Nafcillin sodium description: Difference between revisions
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{{Nafcillin sodium}} | {{Nafcillin sodium}} | ||
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==Description== | ==Description== | ||
Nafcillin for injection, USP is a semisynthetic penicillin derived from the penicillin nucleus, 6-aminopenicillanic acid. The chemical name of nafcillin sodium is Monosodium (2S,5R,6R)-6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate monohydrate. It is resistant to inactivation by the enzyme penicillinase (beta-lactamase). The structural formula of nafcillin sodium is as follows:<ref>{{Cite web | last = | first = | title = NAFCILLIN (NAFCILLIN SODIUM) INJECTION, POWDER, FOR SOLUTION [AUROMEDICS PHARMA LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=8ec288e6-4d7f-4fea-a5ab-f9f337ebaa86 | publisher = | date = | accessdate = }}</ref> | Nafcillin for injection, USP is a semisynthetic penicillin derived from the penicillin nucleus, 6-aminopenicillanic acid. The chemical name of nafcillin sodium is Monosodium (2S,5R,6R)-6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate monohydrate. It is resistant to inactivation by the enzyme penicillinase (beta-lactamase). The structural formula of nafcillin sodium is as follows:<ref>{{Cite web | last = | first = | title = NAFCILLIN (NAFCILLIN SODIUM) INJECTION, POWDER, FOR SOLUTION [AUROMEDICS PHARMA LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=8ec288e6-4d7f-4fea-a5ab-f9f337ebaa86 | publisher = | date = | accessdate = }}</ref> | ||
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Nafcillin for injection, USP for the intravenous route of administration, contains nafcillin sodium as a sterile white to yellowish-white powder for reconstitution. The pH of the reconstituted solution is 6.0 to 8.5. Nafcillin for injection, USP contains nafcillin sodium as the monohydrate equivalent to 10 grams of nafcillin per Pharmacy Bulk Package and is buffered with 40 mg sodium citrate per gram. The sodium content is 65.78 mg [2.9 mEq] per gram. | |||
A Pharmacy Bulk Package is a container of sterile dosage form which contains many single doses. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion. FURTHER DILUTION IS REQUIRED AFTER RECONSTITUTION (see DOSAGE AND ADMINISTRATION, and DIRECTIONS FOR PROPER USE OF PHARMACY BULK PACKAGE) | |||
==References== | ==References== | ||
Latest revision as of 00:48, 24 December 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]
Description
Nafcillin for injection, USP is a semisynthetic penicillin derived from the penicillin nucleus, 6-aminopenicillanic acid. The chemical name of nafcillin sodium is Monosodium (2S,5R,6R)-6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate monohydrate. It is resistant to inactivation by the enzyme penicillinase (beta-lactamase). The structural formula of nafcillin sodium is as follows:[1]
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Nafcillin for injection, USP for the intravenous route of administration, contains nafcillin sodium as a sterile white to yellowish-white powder for reconstitution. The pH of the reconstituted solution is 6.0 to 8.5. Nafcillin for injection, USP contains nafcillin sodium as the monohydrate equivalent to 10 grams of nafcillin per Pharmacy Bulk Package and is buffered with 40 mg sodium citrate per gram. The sodium content is 65.78 mg [2.9 mEq] per gram.
A Pharmacy Bulk Package is a container of sterile dosage form which contains many single doses. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion. FURTHER DILUTION IS REQUIRED AFTER RECONSTITUTION (see DOSAGE AND ADMINISTRATION, and DIRECTIONS FOR PROPER USE OF PHARMACY BULK PACKAGE)
References
Adapted from the FDA Package Insert.