactions such as [[Stevens-Johnson syndrome]] and [[toxic epidermal necrolysis]]. | |||
==Natural History== | ==Natural History== | ||
*[[Stevens-Johnson syndrome]] starts with a generalized macropapular rash, that will then progress to bullae, mucous membrane [[ulcerations]], [[conjunctivitis]], [[fever]], [[sore throat]], and [[fatigue]]. | *[[Stevens-Johnson syndrome]] starts with a generalized macropapular rash, that will then progress to bullae, mucous membrane [[ulcerations]], [[conjunctivitis]], [[fever]], [[sore throat]], and [[fatigue]]. | ||
*[[Toxic epidermal necrolysis]] will progress similarly to [[Stevens-Johnson syndrome]], but will also cause large layers of the [[epidermis]] to detatch from the layers below, leading to extreme amounts of sloughing of the skin surface, and an appearance of the skin that looks like burns or scalding. | *[[Toxic epidermal necrolysis]] will progress similarly to [[Stevens-Johnson syndrome]], but will also cause large layers of the [[epidermis]] to detatch from the layers below, leading to extreme amounts of sloughing of the skin surface, and an appearance of the skin that looks like burns or scalding. | ||
==References== | |||
{{reflist|2}} | |||
[[Category:Allergology]] | |||
[[Category:Immunology]] | |||
[[Category:Emergency medicine]] | |||
[[Category:Needs content]] | |||
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Latest revision as of 21:41, 13 February 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2] Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.
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Overview
In general, any allergic reaction will worsen with continued exposure to the offending agent. Anaphylaxis will most certainly progress to death if untreated, and the same is true for the severe allergic reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis.
Natural History
- Stevens-Johnson syndrome starts with a generalized macropapular rash, that will then progress to bullae, mucous membrane ulcerations, conjunctivitis, fever, sore throat, and fatigue.
- Toxic epidermal necrolysis will progress similarly to Stevens-Johnson syndrome, but will also cause large layers of the epidermis to detatch from the layers below, leading to extreme amounts of sloughing of the skin surface, and an appearance of the skin that looks like burns or scalding.