Pancreas divisum pathophysiology: Difference between revisions
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*Variant of the pancreatic ductal system and occurs in 4%–10% of the population. | *Variant of the pancreatic ductal system and occurs in 4%–10% of the population. | ||
*Dorsal and ventral anlagen of the pancreas fail to fuse. | *Dorsal and ventral anlagen of the pancreas fail to fuse. | ||
**The dorsal duct drains most of the glandular parenchyma through the minor papilla | **The dorsal duct drains most of the glandular parenchyma through the minor papilla. | ||
**The smaller ventral duct drains a portion of the pancreatic head, including the uncinate process, through the major papilla. | **The smaller ventral duct drains a portion of the pancreatic head, including the uncinate process, through the major papilla. | ||
*Clinical relevance of pancreas divisum remains controversial. | *Clinical relevance of pancreas divisum remains controversial. | ||
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**In some patients, this anomaly is associated with recurrent episodes of [[pancreatitis]]. | **In some patients, this anomaly is associated with recurrent episodes of [[pancreatitis]]. | ||
**Postulated that in pancreas divisum, the duct of Santorini and the minor ampulla are too small to adequately drain the secretions produced by the pancreatic body and tail. | **Postulated that in pancreas divisum, the duct of Santorini and the minor ampulla are too small to adequately drain the secretions produced by the pancreatic body and tail. | ||
===Associated Conditions=== | |||
An association with [[adenoma]] of the minor papilla has been reported.<ref name="pmid18019730">{{cite journal |author=Nakamura Y, Tajiri T, Uchida E, ''et al'' |title=Adenoma of the minor papilla associated with pancreas divisum |journal=Hepatogastroenterology |volume=54 |issue=78 |pages=1841–3 |year=2007 |pmid=18019730 |doi=}}</ref> | |||
==References== | ==References== | ||
Latest revision as of 12:33, 11 April 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
- Variant of the pancreatic ductal system and occurs in 4%–10% of the population.
- Dorsal and ventral anlagen of the pancreas fail to fuse.
- The dorsal duct drains most of the glandular parenchyma through the minor papilla.
- The smaller ventral duct drains a portion of the pancreatic head, including the uncinate process, through the major papilla.
- Clinical relevance of pancreas divisum remains controversial.
- Most patients with pancreas divisum are asymptomatic.
- In some patients, this anomaly is associated with recurrent episodes of pancreatitis.
- Postulated that in pancreas divisum, the duct of Santorini and the minor ampulla are too small to adequately drain the secretions produced by the pancreatic body and tail.
Associated Conditions
An association with adenoma of the minor papilla has been reported.[1]