Ethionamide description: Difference between revisions
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==Description== | ==Description== | ||
Trecator® (ethionamide tablets, USP) is used in the treatment of tuberculosis. The chemical name for ethionamide is 2-ethylthioisonicotinamide with the following structural formula: | Trecator® (ethionamide tablets, USP) is used in the treatment of [[tuberculosis]]. The chemical name for ethionamide is 2-ethylthioisonicotinamide with the following structural formula: | ||
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Ethionamide is a yellow crystalline, nonhygroscopic compound with a faint to moderate sulfide odor and a melting point of 162°C. It is practically insoluble in water and ether, but soluble in methanol and ethanol. It has a partition coefficient (octanol/water) Log P value of 0.3699. Trecator tablets contain 250 mg of ethionamide. The inactive ingredients present are croscarmellose sodium, FD&C Yellow #6, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, silicon dioxide, talc, and titanium dioxide.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = TRECATOR (ETHIONAMIDE) TABLET, FILM COATED [WYETH PHARMACEUTICALS COMPANY, A SUBSIDIARY OF PFIZER INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=04a413fe-95f4-47a7-42ac-283a9e78297d | publisher = | date = | accessdate }}</ref> | |||
Ethionamide is a yellow crystalline, nonhygroscopic compound with a faint to moderate sulfide odor and a melting point of 162°C. It is practically insoluble in water and ether, but soluble in methanol and ethanol. It has a partition coefficient (octanol/water) Log P value of 0.3699. Trecator tablets contain 250 mg of ethionamide. The inactive ingredients present are croscarmellose sodium, FD&C Yellow #6, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, silicon dioxide, talc, and titanium dioxide. | |||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = TRECATOR (ETHIONAMIDE) TABLET, FILM COATED [WYETH PHARMACEUTICALS COMPANY, A SUBSIDIARY OF PFIZER INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=04a413fe-95f4-47a7-42ac-283a9e78297d | publisher = | date = | accessdate }}</ref> | |||
==References== | ==References== | ||
Latest revision as of 02:55, 31 December 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]
Description
Trecator® (ethionamide tablets, USP) is used in the treatment of tuberculosis. The chemical name for ethionamide is 2-ethylthioisonicotinamide with the following structural formula:
 |
Ethionamide is a yellow crystalline, nonhygroscopic compound with a faint to moderate sulfide odor and a melting point of 162°C. It is practically insoluble in water and ether, but soluble in methanol and ethanol. It has a partition coefficient (octanol/water) Log P value of 0.3699. Trecator tablets contain 250 mg of ethionamide. The inactive ingredients present are croscarmellose sodium, FD&C Yellow #6, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, silicon dioxide, talc, and titanium dioxide.[1]
References
- ↑ "TRECATOR (ETHIONAMIDE) TABLET, FILM COATED [WYETH PHARMACEUTICALS COMPANY, A SUBSIDIARY OF PFIZER INC.]". Text " accessdate " ignored (help)
Adapted from the FDA Package Insert.