Atovaquone overdosage: Difference between revisions
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==Overdosage== | |||
There is no known antidote for atovaquone, and it is currently unknown if atovaquone is dialyzable. The median lethal dose is higher than the maximum oral dose tested in mice and rats (1,825 mg/kg/day). Overdoses up to 31,500 mg of atovaquone have been reported. In 1 such patient who also took an unspecified dose of dapsone, methemoglobinemia occurred. Rash has also been reported after overdose.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = MEPRON (ATOVAQUONE) SUSPENSION [GLAXOSMITHKLINE LLC] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b426b6bf-f07e-4580-97ae-dfca1ddf5b8f | publisher = | date = | accessdate = }}</ref> | |||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = MEPRON (ATOVAQUONE) SUSPENSION [GLAXOSMITHKLINE LLC] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b426b6bf-f07e-4580-97ae-dfca1ddf5b8f | publisher = | date = | accessdate = }}</ref> | |||
==References== | ==References== | ||
Latest revision as of 01:27, 7 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overdosage
There is no known antidote for atovaquone, and it is currently unknown if atovaquone is dialyzable. The median lethal dose is higher than the maximum oral dose tested in mice and rats (1,825 mg/kg/day). Overdoses up to 31,500 mg of atovaquone have been reported. In 1 such patient who also took an unspecified dose of dapsone, methemoglobinemia occurred. Rash has also been reported after overdose.[1]
References
Adapted from the FDA Package Insert.