Penicillin G procaine drug interactions: Difference between revisions
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==Drug Interactions== | ==Drug Interactions== | ||
Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided. | [[Tetracycline]], a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided. | ||
Concurrent administration of | Concurrent administration of [[penicillins]] and [[probenecid]] increases and prolongs serum penicillin levels by decreasing the apparent volume of distribution and slowing the rate of excretion by competitively inhibiting renal tubular secretion of penicillin.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = BICILLIN CR (PENICILLIN G BENZATHINE AND PENICILLIN G PROCAINE) INJECTION, SUSPENSION [PFIZER LABORATORIES DIV PFIZER INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b5640fc6-76d8-428d-80e6-760d769af8bb | publisher = | date = | accessdate}}</ref> | ||
==References== | ==References== | ||
Latest revision as of 20:47, 3 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]
Drug Interactions
Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided.
Concurrent administration of penicillins and probenecid increases and prolongs serum penicillin levels by decreasing the apparent volume of distribution and slowing the rate of excretion by competitively inhibiting renal tubular secretion of penicillin.[1]
References
Adapted from the FDA Package Insert.