Neomycin drug interactions: Difference between revisions
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Caution should be taken in concurrent or serial use of other neurotoxic and/or nephrotoxic drugs because of possible enhancement of the [[nephrotoxicity]] and/or [[ototoxicity]] of neomycin (see boxed WARNINGS ). | Caution should be taken in concurrent or serial use of other neurotoxic and/or nephrotoxic drugs because of possible enhancement of the [[nephrotoxicity]] and/or [[ototoxicity]] of neomycin (see boxed WARNINGS ). | ||
Caution should also be taken in concurrent or serial use of other aminoglycosides and | Caution should also be taken in concurrent or serial use of other aminoglycosides and [[polymyxin]]s because they may enhance neomycin's [[nephrotoxicity]] and/or [[ototoxicity]] and potentiate neomycin's neuromuscular blocking effects. | ||
Oral neomycin inhibits the gastrointestinal absorption of [[penicillin V]], oral [[vitamin B12]], [[methotrexate]] and 5-[[fluorouracil]]. The gastrointestinal absorption of [[digoxin]] also appears to be inhibited. Therefore, digoxin serum levels should be monitored. | Oral neomycin inhibits the gastrointestinal absorption of [[penicillin V]], oral [[vitamin B12]], [[methotrexate]] and 5-[[fluorouracil]]. The gastrointestinal absorption of [[digoxin]] also appears to be inhibited. Therefore, digoxin serum levels should be monitored. | ||
Latest revision as of 17:26, 7 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Drug Interactions
Caution should be taken in concurrent or serial use of other neurotoxic and/or nephrotoxic drugs because of possible enhancement of the nephrotoxicity and/or ototoxicity of neomycin (see boxed WARNINGS ).
Caution should also be taken in concurrent or serial use of other aminoglycosides and polymyxins because they may enhance neomycin's nephrotoxicity and/or ototoxicity and potentiate neomycin's neuromuscular blocking effects.
Oral neomycin inhibits the gastrointestinal absorption of penicillin V, oral vitamin B12, methotrexate and 5-fluorouracil. The gastrointestinal absorption of digoxin also appears to be inhibited. Therefore, digoxin serum levels should be monitored.
Oral neomycin may enhance the effect of coumarin in anticoagulants by decreasing vitamin K availability.[1]
References
Adapted from the FDA Package Insert.