Noonan syndrome ECG findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Noonan syndrome}} | {{Noonan syndrome}} | ||
{{CMG}}; {{AE}} Serge Korjian | {{CMG}}; {{AE}} [[User:Sergekorjian|Serge Korjian]], [[User:YazanDaaboul|Yazan Daaboul]] | ||
==Overview== | ==Overview== | ||
The most common findings on ECG in patients with Noonan syndrome are left-axis deviation and abnormal R/S ratio in the left precordial leads. | |||
==ECG Findings== | ==ECG Findings== | ||
Electrocardiograms in patients with Noonan syndrome often show wide QRS complexes, inverted T waves in lead III and V1-V3 | Electrocardiograms in patients with Noonan syndrome often show a combination of the following: left-axis deviation, abnormal R/S ratio in the left precordial leads, wide QRS complexes, inverted T waves in lead III and V1-V3, and giant Q waves.<ref name="pmid6884370">{{cite journal| author=Sanchez-Cascos A| title=The Noonan syndrome. | journal=Eur Heart J | year= 1983 | volume= 4 | issue= 4 | pages= 223-9 | pmid=6884370 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6884370 }} </ref><ref name="pmid18270737">{{cite journal| author=Raaijmakers R, Noordam C, Noonan JA, Croonen EA, van der Burgt CJ, Draaisma JM| title=Are ECG abnormalities in Noonan syndrome characteristic for the syndrome? | journal=Eur J Pediatr | year= 2008 | volume= 167 | issue= 12 | pages= 1363-7 | pmid=18270737 | doi=10.1007/s00431-008-0670-9 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18270737 }} </ref> ECG findings are often not related to detectable structural abnormalities of heart and chest wall and may be present independently of established heart disease.<ref name="pmid23312968">{{cite journal| author=Roberts AE, Allanson JE, Tartaglia M, Gelb BD| title=Noonan syndrome. | journal=Lancet | year= 2013 |volume= 381 | issue= 9863 | pages= 333-42 | pmid=23312968 | doi=10.1016/S0140-6736(12)61023-X | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23312968 }} </ref> Other findings may include sinus bradycardia, RBBB, and other signs of right and left ventricular overload depending on the phenotypic presentation of the disease.<ref name="pmid11080752">{{cite journal| author=Bertola DR, Kim CA, Sugayama SM, Albano LM, Wagenführ J, Moysés RL et al.| title=Cardiac findings in 31 patients with Noonan's syndrome. | journal=Arq Bras Cardiol | year= 2000 | volume= 75 | issue= 5 | pages= 409-12 | pmid=11080752 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11080752 }} </ref> | ||
==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
{{Phakomatoses and other congenital malformations not elsewhere classified}} | {{Phakomatoses and other congenital malformations not elsewhere classified}} |
Latest revision as of 02:18, 15 November 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Serge Korjian, Yazan Daaboul
Overview
The most common findings on ECG in patients with Noonan syndrome are left-axis deviation and abnormal R/S ratio in the left precordial leads.
ECG Findings
Electrocardiograms in patients with Noonan syndrome often show a combination of the following: left-axis deviation, abnormal R/S ratio in the left precordial leads, wide QRS complexes, inverted T waves in lead III and V1-V3, and giant Q waves.[1][2] ECG findings are often not related to detectable structural abnormalities of heart and chest wall and may be present independently of established heart disease.[3] Other findings may include sinus bradycardia, RBBB, and other signs of right and left ventricular overload depending on the phenotypic presentation of the disease.[4]
References
- ↑ Sanchez-Cascos A (1983). "The Noonan syndrome". Eur Heart J. 4 (4): 223–9. PMID 6884370.
- ↑ Raaijmakers R, Noordam C, Noonan JA, Croonen EA, van der Burgt CJ, Draaisma JM (2008). "Are ECG abnormalities in Noonan syndrome characteristic for the syndrome?". Eur J Pediatr. 167 (12): 1363–7. doi:10.1007/s00431-008-0670-9. PMID 18270737.
- ↑ Roberts AE, Allanson JE, Tartaglia M, Gelb BD (2013). "Noonan syndrome". Lancet. 381 (9863): 333–42. doi:10.1016/S0140-6736(12)61023-X. PMID 23312968.
- ↑ Bertola DR, Kim CA, Sugayama SM, Albano LM, Wagenführ J, Moysés RL; et al. (2000). "Cardiac findings in 31 patients with Noonan's syndrome". Arq Bras Cardiol. 75 (5): 409–12. PMID 11080752.
Template:Phakomatoses and other congenital malformations not elsewhere classified